Nay Nwe Nyein Chan
Associate Research ScientistCards
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Research
Publications
2025
Validation and Prospective Testing of a High-Sensitivity, Quantitative Analytic Assay for HER2 on Histopathology Slides
Chan N, Gaule P, Benanto J, Scott L, Robbins C, He M, Bates K, Khaimova R, Liebler D, Fulton R, Rimm D. Validation and Prospective Testing of a High-Sensitivity, Quantitative Analytic Assay for HER2 on Histopathology Slides. Laboratory Investigation 2025, 105: 104233. PMID: 40882816, PMCID: PMC12500179, DOI: 10.1016/j.labinv.2025.104233.Peer-Reviewed Original ResearchHuman epidermal growth factor receptor 2Selection of patientsT-DXdHER2 expressionApprovals of antibody-drug conjugatesLow-level HER2 expressionAccurate selection of patientsEpidermal growth factor receptor 2Levels of human epidermal growth factor receptor 2Antibody-drug conjugate therapyCore biopsy specimensCompanion diagnostic testsAntibody-drug conjugatesHER2 assaysBiopsy specimensConjugate therapyReceptor 2IHC assayProspective casesPathologist scoresHistopathology slidesDiagnostic testsIHCCoefficient of variation <Pathology laboratoryQuantitative assessment of HER2 expression in invasive ductal carcinoma and co-existing DCIS
Zhan H, Chan N, Khaimova R, Aung T, Gaule P, Robbins C, Rimm D. Quantitative assessment of HER2 expression in invasive ductal carcinoma and co-existing DCIS. Breast Cancer Research And Treatment 2025, 213: 273-279. PMID: 40679712, DOI: 10.1007/s10549-025-07781-9.Peer-Reviewed Original ResearchConceptsDuctal carcinoma in situIntermediate-grade ductal carcinoma in situHigh-grade ductal carcinoma in situInvasive carcinomaHER2 expressionHER2 levelsBloom Richardson histological grading systemDuctal carcinoma in situ casesGrading systemFFPE tumor specimensAssessment of HER2 expressionCarcinoma in situHER2 protein expressionInvasive ductal carcinomaNuclear grading systemHER2 expression levelsHistological grading systemNo significant statistical differenceHER2 immunohistochemical scoresHER2 biologyExpression levelsDuctal carcinomaNuclear gradeTumor specimensHistopathological gradeQuantitative Multiplex Immunofluorescence Assay for Trophoblast Cell-Surface Antigen 2 and Human Epidermal Growth Factor Receptor 2 Expression in Breast Cancer: Toward Guiding Patient Selection for Antibody-Drug Conjugate Therapies
Robbins C, He M, Chan N, Khaimova R, Bates K, Trontzas I, Scott L, Moutafi M, Coleman C, Hill S, Liebler D, Fulton R, Rimm D. Quantitative Multiplex Immunofluorescence Assay for Trophoblast Cell-Surface Antigen 2 and Human Epidermal Growth Factor Receptor 2 Expression in Breast Cancer: Toward Guiding Patient Selection for Antibody-Drug Conjugate Therapies. JCO Precision Oncology 2025, 9: e2500128. PMID: 40669019, PMCID: PMC12490811, DOI: 10.1200/po-25-00128.Peer-Reviewed Original ResearchThis study investigates a multiplex immunofluorescence assay for measuring HER2 and TROP2 in breast cancer, showing potential to guide personalized antibody-drug conjugate therapies.Pathologist-Read vs AI-Driven Assessment of Tumor-Infiltrating Lymphocytes in Melanoma
Aung T, Liu M, Su D, Shafi S, Boyaci C, Steen S, Tsiknakis N, Vidal J, Maher N, Micevic G, Tan S, Vesely M, Nourmohammadi S, Bai Y, Djureinovic D, Wong P, Bates K, Chan N, Gavirelatou N, He M, Burela S, Barna R, Bosic M, Bräutigam K, Illabochaca I, Chenhao Z, Gama J, Kreis B, Mohacsi R, Pillar N, Pinto J, Poulios C, Toli M, Tzoras E, Bracero Y, Bosisio F, Cserni G, Dema A, Fortarezza F, Gonzalez M, Gullo I, Gutiérrez F, Hacihasanoglu E, Jovic V, Lazar B, Olinca M, Neppl C, Oliveira R, Pezzuto F, Pinto D, Plotar V, Pop O, Rau T, Skok K, Sun W, Serbes E, Solass W, Stanowska O, Szasz M, Szymonski K, Thimm F, Vignati D, Vigdorovits A, Prieto V, Sinnberg T, Wilmott J, Cowper S, Warrell J, Saenger Y, Hartman J, Plummer J, Osman I, Rimm D, Acs B. Pathologist-Read vs AI-Driven Assessment of Tumor-Infiltrating Lymphocytes in Melanoma. JAMA Network Open 2025, 8: e2518906. PMID: 40608341, PMCID: PMC12232186, DOI: 10.1001/jamanetworkopen.2025.18906.Peer-Reviewed Original ResearchConceptsTumor-infiltrating lymphocytesIntraclass correlation coefficientHazard ratioPrognostic studyTIL scorePrognostic valuePrognostic associationRetrospective cohortTumor-infiltrating lymphocyte quantificationAssessment of tumor-infiltrating lymphocytesRetrospective cohort of patientsTumour-infiltrating lymphocyte assessmentMultivariate Cox regression analysisEosin-stained slidesCohort of patientsWhole tissue sectionsCox regression analysisTissue sectionsMelanoma tissue sectionsImmunotherapy outcomesMelanoma managementClinicopathological variablesRetrospective natureTest cohortInterobserver variabilityQuantitative Protein Expression of Antibody-Drug Conjugate Targets in EGFR Mutated and Wild-type Non-Small Cell Lung Cancer.
