Michael Paidas, MD
Professor AdjunctAbout
Titles
Professor Adjunct
Biography
Dr. Paidas is the recipient of The David J. Leffell, M.D. Prize for Clinical Excellence at Yale in 2010, given to one member of Yale Medicine annually. In 2012, Dr. Paidas received the Dean’s Award from the Tufts Medical Alumni Association. Dr. Paidas is included in the top 1% physician by specialty in the nation according to US News and World Report. He has been recognized by the March of Dimes and is included in Best Doctors in America. Dr. Paidas has also received the National Faculty Award by the Counsel on Resident Education in Obstetrics and Gynecology.
Dr. Paidas received his medical degree from Tufts University School of Medicine in 1987 and completed his internship and residency in Obstetrics and Gynecology in 1991 at Pennsylvania Hospital. In 1993, Dr. Paidas completed a Fellowship in Maternal Fetal Medicine at the Mount Sinai School of Medicine in New York. In 2013, Dr. Paidas was awarded a Master of Arts, Honorary Degree, from Yale University.
Dr. Paidas's career in medicine has focused on women’s health with special emphasis on blood disorders, reproduction, pregnancy complications and the latter’s impact on health and disease. His activities span direct patient care, translational research and clinical trials. Dr. Paidas’s research has been supported by federal and non- federal funding agencies. His notable contributions include: description of the regulatory factors of the Protein C system; clinical use of recombinant antithrombin in disease states; elucidation of the subsequent cardiovascular and non-cardiovascular health consequences of hypertensive disorders and preterm delivery in the largest population based studies published to date.
Dr. Paidas and collaborators have described the genomic and proteomic effects of Preimplantation Factor (PIF), a novel mammalian embryo derived factor which regulates maternal receptivity to pregnancy and possesses key immune modulatory properties. Subsequent animal studies using a synthetic analogue of native PIF have shown benefit in animal models related to a variety of immune diseases, including multiple sclerosis and graft versus host disease.
Dr. Paidas is the lead Principal Investigator of a multicenter preeclampsia treatment clinical trial, entitled Prospective Randomized Double-Blind, Placebo Controlled Evaluation of the Pharmacokinetics, Safety and Efficacy of Recombinant Antithrombin Versus Placebo in Preterm Preeclampsia (PRESERVE-1).
Dr. Paidas has expertise in prenatal ultrasound, invasive fetal diagnostic and therapeutic procedures. His academic profile includes over 500 published manuscripts, abstracts, books, chapters, presentations or courses.
Education & Training
- MA
- Yale University, Honorary Degree (2013)
- Fellow
- Mount Sinai Medical Center (1993)
- Resident
- Pennsylvania Hospital (1991)
- MD
- Tufts University School of Medicine (1987)
- BS
- Fairfield University (1982)
Research
Overview
Dr. Paidas’s notable contributions include: description of the regulatory factors of the Protein C system; clinical use of recombinant antithrombin in disease states; elucidation of the subsequent cardiovascular and non-cardiovascular health consequences of hypertensive disorders and preterm delivery in the largest population based studies published to date.
Dr. Paidas and collaborators have described the genomic and proteomic effects of Preimplantation Factor (PIF), a novel mammalian embryo derived factor which regulates maternal receptivity to pregnancy and possesses key immune modulatory properties. Subsequent animal studies using a synthetic analogue of native PIF have shown benefit in animal models related to a variety of immune diseases, including multiple sclerosis and graft versus host disease.
Dr. Paidas is the lead Prinicipal Investigator of a multicenter preeclampsia treatment clinical trial, entitled Prospective Randomized Double-Blind, Placebo Controlled Evaluation of the Pharmacokinetics, Safety and Efficacy of Recombinant Antithrombin Versus Placebo in Preterm Preeclampsia (PRESERVE-1).
Dr. Paidas has expertise in prenatal ultrasound, invasive fetal diagnostic and therapeutic procedures. His academic profile includes over 500 published manuscripts, abstracts, books, chapters, presentations or courses.
