Pat Preisig, PhD
Professor of Medicine (Nephrology) and of Cellular And Molecular PhysiologyDownloadHi-Res Photo
Cards
Appointments
Nephrology
Primary
Cellular & Molecular Physiology
Secondary
Contact Info
About
Titles
Professor of Medicine (Nephrology) and of Cellular And Molecular Physiology
Appointments
Nephrology
ProfessorPrimaryCellular & Molecular Physiology
ProfessorSecondary
Other Departments & Organizations
- Cellular & Molecular Physiology
- Embryonic Stem Cell Research Oversight
- Internal Medicine
- Nephrology
- Yale Ventures
Education & Training
- PhD
- University of California at San Francisco, Physiology (1983)
- MS
- University of California at San Francisco, Nephrology Nursing (1979)
- BSN
- California State University, Nursing (1975)
Research
Overview
Medical Research Interests
Kidney; Kidney Tubules, Proximal; Nephrology; Physiology
Research at a Glance
Yale Co-Authors
Frequent collaborators of Pat Preisig's published research.
Publications Timeline
A big-picture view of Pat Preisig's research output by year.
Research Interests
Research topics Pat Preisig is interested in exploring.
Robert Alpern, MD
Xuefei Tian, MD
77Publications
3,144Citations
Kidney
Kidney Tubules, Proximal
Publications
2018
Acid Stimulation of the Citrate Transporter NaDC-1 Requires Pyk2 and ERK1/2 Signaling Pathways
Zacchia M, Tian X, Zona E, Alpern RJ, Preisig PA. Acid Stimulation of the Citrate Transporter NaDC-1 Requires Pyk2 and ERK1/2 Signaling Pathways. Journal Of The American Society Of Nephrology 2018, 29: 1720-1730. PMID: 29678998, PMCID: PMC6054333, DOI: 10.1681/asn.2017121268.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAcidsAmmonium ChlorideAnimalsCells, CulturedCitric AcidCSK Tyrosine-Protein KinaseDicarboxylic Acid TransportersEndothelin-1Epithelial CellsFocal Adhesion Kinase 2Kidney Tubules, ProximalMAP Kinase Signaling SystemMiceMice, KnockoutMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3OpossumsOrganic Anion Transporters, Sodium-DependentPhosphorylationProto-Oncogene Proteins c-rafReceptor, Endothelin BRibosomal Protein S6 Kinases, 90-kDasrc-Family KinasesTransfectionConceptsET-1/ETEndothelin-1Proximal tubulesCultured opossum kidney cellsAcid stimulationInhibition of Pyk2ET-1 stimulationRenal proximal tubulesNaDC-1Opossum kidney cellsCl loadingC-SrcPhosphorylation of Raf1Urine citratePyk2 knockdownEnd pointAcid loadApical NaERK1/2 pathwayStimulationMiceKidney cellsKidneyPyk2ERK1/2
2017
Tough decisions about protocol review
Preisig PA, Silverman J, Brown P, Petervary N. Tough decisions about protocol review. Lab Animal 2017, 46: 290-294. PMID: 28644450, DOI: 10.1038/laban.1300.Commentaries, Editorials and LettersThe role of the IACUC in ensuring research reproducibility
Silverman J, Macy J, Preisig PA. The role of the IACUC in ensuring research reproducibility. Lab Animal 2017, 46: 129-135. PMID: 28328872, DOI: 10.1038/laban.1213.Commentaries, Editorials and LettersCitationsAltmetric
2015
Response to Protocol Review Scenario: One wrong, one right
Preisig PA, Macy JD. Response to Protocol Review Scenario: One wrong, one right. Lab Animal 2015, 44: 87-88. PMID: 25693102, DOI: 10.1038/laban.705.Commentaries, Editorials and Letters
2014
Response to Protocol Review Scenario: Not so fast.
Preisig PA, Fusco KA. Response to Protocol Review Scenario: Not so fast. Lab Animal 2014, 43: 81. PMID: 24552907, DOI: 10.1038/laban.478.Commentaries, Editorials and Letters
2013
Chapter 55 Cellular Mechanisms of Renal Tubular Acidification
Hamm L, Alpern R, Preisig P. Chapter 55 Cellular Mechanisms of Renal Tubular Acidification. 2013, 1917-1978. DOI: 10.1016/b978-0-12-381462-3.00055-0.ChaptersCitations
2011
Drosophila: a fruitful model for calcium oxalate nephrolithiasis?
