Mika Naganawa, PhD
Research Scientist in Radiology and Biomedical ImagingDownloadHi-Res Photo
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Research Scientist in Radiology and Biomedical Imaging
Appointments
Radiology & Biomedical Imaging
Research ScientistPrimary
Other Departments & Organizations
- All Institutions
- Bioimaging Sciences
- PET Core
- Radiology & Biomedical Imaging
Education & Training
- JSPS Research Fellow PD
- National Institute of Radiological Sciences (2008)
- JSPS Research Fellow PD
- Tokyo Metropolitan Institute of Gerontology (2007)
- COE Program Researcher
- Nara Institute of Science and Technology (2005)
- PhD
- University of Tokyo, Frontier Sciences (2004)
- MS
- University of Tokyo, Frontier Sciences (2001)
- BE
- University of Tokyo, Engineering (1999)
Research
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Overview
Medical Research Interests
Biomedical Engineering; Dementia; Kinetics; Nuclear Medicine; Pharmacokinetics; Positron-Emission Tomography; Radiopharmaceuticals; Receptors, Opioid, kappa; Substance-Related Disorders
Public Health Interests
Statistical Computing; Substance Use, Addiction; Aging; Mental Health; Modeling
ORCID
0000-0002-4408-2621
Research at a Glance
Yale Co-Authors
Frequent collaborators of Mika Naganawa's published research.
Publications Timeline
A big-picture view of Mika Naganawa's research output by year.
Research Interests
Research topics Mika Naganawa is interested in exploring.
Richard Carson, PhD
Nabeel Nabulsi, PhD
Takuya Toyonaga, MD, PhD
Jean-Dominique Gallezot, PhD
Ming-Kai Chen, MD, PhD
David Matuskey, MD
113Publications
5,226Citations
Positron-Emission Tomography
Radiopharmaceuticals
Kinetics
Receptors, Opioid, kappa
Pharmacokinetics
Nuclear Medicine
Publications
2026
Optimized reference region and the effect on test-retest reliability and sensitivity to differences between Parkinson’s disease and control groups with [11C]UCB-J
Khattar N, Matuskey D, Gallezot J, Naganawa M, Holmes S, Sadabad F, Mayeli M, Esterlis I, van Dyck C, Mecca A, D’Souza D, Nabulsi N, Finnema S, Huang Y, Carson R, Toyonaga T. Optimized reference region and the effect on test-retest reliability and sensitivity to differences between Parkinson’s disease and control groups with [11C]UCB-J. Journal Of Cerebral Blood Flow And Metabolism : Official Journal Of The International Society Of Cerebral Blood Flow And Metabolism 2026, 0271678x261441071. PMID: 41960765, PMCID: PMC13068773, DOI: 10.1177/0271678x261441071.Peer-Reviewed Original ResearchAltmetricConceptsSynaptic density imaging in behavioral variant frontotemporal dementia: A comparison of 18F‐SynVesT‐1 and 18F‐FDG PET