“Multigate Doppler with Global Acquisition and Signal Processing (G.A.S.P.) in the uteroplacental and fetal circulations.” This new non-invasive Doppler ultrasound technology is being applied to a variety of areas concerning women’s health, including early pregnancy assessment and gynecologic malignancy screening. This project is a collaboration between the Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, Department of Obstetrics and Gynecology; University of Milan, Bicocca, Milan, Italy; Department of Engineering, University of Florence, Florence, Italy; Esaote, Florence, Italy.
“Antithrombin levels preceding placenta mediated complications.” The objective of this study is to determine antithrombin and Preimplantation Factor levels in pregnancy complications, prior to the onset of clinical disease.
“Preimplantation factor (PIF): a biomarker for viable embryo selection after in vitro fertilization and for pregnancy outcome.” This proposal is a multicenter study which investigates the potential role of Preimplantation Factor as a diagnostic test in two settings; namely, to predict IVF success when measured in embryo culture media, and to predict viable pregnancy and a range of placenta mediated complications.
“Predicting Late and Early Perinatal Stroke in High Risk Pregnancies And High Risk Neonates.” The goal is to identify a very high risk population for perinatal stroke suitable for prevention or early treatment.
“Prospective Randomized Double-Blind, Placebo Controlled Evaluation of the Pharmacokinetics, Safety and Efficacy of Recombinant Antithrombin Versus Placebo in Pre-term Pre-eclampsia (PRESERVE-1): RB AT PPE-01-13. Funding Agency: rEVO Biologics (formerly GTC Biotherapeutics). This is a multicenter, randomized, placebo controlled trial to determine whether maternal administration of recombinant antithrombin will prolong gestational age in the setting of preeclampsia at 24 to less than 28 wks.
“Neural Stem Cells and synthetic Preimplantation Factor (sPIF) to treat perinatal brain injury in the rodent. PreImplantation-Factor (PIF) +/- neural stem cells will be investigated as a therapeutic option to treat perinatal brain injury.
Medical Research Interests
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Elizabeth Triche
Katherine Harper Campbell, MD, MPH
Nina Stachenfeld, PhD
Angelique Bordey, PhD
Dhasakumar Navaratnam, MD, PhD
Joseph Santos-Sacchi, PhD
Thrombophilia
Pregnancy Complications, Hematologic
Pre-Eclampsia
Pregnancy Complications
Pregnancy Complications, Cardiovascular
Antithrombin III Deficiency
Publications
2024
Neighborhood Food Access in Early Life and Trajectories of Child Body Mass Index and Obesity
Aris I, Wu A, Lin P, Zhang M, Farid H, Hedderson M, Zhu Y, Ferrara A, Chehab R, Barrett E, Carnell S, Camargo C, Chu S, Mirzakhani H, Kelly R, Comstock S, Strakovsky R, O’Connor T, Ganiban J, Dunlop A, Dabelea D, Breton C, Bastain T, Farzan S, Call C, Hartert T, Snyder B, Santarossa S, Cassidy-Bushrow A, O’Shea T, McCormack L, Karagas M, McEvoy C, Alshawabkeh A, Zimmerman E, Wright R, McCann M, Wright R, Coull B, Amutah-Onukagha N, Hacker M, James-Todd T, Oken E, Smith P, Newby L, Adair L, Jacobson L, Catellier D, McGrath M, Douglas C, Duggal P, Knapp E, Kress A, Blackwell C, Mansolf M, Lai J, Ho E, Cella D, Gershon R, Macy M, Das S, Freedman J, Mallal S, McLean J, Shah R, Shilts M, Alshawabkeh A, Cordero J, Meeker J, Trasande L, Camargo C, Hasegawa K, Zhu Z, Sullivan A, Dabelea D, Perng W, Bekelman T, Wilkening G, Magzamen S, Moore B, Starling A, Rinehart