Voluntary Faculty
Voluntary faculty are typically clinicians or others who are employed outside of the School but make significant contributions to department programs at the medical center or at affiliate institutions.
Voluntary rank detailsPadmini Manrai, MD
Clinical InstructorDownloadHi-Res Photo
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Biography
Dr. Padmini Manrai is currently the clinical fellow of Gynecologic Pathology. She obtained her medical degree in 2017 from Thomas Jefferson University. She then completed a residency in Anatomic and Clinical Pathology (2021) and fellowship in Cytopathology (2022) at Yale New Haven Hospital. Her clinical interests focus on women's health with a special interest in cervical cancer and development of evidence-based frameworks for diagnosis, reporting, and management of disease as well as medical education. She is an instructor in the Across the Lifespan master course for medical students at Yale School of Medicine focusing on gynecologic and breast pathology.
Last Updated on April 13, 2025.
Education & Training
- Resident
- Yale New Haven Health (2021)
- MD
- Jefferson Medical College (2017)
- BA
- University of Delaware (2007)
Research
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Overview
Medical Research Interests
Women's Health
ORCID
0000-0003-3401-6820
Research at a Glance
Yale Co-Authors
Frequent collaborators of Padmini Manrai's published research.
Publications Timeline
A big-picture view of Padmini Manrai's research output by year.
Natalia Buza, MD
Pei Hui, PhD, MD
Alessandro Santin, MD
Alexa Siddon, MD
Christopher Tormey, MD
Darin Dolezal, MD, PhD
10Publications
104Citations
Publications
Featured Publications
Surgical management of inguinal endometriosis: Case report and surgical video
Beroukhim G, Esencan E, Manrai P, Azodi M, K Cho Y. Surgical management of inguinal endometriosis: Case report and surgical video. Journal Of Case Reports And Images In Obstetrics And Gynecology 2023, 9: 11-16. DOI: 10.5348/100136z08gb2023cr.Peer-Reviewed Original ResearchCitationsConceptsInguinal endometriosisInguinal massDiagnostic laparoscopySurgical managementCase reportPainful right inguinal massExtra-pelvic endometriosisRight inguinal massAbsence of symptomsInternal inguinal ringStep surgical approachNulligravid womenExcisional surgeryRound ligamentSurgical approachEndometriosisTissue biopsiesInguinal ringRare typeMultidisciplinary teamLaparoscopyWorkupSurgical videosAccompanying videoReportLIMK2 promotes the metastatic progression of triple-negative breast cancer by activating SRPK1
Malvi P, Janostiak R, Chava S, Manrai P, Yoon E, Singh K, Harigopal M, Gupta R, Wajapeyee N. LIMK2 promotes the metastatic progression of triple-negative breast cancer by activating SRPK1. Oncogenesis 2020, 9: 77. PMID: 32859889, PMCID: PMC7455732, DOI: 10.1038/s41389-020-00263-1.Peer-Reviewed Original ResearchCitationsAltmetricConceptsTriple-negative breast cancerLIM domain kinase 2Metastatic progressionPharmacological inhibitionBreast cancerTNBC cellsMetastatic attributesMetastatic breast cancer subtypesSerine/arginine protein kinasesPrimary tumor growthBreast cancer subtypesKinase 2Serine/threonine kinaseActin filament dynamicsStable isotope labelingShort hairpin RNASystemic therapyProtein kinase 1Therapeutic optionsHER2 expressionLarge-scale phosphoproteomic analysisTNBC metastasisTumor growthCancer subtypesSR familyCorrelative Assessment of p53 Immunostaining Patterns and TP53 Mutation Status by Next-Generation Sequencing in High-Grade Endometrial Carcinomas
Matsumoto N, Manrai P, Rottmann D, Wu X, Assem H, Hui P, Buza N. Correlative Assessment of p53 Immunostaining Patterns and TP53 Mutation Status by Next-Generation Sequencing in High-Grade Endometrial Carcinomas. International Journal Of Gynecological Pathology 2022, 42: 567-575. PMID: 36730675, DOI: 10.1097/pgp.0000000000000930.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsHigh-grade endometrial carcinomasEndometrial carcinomaEndometrioid endometrial carcinomaTP53 mutation statusP53 immunohistochemistrySerous componentIHC staining patternNext-generation sequencing resultsNuclear overexpressionGrade 3 endometrioid endometrial carcinomaMutation statusTP53 mutationsCytoplasmic stainingStaining patternSerous endometrial carcinomaAberrant p53 expressionMixed endometrial carcinomasClinical prognosisSurrogate markerAberrant p53 proteinTherapeutic decisionsIHC patternsTP53 alterationsTumor histotypesP53 expression
