Miriam Genuth, PhD
Associate Research Scientist, Molecular, Cellular and Developmental BiologyAbout
Research
Publications
2023
Automated time-lapse data segmentation reveals in vivo cell state dynamics
Genuth M, Kojima Y, Jülich D, Kiryu H, Holley S. Automated time-lapse data segmentation reveals in vivo cell state dynamics. Science Advances 2023, 9: eadf1814. PMID: 37267354, PMCID: PMC10413672, DOI: 10.1126/sciadv.adf1814.Peer-Reviewed Original ResearchConceptsCell statesSingle-cell RNA sequencing dataCell state dynamicsCell behaviorEmbryonic development proceedsCell state transitionsRNA sequencing dataCollective cell behaviorIndividual cell behaviorsZebrafish tailbudLeft-right asymmetryCell tracking dataCollective cell motionGene expressionSequencing dataMolecular processesIndividual embryosDevelopment proceedsEmbryosCell motionParallel identificationBilateral symmetryReproducible patternTailbudState transitions
2022
OligoTRAFTACs: A generalizable method for transcription factor degradation
Samarasinghe KTG, An E, Genuth MA, Chu L, Holley SA, Crews CM. OligoTRAFTACs: A generalizable method for transcription factor degradation. RSC Chemical Biology 2022, 3: 1144-1153. PMID: 36128504, PMCID: PMC9428672, DOI: 10.1039/d2cb00138a.Peer-Reviewed Original ResearchTranscription factorsOncogenic transcription factorGene expression circuitryTranscription factor degradationDNA binding abilityChordoma cell linesProteasomal degradationProteasomal pathwayZebrafish experimentsC-MycGeneralizable platformKey playersCell linesBrachyurySmall moleculesFactor degradationBinding abilityGeneralizable methodDegradationChimerasPathwayOligonucleotidePocketFirst generation
2018
Chick cranial neural crest cells use progressive polarity refinement, not contact inhibition of locomotion, to guide their migration.
Genuth MA, Allen CDC, Mikawa T, Weiner OD. Chick cranial neural crest cells use progressive polarity refinement, not contact inhibition of locomotion, to guide their migration. Dev Biol 2018, 444 Suppl 1: S252-S261. PMID: 29501457, DOI: 10.1016/j.ydbio.2018.02.016.Peer-Reviewed Original Research
2015
Cell Migration: Recoiling from an Embrace.
Genuth MA, Weiner OD. Cell Migration: Recoiling from an Embrace. Curr Biol 2015, 25: R566-8. PMID: 26126284, DOI: 10.1016/j.cub.2015.05.015.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
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Molecular, Cellular, and Developmental Biology
Yale Science Building rm 104, 260 Whitney St
New Haven, CT 06511
United States