Fesharaki‐Zadeh A, Cayir S, Ibrahim W, Yang Y, Gallezot J, Naganawa M, Wu Y, Toyonaga T, Sadabad F, O'Dell R, Pittman B, Nabulsi N, Strittmatter S, Carson R, Huang Y, van Dyck C, Mecca A, Matuskey D. Synaptic density imaging in behavioral variant frontotemporal dementia: A comparison of 18F‐SynVesT‐1 and 18F‐FDG PET. Alzheimer's & Dementia 2026, 22: e71283. PMID: 41954197, PMCID: PMC13063251, DOI: 10.1002/alz.71283.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsF-FDG positron emission tomographyPositron emission tomographyF-FDGSynaptic vesicle glycoprotein 2ABehavioral variant frontotemporal dementiaGlucose metabolismClinical standardsDegree of hypometabolismSV2A bindingSV2A positron emission tomographyDiagnostic accuracyHealthy controlsIn vivo biomarkersFrontal Assessment Battery scoresBehavioral variant frontotemporal dementia patientsSV2A imagingEmission tomographySynaptic densityFrontal cortexFrontotemporal dementiaIn vivoAnterior cingulateDisease monitoringSV2APatientsDose Reduction in Dynamic PET Imaging Using Self-Supervised Two-Step Deep Image Prior
Li A, Syed M, Naganawa M, Matuskey D, Carson R, Tang J. Dose Reduction in Dynamic PET Imaging Using Self-Supervised Two-Step Deep Image Prior. IEEE Transactions On Radiation And Plasma Medical Sciences 2026, PP: 1-1. DOI: 10.1109/trpms.2026.3671590.Peer-Reviewed Original ResearchCitationsConceptsDynamic brain PET imagingBrain PET imagingDeep Image PriorNoise reductionDynamic framesSupervised deep learningImage priorsDenoising approachDeep learningAverage noise reductionPET imagingDynamic datasetsTraining datasetImage-basedDeep imagingSuperior tradeoffFine-tuningSignal-to-noisePatient radiation exposureActivity distributionRadiotracer doseDatasetDose reductionNoiseParametric imagesDose reduction for synaptic density PET imaging in Parkinson’s disease
Li A, Naganawa M, Honhar P, Fontaine K, Gravel P, Matuskey D, Carson R, Tang J. Dose reduction for synaptic density PET imaging in Parkinson’s disease. NeuroImage 2026, 331: 121853. PMID: 41833889, DOI: 10.1016/j.neuroimage.2026.121853.Peer-Reviewed Original ResearchAltmetricConceptsHealthy controlsSubstantia nigraIn vivo quantificationPET imagingDeep imagingPET doseParkinson's diseaseFull-count dataSynaptic vesicle glycoprotein 2AC-UCB-JRecovery of correlationsDose reductionStandard doseNoise realizationsBrainstem nucleiRadiation exposureSynaptic densityRed nucleusMotor scoresDosePD patientsStatistical significanceClinical applicationBinding potentialDynamic PETNoninvasive Quantification of [18F]SynVesT-2 PET in Healthy Human Brains Using Simplified Reference Tissue Models.
Hernández-Martín N, Balayeva T, Naganawa M, Asch R, Huang Y, Carson R, Gallezot J, Cai Z. Noninvasive Quantification of [18F]SynVesT-2 PET in Healthy Human Brains Using Simplified Reference Tissue Models. Journal Of Nuclear Medicine 2026, jnumed.125.271207. PMID: 41679926, DOI: 10.2967/jnumed.125.271207.Peer-Reviewed Original ResearchAltmetricConceptsTest-retest variabilityAbsolute test-retest variabilityDistribution volume ratioCerebral blood flowRelative cerebral blood flowDistribution volume ratio valuesBlood flowSV2A densityConclusion:Results:PET imagingNondisplaceable binding potentialClinical applicationMethods: DataReference tissue modelNeurological disordersSimplified reference tissue modelSynaptic vesicle glycoprotein 2ATime-activity curvesMinimum scan durationHealthy volunteersPET scansCentrum semiovaleClinical feasibilityScan time"Pseudo-reference-based Input Function Shape" (pRef-IFS): Towards a True image-derived input function for PET kinetic modeling.