2025
Invasive Acantholytic Extramammary Paget's Disease of the Vulva With Mammary Carcinoma-Like Differentiation and MMR Loss: Report of an Unusual Case and Its Clinical Mimics
Claus J, Pearce J, Bojko A, Manrai P, Quddus M, Marketkar S. Invasive Acantholytic Extramammary Paget's Disease of the Vulva With Mammary Carcinoma-Like Differentiation and MMR Loss: Report of an Unusual Case and Its Clinical Mimics. Gynecologic Oncology Reports 2025, 63: 102007. PMID: 41561668, PMCID: PMC12813102, DOI: 10.1016/j.gore.2025.102007.Peer-Reviewed Original ResearchConceptsDuctal carcinoma in situCarcinoma in situExtramammary Paget's diseasePaget's diseaseSquamous cell carcinoma in situCell carcinoma in situBiopsy-proven carcinomaExtramammary Paget's carcinomaPositive lymph nodesInvasive ductal carcinomaLoss of MMRIn situ componentLeft vulvaRadical hemivulvectomyPostmenopausal womenRare entityDuctal carcinomaPrognostic factorsIntraepidermal acantholysisInvasive adenocarcinomaInvasive componentPaget's carcinomaClinical mimicsFemale patientsInvasive diseaseDiagnostic and management challenges in a partially infarcted borderline phyllodes tumor in an adolescent female: A case report and review of literature
Suschana E, Ines F, Manrai P, Koelliker S, Gass J, Tseng Y. Diagnostic and management challenges in a partially infarcted borderline phyllodes tumor in an adolescent female: A case report and review of literature. World Journal Of Clinical Pediatrics 2025, 14: 102741. PMID: 40881099, PMCID: PMC12304955, DOI: 10.5409/wjcp.v14.i3.102741.Peer-Reviewed Original ResearchCitationsConceptsDiagnosis of phyllodes tumorMargin re-excisionBorderline phyllodes tumorPhyllodes tumorBorderline PTRe-ExcisionSurgical excisionBreast massesFinal pathologySurgical marginsTumor enlargementTumor infarctionRecurrence rateMargin statusAdolescent patientsWork-upDiagnosis prior to surgical interventionBenign breast parenchymaPositive surgical marginsRe-excision proceduresRight breast massCore needle biopsyComplete surgical excisionPathologic follow-upPediatric breast masses
2024
Myoid Hamartoma of the Breast With HMGA2 Rearrangement and Associated In-Situ and Invasive Carcinoma: Case Report and Review of Literature
Ines F, Marketkar S, Ng S, Manrai P, Sung C, Bridge J, Singh K. Myoid Hamartoma of the Breast With HMGA2 Rearrangement and Associated In-Situ and Invasive Carcinoma: Case Report and Review of Literature. International Journal Of Surgical Pathology 2024, 33: 689-699. PMID: 39471995, DOI: 10.1177/10668969241271420.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsMyoid hamartomaInvasive carcinomaGene rearrangementsLikelihood of malignant transformationBenign breast neoplasmsBenign clinical courseFluorescence in situ hybridization analysisRare breast lesionSmooth muscle bundlesClinical courseStromal compartmentCase reportOverexpression of HMGA2Breast lesionsMalignant transformationRadiological studiesBreast neoplasmsHMGA2 rearrangementsAncillary testsProtein overexpressionHamartomaMolecular findingsStromal cellsAnechoic areasAdipose tissueTargetable ERBB2/HER2 Mutations in Gynecologic Malignancies: Clinicopathological, Immunohistochemical, and Molecular Correlations
Manrai P, McHenry A, Sun T, Santin A, Ratner E, Lin D, Elvin J, Hui P, Buza N. Targetable ERBB2/HER2 Mutations in Gynecologic Malignancies: Clinicopathological, Immunohistochemical, and Molecular Correlations. International Journal Of Gynecological Pathology 2024, 44: 144-154. PMID: 38914011, DOI: 10.1097/pgp.0000000000001050.Peer-Reviewed Original ResearchCitationsConceptsEndometrial carcinomaGynecologic malignanciesTyrosine kinase domainHER2-mutated non-small cell lung cancerTargeted anti-HER2 therapyNon-small cell lung cancerHigh-grade endometrioid adenocarcinomasFam-trastuzumab deruxtecanOvarian mucinous adenocarcinomaAnti-HER2 therapyAnti-HER2 drugsHER2 3+US Food and Drug AdministrationCell lung cancerEndometrial serous carcinomaSolid tumor typesStandard treatment recommendationsFood and Drug AdministrationFluorescence in situ hybridizationGynecological cancer typesEndometrial primaryMullerian originSerous carcinomaHER2 IHCEndometrioid adenocarcinoma