D, Koinis Mitchell D, D'Sa V, Deoni S, Mueller H, Duarte C, Monk C, Canino G, Posner J, Murray T, Lugo-Candelas C, Dunlop A, Brennan P, Hockett C, Elliott A, Ferrara A, Croen L, Hedderson M, Ainsworth J, Bacharier L, Bendixsen C, Gern J, Gold D, Hartert T, Jackson D, Johnson C, Joseph C, Kattan M, Khurana Hershey G, Lemanske, Jr. R, Lynch S, Miller R, O’Connor G, Ober C, Ownby D, Rivera-Spoljaric K, Ryan P, Seroogy C, Singh A, Wood R, Zoratti E, Habre R, Farzan S, Gilliland F, Hertz-Picciotto I, Bennett D, Schweitzer J, Schmidt R, LaSalle J, Hipwell A, Keenan K, Karr C, Bush N, LeWinn K, Sathyanarayana S, Zhao Q, Tylavsky F, Carroll K, Loftus C, Leve L, Ganiban J, Neiderhiser J, Weiss S, Litonjua A, McEvoy C, Spindel E, Tepper R, Newschaffer C, Lyall K, Volk H, Landa R, Ozonoff S, Piven J, Hazlett H, Pandey J, Schultz R, Dager S, Botteron K, Messinger D, Stone W, Ames J, O'Connor T, Miller R, Oken E, Hacker M, James-Todd T, O'Shea T, Fry R, Frazier J, Singh R, Rollins C, Montgomery A, Vaidya R, Joseph R, Washburn L, Gogcu S, Bear K, Rollins J, Hooper S, Taylor G, Jackson W, Thompson A, Daniels J, Hernandez M, Lu K, Msall M, Lenski M, Obeid R, Pastyrnak S, Jensen E, Sakai C, Santos H, Kerver J, Paneth N, Barone C, Elliott M, Ruden D, Fussman C, Herbstman J, Margolis A, Schantz S, Geiger S, Aguiar A, Tabb K, Strakovsky R, Woodruff T, Morello-Frosch R, Padula A, Stanford J, Porucznik C, Giardino A, Wright R, Wright R, Collett B, Baumann-Blackmore N, Gangnon R, McKennan C, Wilson J, Altman M, Aschner J, Stroustrup A, Merhar S, Moore P, Pryhuber G, Hudak M, Reynolds Lyndaker A, Lampland A, Rochelson B, Jan S, Blitz M, Katzow M, Brown Z, Chiuzan C, Rafael T, Lewis D, Meirowitz N, Poindexter B, Gebretsadik T, Osmundson S, Straughen J, Eapen A, Cassidy-Bushrow A, Wegienka G, Sitarik A, Woodcroft K, Urquhart A, Levin A, Johnson-Hooper T, Davidson B, Ma T, Barrett E, Blaser M, Dominguez-Bello M, Horton D, Jimenez M, Rosen T, Palomares K, Avalos L, Zhu Y, Hunt K, Newman R, Bloom M, Alkis M, Roberts J, Mumford S, Burris H, DeMauro S, Yee L, Hamvas A, Olidipo A, Haddad A, Eiland L, Spillane N, Suri K, Fisher S, Goldstein J, Mithal L, DeRegnier R, Maitre N, Nguyen R, JaKa M, Sidebottom A, Paidas M, Potter J, Ruby N, Duthely L, Jayakumar A, Young K, Maldonado I, Miller M, Slaughter J, Keim S, Lynch C, Venkatesh K, Whitworth K, Symanski E, Northrup T, Mendez-Figueroa H, Mosquera R, Karagas M, Madan J, MacKenzie D, Lewis J, Rennie B, Leventhal B, Kim Y, Bishop S, Nozadi S, Luo L, Lester B, Marsit C, Everson T, Loncar C, McGowan E, Sheinkopf S, Carter B, Check J, Helderman J, Neal C, Smith L. Neighborhood Food Access in Early Life and Trajectories of Child Body Mass Index and Obesity. JAMA Pediatrics 2024, 178: 1172-1182. PMID: 39283628, PMCID: PMC11406455, DOI: 10.1001/jamapediatrics.2024.3459.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsChild body mass indexLow food accessBody mass indexNeighborhood food accessChild obesityObesity riskLow-incomeFood accessAccess neighborhoodsAssociated with higher BMI z-scoreHigher BMI z-scoreBody mass index z-scoreHigher risk of obesityPrevent child obesityHigher obesity riskGeocoded residential addressesIndividual sociodemographic characteristicsBMI z-scoreRisk of obesityZ-scoreImprove food accessLow-income neighborhoodsExposure in early lifeSevere obesityEarly lifeMechanism of Alzheimer type II astrocyte development in hepatic encephalopathy
