Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsMiriam Treggiari, MD, PhD, MPH
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About
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Titles
Professor Adjunct
Vice Chair of Clinical Research, Anesthesiology
Biography
Dr. Miriam Treggiari is Professor and Vice Chair of Clinical Research in the Department of Anesthesiology at the Yale School of Medicine. Before joining Yale, she was Endowed Professor and Vice Chair for Research at the Oregon Health and Science University. She is an internationally recognized leader in the area of clinical and outcomes research in the perioperative setting with special emphasis in critically ill and neurocritical care patients.
Dr. Treggiari received her medical training in Italy and Switzerland. Following her anesthesiology residency, she completed a fellowship in Critical Care Medicine at the Geneva University Hospital, Switzerland. She earned an MPH in Epidemiology at the University of Washington, School of Public Health and Community Medicine. In 2007, she completed a PhD in Epidemiology at the University of Washington.
Last Updated on April 07, 2025.
Appointments
Education & Training
- PhD
- University of Washington, Epidemiology (2007)
- MPH
- University of Washington, Epidemiology (2002)
- Fellow
- Geneva University Hospitals (1998)
- Resident
- Geneva University Hospitals (1997)
- Intern
- Civico Hospital (1993)
- MD
- University of Pavia (1990)
Research
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Overview
Medical Research Interests
Anesthesiology; Critical Care; Epidemiology; Perioperative Care
ORCID
0000-0003-4639-3682
Research at a Glance
Yale Co-Authors
Frequent collaborators of Miriam Treggiari's published research.
Publications Timeline
A big-picture view of Miriam Treggiari's research output by year.
Research Interests
Research topics Miriam Treggiari is interested in exploring.
Emily Sharp, PhD, ABPP
Jinlei Li, MD, PhD
Amit Bardia, MD
Christopher Tormey, MD
Clark Fisher, MD, PhD
Elaine Fajardo, MD
144Publications
5,454Citations
Critical Care
Perioperative Care
Anesthesiology
Publications
2025
Hospital and long-term outcomes for subglottic suction and polyurethane cuff versus standard endotracheal tubes in emergency intubation (PreVent 2): a randomised controlled phase 2 trial
Treggiari M, Sharp E, Ohnuma T, Fajardo E, Aydin A, Akhtar S, Kampp M, Hashemaghaie M, Potnis A, Gugel T, Simon J, Curry L, Adams K, Darji B, Sureshanand S, Hintz R, Lorzano S, Johnson C, Yanez N. Hospital and long-term outcomes for subglottic suction and polyurethane cuff versus standard endotracheal tubes in emergency intubation (PreVent 2): a randomised controlled phase 2 trial. The Lancet Respiratory Medicine 2025 PMID: 41319662, DOI: 10.1016/s2213-2600(25)00294-2.Peer-Reviewed Original ResearchCitationsAltmetricConceptsInfection-related ventilator-associated complicationsQuality of lifeVentilator-associated pneumoniaControlled phase 2 trialPhase 2 trialSubglottic suctioningEndotracheal tubeCognitive functionNational InstituteEmergency intubationLaryngeal injuryUsual careFollow-upLong-term outcome differencesEmergency departmentFollow-up visitBlood InstituteSubglottic drainageVentilator-associated complicationsEndotracheal tube groupLong-term outcomesAcute respiratory distressLong-term safetyPolyurethane-cuffed endotracheal tubePolyurethane cuffEarly Blood Pressure Targets in Acute Spinal Cord Injury
Sajdeya R, Yanez N, Kampp M, Goodman M, Zonies D, Togioka B, Nunn A, Winfield R, Martin N, Kohli A, Huynh T, Okonkwo D, Poblete R, Gilmore E, Chesnut R, Bunnell A, Ohnuma T, Hashemaghaie M, Treggiari M. Early Blood Pressure Targets in Acute Spinal Cord Injury. JAMA Network Open 2025, 8: e2525364. PMID: 40965887, PMCID: PMC12447234, DOI: 10.1001/jamanetworkopen.2025.25364.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsAcute spinal cord injurySpinal cord injuryRandomized clinical trialsConventional blood pressureBlood pressureCord injuryNeurological resuscitationConventional groupEarly blood pressure managementAmerican Spinal Injury Association Impairment Scale scoreSequential Organ Failure Assessment scoreEnd pointsOrgan Failure Assessment scoreClinical trials of patientsRandomized clinical trial of patientsBaseline to 6 monthsMotor scoresPrimary end pointMulticenter Randomized Clinical TrialSafety end pointTrial of patientsMechanical ventilatory supportAugmented blood pressureBlood pressure targetsIntensive care unit dischargeAnesthesiology Clinical Trial Networks in the United States: A Report From the Anesthesia Research Council