2023
Breast Carcinoma With Tubulopapillary Features Has a Distinct Immunophenotypic and Molecular Signature: A Report of Two Tumors and Literature Review
Carrasco-Tenezaca F, Moreira-Dinzey J, Manrai P, Bearse M, Burela S, Podany P, Singh K, Pareja F, Zheng J, Muscato N, Liang Y, Zhan H, Krishnamurti U, Dolezal D, Wang J, Harigopal M. Breast Carcinoma With Tubulopapillary Features Has a Distinct Immunophenotypic and Molecular Signature: A Report of Two Tumors and Literature Review. International Journal Of Surgical Pathology 2023, 32: 1037-1045. PMID: 37908113, DOI: 10.1177/10668969231209780.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsConceptsBreast carcinomaTubulopapillary featuresHuman epidermal growth factor 2 (HER2) expressionBreast cancer histologic subtypesNonmetastatic breast carcinomaTriple-negative profileHigh-grade nuclear featuresTriple-negative carcinomasHigh-grade featuresMetastatic breast carcinomaGrowth factor 2 expressionFactor 2 expressionReports of tumorsMicropapillary projectionsNeoadjuvant therapyHistologic subtypeWorse prognosisFirst tumorPoor prognosisAdditional tumorsInvasive carcinomaEstrogen receptorCarcinomaPathogenic variantsTumors
2021
Development of anti-Jk3 associated with silenced Kidd antigen expression and a novel single nucleotide variant of the JK gene
Manrai PA, Siddon AJ, Hager KM, Hendrickson JE, Keller MA, Tormey CA. Development of anti-Jk3 associated with silenced Kidd antigen expression and a novel single nucleotide variant of the JK gene. Immunohematology 2021, 37: 109-112. PMID: 34591379, DOI: 10.21307/immunohematology-2021-015.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsHigh-prevalence antigenReagent red blood cellsDirect antiglobulin testBlood samplesBlood group APatient blood samplesImmunohematology reference laboratoryRare alloantibodyRed blood cellsOncologic careAntiglobulin testGroup APolynesian descentBlood cellsNon-conservative amino acid changeSingle nucleotide variantsReference laboratoryAmino acid changesFamilial backgroundExon 8Antigen expressionExon 7Nucleotide variantsAcid changesExon 4
2009
CIB1 deficiency results in impaired thrombosis: the potential role of CIB1 in outside‐in signaling through integrin αIIbβ3
NAIK MU, NIGAM A, MANRAI P, MILLILI P, CZYMMEK K, SULLIVAN M, NAIK UP. CIB1 deficiency results in impaired thrombosis: the potential role of CIB1 in outside‐in signaling through integrin αIIbβ3. Journal Of Thrombosis And Haemostasis 2009, 7: 1906-1914. PMID: 19691476, PMCID: PMC7034629, DOI: 10.1111/j.1538-7836.2009.03581.x.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMouse tail bleeding timeTail bleeding timeGene knockout miceAbility of plateletsWestern blot analysisBleeding timeComplete occlusionCarotid arteryActivate plateletsProcess of hemostasisPhysiological hemostasisThrombosisKnockout miceThrombus formationPlatelet aggregationNull micePlasma fibrinogenPathological thrombosisGenetic ablationUnstable thrombus formationHemostasisNull plateletsPotential rolePlateletsFibrinogen binding
Academic Achievements & Community Involvement
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Activities
activity Incorporating a Flipped Classroom in Graduate Medical Education for Pathology Residents Using a Team Based Approach
03/02/2020 - PresentOral PresentationUSCAP 110th Annual MeetingDetailsLos Angeles, CA, United StatesSponsored by USCAPAbstract/SynopsisSelected to present at the annual spring meeting of Association of Pathology Chairs (PRODS) held at USCAP. Talk title: "Incorporating a Flipped Classroom in Graduate Medical Education for Pathology Residents Using a Team Based Approach".
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