Volpi T, Naganawa M, Carson R, Hillmer A. "Pseudo-reference-based Input Function Shape" (pRef-IFS): Towards a True image-derived input function for PET kinetic modeling. Journal Of Cerebral Blood Flow And Metabolism : Official Journal Of The International Society Of Cerebral Blood Flow And Metabolism 2026, 271678x251411712. PMID: 41543053, PMCID: PMC12811094, DOI: 10.1177/0271678x251411712.Peer-Reviewed Original ResearchAltmetric
2025
Neural Signatures of Bipolar Disorder and Psychotropic Medication Effects: A Multimodal PET–MRI Study
Asch R, Fan S, Cool R, Boster S, DellaGioia N, Naganawa M, Nabulsi N, Lacadie C, Pietrzak R, Esterlis I. Neural Signatures of Bipolar Disorder and Psychotropic Medication Effects: A Multimodal PET–MRI Study. Biological Psychiatry 2025 PMID: 41325959, PMCID: PMC12981349, DOI: 10.1016/j.biopsych.2025.11.018.Peer-Reviewed Original ResearchAltmetricConceptsGray matter volumeBipolar disorderMedication effectsNeural signaturesPsychotropic medicationsFronto-limbic brain regionsAssociated with greater impulsivityPositron emission tomographyC]UCB-J positron emission tomographyNeurobiology of bipolar disorderSynaptic densitySynaptic vesicle glycoprotein 2AIllness-related changesMatter volumeSV2A densityBD individualsBrain regionsFunctional MRIBrain structuresGroup differencesSynaptic deficitsNeuroimaging findingsPET-MRI studiesMedical statusIn vivo evidenceMeasuring Dopamine Transporter Availability and Synaptic Density in Parkinson's Disease: A Dual‐Tracer Positron Emission Tomography Imaging Study
Sadabad F, Volpi T, Honhar P, Tinaz S, Dias M, Toyonaga T, Naganawa M, Gallezot J, Yang Y, Ibrahim W, Pittman B, Cayir S, Radhakrishnan R, Angarita G, Holmes S, Comley R, Carson R, Finnema S, Matuskey D. Measuring Dopamine Transporter Availability and Synaptic Density in Parkinson's Disease: A Dual‐Tracer Positron Emission Tomography Imaging Study. Movement Disorders 2025, 40: 2678-2687. PMID: 41040062, DOI: 10.1002/mds.70041.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsC-UCB-JDopamine transporterHealthy controlsVentral striatumDisease stageSubstantia nigraSynaptic densityParkinson's diseaseDopamine transporter availabilityPositron emission tomography imaging studiesSynaptic vesicle glycoprotein 2AAssessment of synaptic densityDopaminergic denervationBetween-group differencesTransporter availabilityBinding potentialNigrostriatal regionDisease durationDual-tracerImaging studiesPatientsPET imagingPresynaptic degenerationPD patientsDopaminePET imaging evidence of HDAC6 suppression in the amygdala across species in PTSD
Bonomi R, Naganawa M, McRiley D, Toyonaga T, LeVasseur B, Duman C, Huang Y, Matuskey D, Carson R, Pietrzak R, Girgenti M, Cosgrove K. PET imaging evidence of HDAC6 suppression in the amygdala across species in PTSD. Molecular Psychiatry 2025, 30: 5381-5388. PMID: 40753309, DOI: 10.1038/s41380-025-03124-8.Peer-Reviewed Original ResearchCitationsAltmetricConceptsPosttraumatic stress disorderPathophysiology of posttraumatic stress disorderNon-trauma-exposed controlsAmygdala of individualsProlonged stress modelBrain imaging studiesStress disorderRodent findingsNuclear translocation of glucocorticoid receptorTranslocation of glucocorticoid receptorHuman findingsTranslational findingsCortisol signalingAmygdalaGlucocorticoid receptorComplex disorderImaging studiesDisordersLongitudinal analysisStress modelHistone deacetylase 6Pharmacological targetsHistone deacetylasesFindingsNuclear translocationAssessment of test-retest reproducibility by [18F]Bavarostat for PET imaging of HDAC6
Naganawa M, Zheng M, Gallezot J, Bonomi R, Gu J, Gao H, Jacutin-Porte S, Nabulsi N, Koole M, Van Laere K, Matuskey D, Huang Y, Carson R. Assessment of test-retest reproducibility by [18F]Bavarostat for PET imaging of HDAC6. EJNMMI Research 2025, 15: 76. PMID: 40542929, PMCID: PMC12182542, DOI: 10.1186/s13550-025-01268-w.Peer-Reviewed Original ResearchCitationsAltmetricConceptsAbsolute test-retest variabilityMultilinear analysis-1Time-activity curvesTest-retest variabilityRegional time-activity curvesTest-retest reproducibilityVT valuesTwo-tissue compartment modelEffect of scan durationInterscan intervalRegional VT valuesTest-retest scansScan durationArterial blood samplesBrain bindingOne-tissuePET/CT scannerCentrum semiovaleDistribution volumePET imagingAnalysis-1Blood samplesTherapeutic targetBrain regionsHDAC6 inhibitors
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