Tong X, Norenberg M, Paidas M, Shamaladevi N, Salgueiro L, Jaszberenyi M, John B, Hussain H, El Hiba O, Abdeljalil E, Bilal E, Natarajan S, Romaguera R, Papayan S, Carden A, Ramamoorthy R, Elumalai N, Schally A, Nithura J, Patrizio R, Jayakumar A. Mechanism of Alzheimer type II astrocyte development in hepatic encephalopathy. Neurochemistry International 2024, 180: 105866. PMID: 39369794, DOI: 10.1016/j.neuint.2024.105866.Peer-Reviewed Original ResearchConceptsType C HEMotor deficitsChronic liver failureHuman post-mortem brain sectionsLiver failureC HEInflammatory factorsOxidative/nitrosative stressPost-mortem brain sectionsIncreased levelsType C hepatic encephalopathyDeficitsMotor disturbancesLevels of inflammatory factorsTreatment in vitroTAA-treated ratsBrain sectionsLevels of GFAPHistopathological findingsIncreased oxidative/nitrosative stressHepatic encephalopathyW-7Pharmacological inhibitionAstrocyte culturesMotorP-438 Association of uterine cavity immune cells at the time of frozen embryo transfer with live birth
Rodriguez S, Ibrahim M, Padula L, Fisher E, Rivas K, Paidas M, Strbo N, Attia G. P-438 Association of uterine cavity immune cells at the time of frozen embryo transfer with live birth. Human Reproduction 2024, 39: deae108.787. DOI: 10.1093/humrep/deae108.787.Peer-Reviewed Original ResearchConceptsTiming of frozen embryo transferFrozen embryo transferImprove pregnancy ratesT regulatory cellsLive birthsEmbryo transferImmune cellsPregnancy rateUterine segmentInfluence implantationUltrasound guidanceUterine milieuEndometrial receptivityElective single embryo transferFc receptor-positive cellsUpper uterusTotal immune cellsLower uterine segmentInstitutional review board approvalLive-born infantsSingle embryo transferImmune cell profilesLive birth rateGamma delta TCRImmune cell subsetsPostmenopausal Pregnancy Via Oocyte Donor and Suspected Focal Placenta Accreta: A Case Report
Hajjar R, Cooper S, Elumalai N, Hussain H, Patrizio R, Sinno A, Ahmad A, Marbin S, Ruiz-Cordero R, Paidas M, Jayakumar A. Postmenopausal Pregnancy Via Oocyte Donor and Suspected Focal Placenta Accreta: A Case Report. Cureus 2024, 16: e62332. PMID: 38882221, PMCID: PMC11178238, DOI: 10.7759/cureus.62332.Peer-Reviewed Original ResearchAltmetricConceptsFocal placenta accretaPlacenta accreta spectrumPlacenta accretaPostmenopausal womenSuperimposed pre-eclampsiaAdvanced maternal agePresence of inflammatory cellsChronic kidney injuryHigher prevalence of medical comorbiditiesIn vitro fertilizationPrevalence of medical comorbiditiesCongested blood vesselsAssisted reproductive technologyCesarean deliveryPlacenta previaUterine surgeryPlacental pathologyPre-eclampsiaChronic hypertensionPlacental healthPlacental homeostasisPlacental architectureChorionic villiMaternal ageKidney injurySPIKENET: An Evidence-Based Therapy for Long COVID
Elumalai N, Hussain H, Sampath N, Shamaladevi N, Hajjar R, Druyan B, Rashed A, Ramamoorthy R, Kenyon N, Jayakumar A, Paidas M. SPIKENET: An Evidence-Based Therapy for Long COVID. Viruses 2024, 16: 838. PMID: 38932130, PMCID: PMC11209161, DOI: 10.3390/v16060838.Peer-Reviewed Original ResearchAltmetricConceptsCarcinoembryonic antigen-related cell adhesion molecule 1Murine hepatitis virus-1Post-acute sequelae of COVID-19SARS-CoV-2 variantsSARS-CoV-2Development of severe inflammationCell adhesion molecule 1Long-term complicationsAdhesion molecule 1Multiple organ damagePotential therapeutic benefitMultiple SARS-CoV-2 variantsEvidence-based therapiesSequelae of COVID-19ACE2 receptor-binding domainSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Severe inflammationTissue edemaOrgan damageRespiratory syndrome coronavirus 2Long COVIDMolecule 1Receptor-binding domainSyndrome coronavirus 2Acute and Long COVID Intestinal Changes in an Experimental Model of Coronavirus in Mice