Hua M, BillingsIV F, Aziz M, Dutton R, Kheterpal S, Legrand M, Leslie K, Mathew J, McCann M, Subramaniam B, Treggiari M, Wijeysundera D, Gropper M. Anesthesiology Clinical Trial Networks in the United States: A Report From the Anesthesia Research Council. Anesthesia & Analgesia 2025, 141: 522-530. PMID: 40816252, DOI: 10.1213/ane.0000000000007619.Peer-Reviewed Original ResearchConceptsAnesthesiology Clinical Trial Networks in the United States: A Report from the Anesthesia Research Council
Hua M, Billings F, Aziz M, Dutton R, Kheterpal S, Legrand M, Leslie K, Mathew J, McCann M, Subramaniam B, Treggiari M, Wijeysundera D, Gropper M. Anesthesiology Clinical Trial Networks in the United States: A Report from the Anesthesia Research Council. Anesthesiology 2025, 143: 509-517. PMID: 40793804, DOI: 10.1097/aln.0000000000005624.Peer-Reviewed Original ResearchAltmetricConcepts“Service” versus “Education” in Anesthesiology: Domain Classification of Activities Based on Perceptions from Learners and Teachers
Li J, Lin H, Yanez N, He Z, Treggiari M, Kurup V. “Service” versus “Education” in Anesthesiology: Domain Classification of Activities Based on Perceptions from Learners and Teachers. Advances In Medical Education And Practice 2025, 16: 1359-1369. PMID: 40800219, PMCID: PMC12339236, DOI: 10.2147/amep.s527329.Peer-Reviewed Original ResearchCitationsConceptsEducational valuePerceptions of educational valueLearning climateTraining activitiesHigh educational valueClassroom activitiesEducational experienceTeachersLearnersExploratory factor analysisEducationDomains of activityMandatory tasksCompletion ratesMedical educationLearningTraining programFactor analysisQuality of graduate medical educationPerceptionCross-sectional surveyGraduate Medical EducationClassroomAnesthesiology training programsClassification of activitiesEarly Vasopressor Utilization in Critically Ill Patients With Acute Traumatic Spinal Cord Injury: A Retrospective Cohort Study.
Hashemaghaie M, Ohnuma T, Sajdeya R, Khandelwal S, Yanez N, Krishnamoorthy V, Raghunathan K, Devinney M, Depuru A, Treggiari M. Early Vasopressor Utilization in Critically Ill Patients With Acute Traumatic Spinal Cord Injury: A Retrospective Cohort Study. Critical Care Medicine 2025 PMID: 40693862, DOI: 10.1097/ccm.0000000000006791.Peer-Reviewed Original ResearchCitationsConceptsSpinal cord injuryAcute traumatic spinal cord injuryTraumatic spinal cord injuryLonger hospital lengthSkilled nursing facilityCord injuryCervical spinal cord injuryHigher injury severitySpinal cord injury patientsHospital length of stayNursing facilitiesLonger hospital length-of-stayInjury Severity ScoreResidual confoundingRetrospective cohort studyLength of stayU.S. hospitalsHealthcare databasesCohort studyDischarge dispositionHospital outcomesPremier Healthcare DatabasePrimary outcomeAcute spinal cord injuryInjury severityReview of cannabis use and propofol anesthesia: recent insights and clinical implications
Sajdeya R, Treggiari M, Narouze S. Review of cannabis use and propofol anesthesia: recent insights and clinical implications. Current Opinion In Anaesthesiology 2025, 38: 660-668. PMID: 40583839, PMCID: PMC12342965, DOI: 10.1097/aco.0000000000001548.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsCannabis useChronic cannabis useCannabis use assessmentClinical implicationsCannabis usersPostponing elective surgeryClinical guidelinesPostoperative management strategiesClinically relevant considerationsComprehensive preoperative assessmentPropofol anesthesiaExplanatory mechanismsDose adjustmentPharmacodynamic pathwaysPotential adverse effectsPreoperative assessmentPharmacological interactionsCannabisPostoperative recoveryElective surgeryPerioperative considerationsIntraoperative monitoringAcute intoxicationGeneral anesthesiaPatient counselingEarly beta-blocker exposure and association with brain injury biomarkers following moderate to severe traumatic brain injury: A TRACK-TBI study.