Knauf F, Preisig PA. Drosophila: a fruitful model for calcium oxalate nephrolithiasis? Kidney International 2011, 80: 327-329. PMID: 21799502, DOI: 10.1038/ki.2011.166.Peer-Reviewed Original ResearchCitations
2010
Acid regulation of NaDC-1 requires a functional endothelin B receptor
Liu L, Zacchia M, Tian X, Wan L, Sakamoto A, Yanagisawa M, Alpern RJ, Preisig PA. Acid regulation of NaDC-1 requires a functional endothelin B receptor. Kidney International 2010, 78: 895-904. PMID: 20703215, DOI: 10.1038/ki.2010.264.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsMeSH KeywordsAcidosisAnimalsBiological TransportCell LineDicarboxylic Acid TransportersDisease Models, AnimalEndothelin B Receptor AntagonistsEndothelin-1Hydrogen-Ion ConcentrationKidneyMiceMice, KnockoutMicrovilliOligopeptidesOpossumsOrganic Anion Transporters, Sodium-DependentPiperidinesProtein Structure, TertiaryReceptor, Endothelin AReceptor, Endothelin BRecombinant Fusion ProteinsSignal TransductionSymportersTime FactorsTransfectionConceptsEndothelin-1Endothelin-B receptor antagonistFunctional endothelin B receptorsStimulatory effectAcid-stimulatory effectET-1 effectsB receptor antagonistNHE3 activityEndothelin B receptorWild-type miceET-1 stimulationMajor physiological stimulusNaDC-1Acid ingestionReceptor antagonistCitrate reabsorptionReceptor expressionCitrate excretionOpossum kidneyAcid loadB receptorAcid feedingPhysiological stimuliStimulationMiceLow urinary citrate: an overview.
Zacchia M, Preisig P. Low urinary citrate: an overview. Journal Of Nephrology 2010, 23 Suppl 16: s49-56. PMID: 21170889.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsUrinary citrate excretionCitrate excretionStone formationCalcium stone formationProximal tubule cellsAcid-base statusKidney stone formationRisk factorsFiltered loadImportant physiological determinantGlomerular filtrateTubule cellsAcid loadExcretionAlkaline loadCitrate levelsHypocitraturiaMetabolic processesMitochondrial metabolic processesPhysiological determinantsMetabolismMitochondrial metabolismCitrate metabolismNaDC1
2009
Biochemical and histological assessment of Alkali therapy during high animal protein intake in the rat
Zerwekh JE, Zou L, Pak CY, Moe OW, Preisig PA. Biochemical and histological assessment of Alkali therapy during high animal protein intake in the rat. Bone 2009, 45: 1004-1009. PMID: 19651255, PMCID: PMC2753741, DOI: 10.1016/j.bone.2009.07.077.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsHigh animal protein intakeAnimal protein intakeAlkali therapyBone histomorphometryBone turnoverProtein intakeAcid loadChronic acid loadMajor skeletal effectCancellous bone volumeHigh casein dietNegative calcium balanceDynamic bone histomorphometryLow urinary pHBone formation rateDietary animal protein intakeStatic bone histomorphometryNet acid excretionLow caseinSubstantial acid loadOsteoclastic surfaceWesternized dietUrinary pHUrine biochemistryBone resorption
Academic Achievements & Community Involvement
Activities
activity Yale University
07/01/2007 - PresentCommitteesCommittee MemberDetailsCommittee memberactivity Yale University
07/01/2014 - PresentCommitteesCommittee MemberDetailsCommittee member
News
News
- October 15, 2024
Meet Lonnette Diggs, Research Associate II, Nephrology
- October 15, 2024
Core Profiles Kidney’s Role in Homeostasis
- October 31, 2018
Ten years of music from Yale Medical Symphony Orchestra
- October 17, 2018Source: Yale Medicine Magazine
Ten years of music from Yale Medical Symphony Orchestra