Trontzas I, He M, Wurtz A, Robbins C, Robinson N, Bates K, Liu M, Aung T, Scott L, Chan N, Burela S, Schillo J, Liebler D, Hill S, Morrison R, Vathiotis I, Syrigos K, Goldberg S, Politi K, Rimm D. Quantitative Protein Expression of Antibody-Drug Conjugate Targets in EGFR Mutated and Wild-type Non-Small Cell Lung Cancer. Clinical Cancer Research 2025, 31: 2767-2776. PMID: 40047548, PMCID: PMC12213210, DOI: 10.1158/1078-0432.ccr-24-3347.Peer-Reviewed Original ResearchNon-small cell lung cancerAntibody-drug conjugatesAntibody-drug conjugate targetsEGFR mutationsCell lung cancerEGFR expressionQuantitative immunofluorescenceWild-type non-small cell lung cancerLung cancerAssociated with EGFR mutationsAssociated with EGFR expressionTissue microarray cohortAssociation of HER2Management of patientsAssay limitProportion of casesMutation statusTROP2 expressionMicroarray cohortEGFRQuantitative protein expressionTreatment sequencePatientsCell linesWild-type270 Pathological Response to Herceptin-containing Neoadjuvant Therapy in HER2 IHC2+/ISH+ and IHC3+ Early-Stage Breast Cancers
Zhan H, Chan N, Rimm D. 270 Pathological Response to Herceptin-containing Neoadjuvant Therapy in HER2 IHC2+/ISH+ and IHC3+ Early-Stage Breast Cancers. Laboratory Investigation 2025, 105: 102494. DOI: 10.1016/j.labinv.2024.102494.Peer-Reviewed Original Research127 Analytical Validation and Prospective Study of a High-Sensitivity HER2 (HS-HER2) Quantitative Immunofluorescence Assay for Enhanced Stratification of HER2-Low Breast Cancer Patients
Chan N, Gaule P, Benanto J, Robbins C, Scott L, Hill S, Morrison R, Liebler D, Fulton R, Rimm D. 127 Analytical Validation and Prospective Study of a High-Sensitivity HER2 (HS-HER2) Quantitative Immunofluorescence Assay for Enhanced Stratification of HER2-Low Breast Cancer Patients. Laboratory Investigation 2025, 105: 102351. DOI: 10.1016/j.labinv.2024.102351.Peer-Reviewed Original Research119 Reading vs Measuring: Comparison of Pathologist-Based Scores to Analytic Measurements
Bates K, Fernandez A, Martinez-Morilla S, Chan N, Benanto J, Reisenbichler E, Rimm D. 119 Reading vs Measuring: Comparison of Pathologist-Based Scores to Analytic Measurements. Laboratory Investigation 2025, 105: 102343. DOI: 10.1016/j.labinv.2024.102343.Peer-Reviewed Original Research
2024
394P Quantitative standardized high sensitivity (HS)-HER2 testing predicts outcomes with trastuzumab deruxtecan (T-DXd) for metastatic breast cancer (MBC)
Tarantino P, Kim S, Chan N, Hughes M, Smith K, D’Amico O, Kusmick R, Pereslete A, Alder L, Anders C, Morganti S, Garrido-Castro A, Lorusso P, Lustberg M, Sammons S, Lin N, Li T, Tayob N, Rimm D, Tolaney S. 394P Quantitative standardized high sensitivity (HS)-HER2 testing predicts outcomes with trastuzumab deruxtecan (T-DXd) for metastatic breast cancer (MBC). Annals Of Oncology 2024, 35: s384-s385. DOI: 10.1016/j.annonc.2024.08.342.Peer-Reviewed Original ResearchQuantitative Measurement of HER2 Expression in Non–Small Cell Lung Cancer With a High-Sensitivity Assay
Liu M, Vathiotis I, Robbins C, Chan N, Moutafi M, Burela S, Xirou V, Schalper K, Herbst R, Syrigos K, Rimm D. Quantitative Measurement of HER2 Expression in Non–Small Cell Lung Cancer With a High-Sensitivity Assay. Modern Pathology 2024, 37: 100556. PMID: 38964502, PMCID: PMC11416319, DOI: 10.1016/j.modpat.2024.100556.Peer-Reviewed Original ResearchNon-small cell lung cancerCases of non-small cell lung cancerNon-small cell lung cancer casesT-DXdCell lung cancerHER2 expressionBreast cancerRare case of non-small cell lung cancerQuantitative immunofluorescenceAntibody-drug conjugate trastuzumab deruxtecanLung cancerHER2 antibody-drug conjugatesNon-small cell lung cancer patientsDetecting HER2 expressionHER2-Targeted TherapyMetastatic breast cancerHER2 protein expressionBreast cancer casesHER2 protein levelsAntibody-drug conjugatesProportion of casesTrastuzumab deruxtecanNSCLC casesFrequency of casesImmunohistochemistry score
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Yale School of Medicine
Quantitative Diagnostics in Anatomic Pathology (QDAP) Laboratory , 15 York Street, LMP-B101
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Quantitative Diagnostics in Anatomic Pathology (QDAP) Laboratory
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Laboratory for Medicine and Pediatrics (LMP)
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New Haven, CT 06510