Wongsripuemtet P, Ohnuma T, Temkin N, Barber J, Komisarow J, Manley G, Hatfield J, Treggiari M, Colton K, Sasannejad C, Chaikittisilpa N, Grandhi R, Laskowitz D, Mathew J, Hernandez A, James M, Raghunathan K, Miller J, Vavilala M, Goldstein B, Krishnamoorthy V. Early beta-blocker exposure and association with brain injury biomarkers following moderate to severe traumatic brain injury: A TRACK-TBI study. Journal Of The Intensive Care Society 2025, 17511437251349680. PMID: 40600218, PMCID: PMC12206746, DOI: 10.1177/17511437251349680.Peer-Reviewed Original ResearchConceptsNeuron-specific enolase levelsBeta-blocker exposureNeuron-specific enolaseUbiquitin C-terminal hydrolase-L1Beta-blockersC-reactive proteinBrain injury biomarkersIntensive care unitGlial fibrillary acidic proteinBiomarker levelsBB+ groupInjury biomarkersPrimary outcomeTraumatic brain injuryS100 calcium-binding protein BUCH-L1 levelsCalcium-binding protein BInflammatory biomarkers C-reactive proteinPropensity-weighted modelsRetrospective cohort studyPropensity-weighted analysisBiomarkers C-reactive proteinPotential neuroprotective effectsFibrillary acidic proteinRandomized Controlled TrialsOpioid Dose Variation in Cardiac Surgery: A Multicenter Study of Practice
Fisher C, Janda A, Zhao X, Deng Y, Bardia A, Yanez N, Burns M, Aziz M, Treggiari M, Mathis M, Lin H, Schonberger R. Opioid Dose Variation in Cardiac Surgery: A Multicenter Study of Practice. Anesthesia & Analgesia 2025, 140: 1016-1027. PMID: 39167548, PMCID: PMC11842693, DOI: 10.1213/ane.0000000000007128.Peer-Reviewed Original ResearchCitationsAltmetricConceptsCardiac surgeryOpioid doseDose variationIntraoperative opioid administrationIntraoperative opioid doseHigh-dose opioidsAdult cardiac surgerySurgical differencesOpioid-freeOpioid administrationOpioid useMultimodal analgesiaAnalgesic techniquesCardiopulmonary bypassMulticenter studyFentanyl equivalentsSufentanil infusionSurgical patientsOpioidSurgeryAnesthetic techniqueCardiac casesAttending anesthesiologistPatientsDoseTreatment with Manganese Porphyrin, MnTnBuOE-2-PyP5+, Suppressed the Activation of Macrophages in a Mouse Intracerebral Hemorrhage
Zhang S, Cao J, Spasojevic I, Treggiari M, Sheng H. Treatment with Manganese Porphyrin, MnTnBuOE-2-PyP5+, Suppressed the Activation of Macrophages in a Mouse Intracerebral Hemorrhage. Pharmaceuticals 2025, 18: 547. PMID: 40283982, PMCID: PMC12030109, DOI: 10.3390/ph18040547.Peer-Reviewed Original ResearchCitationsConceptsMouse intracerebral hemorrhageIntracerebral hemorrhageActivation of macrophagesNeurological deficitsBMX-001Hemorrhage sizeBody weightSham surgery miceMnTnBuOE-2-PyP5+Neurological deficit scoreExperimental ischemic strokePrussian blue stainingAnti-inflammatory effectsStroke patientsPost-ICHNo significant differenceNeurological outcomeC57BL6 miceSurgery miceHemorrhagic transformationClinical trialsHemorrhageRotarod testDeficit scoresHistological evaluation
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