Hussain H, Elumalai N, Sampath N, Shamaladevi N, Hajjar R, Druyan B, Rashed A, Ramamoorthy R, Kenyon N, Jayakumar A, Paidas M. Acute and Long COVID Intestinal Changes in an Experimental Model of Coronavirus in Mice. Viruses 2024, 16: 832. PMID: 38932125, PMCID: PMC11209276, DOI: 10.3390/v16060832.Peer-Reviewed Original ResearchAltmetricConceptsMurine hepatitis virus-1Inflammatory bowel diseaseCeliac diseaseImmune cell infiltrationDevelopment of targeted therapeutic strategiesGoblet cell hyperplasiaHistopathological alterationsRestore tissue homeostasisAmeliorating inflammatory responsesLung complicationsGastrointestinal complicationsMucosal inflammationLymphoid hyperplasiaCell hyperplasiaCardiovascular abnormalitiesMurine modelCell infiltrationInflammatory profileRestore tissue architectureVillous atrophyEpithelial integrityMouse modelPathological featuresTherapeutic strategiesExposure to SARS-CoV-2Blood pressure responses to handgrip exercise but not apnea or mental stress are enhanced in women with a recent history of preeclampsia
Berbrier D, Adler T, Leone C, Paidas M, Stachenfeld N, Usselman C. Blood pressure responses to handgrip exercise but not apnea or mental stress are enhanced in women with a recent history of preeclampsia. AJP Heart And Circulatory Physiology 2024, 327: h140-h154. PMID: 38700469, DOI: 10.1152/ajpheart.00020.2024.Peer-Reviewed Original ResearchCitationsAltmetricConceptsMuscle sympathetic nerve activitySystolic blood pressureResponse to acute stimuliIsometric handgrip exercise protocolMental stressHandgrip exercise protocolCardiovascular diseaseExercise-induced increaseEffective prevention strategiesAcute stimuliExercise protocolHistory of preeclampsiaBlood pressureIntegrated muscle sympathetic nerve activityElevated long-term riskElevated cardiovascular riskLong-term riskEnd-expiratory apneaSympathetic nerve activityPrevention strategiesHandgrip exerciseBlood pressure responseRisk factorsExaggerated pressorHealthy pregnancyThe Necessity of Type and Screen Result Prior to Proceeding to Operating Room for Scheduled Cesarean Delivery in a Low Hemorrhage Risk Population [ID 2683392]
Hoffmann E, Druyan B, Fletcher M, Ridore M, Paidas M, Toledo P. The Necessity of Type and Screen Result Prior to Proceeding to Operating Room for Scheduled Cesarean Delivery in a Low Hemorrhage Risk Population [ID 2683392]. Obstetrics And Gynecology 2024, 143: 52s-53s. DOI: 10.1097/01.aog.0001013676.39387.ba.Peer-Reviewed Original ResearchConceptsScheduled cesarean deliveryCesarean deliveryBlood transfusionHemorrhage scoreOperating roomIRB-approved retrospective cohort studyTime of blood transfusionTransfused intra-operativelyRetrospective cohort studyChart reviewIntra-operativelyPhysician dissatisfactionCohort studyTransfusionRisk populationPatientsOR delaysBloodScreening resultsScoresMandatory typeDeliveryFinancial ramificationsScreeningHemorrhageAssessment of immune cells in the uterine fluid at the time of the embryo transfer
Strbo N, Rodriguez S, Padula L, Fisher E, Lyons A, Rodriguez C, Rivas K, Ibrahim M, Paidas M, Attia G. Assessment of immune cells in the uterine fluid at the time of the embryo transfer. American Journal Of Reproductive Immunology 2024, 91: e13842. PMID: 38650366, DOI: 10.1111/aji.13842.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsGamma delta T cellsFrozen embryo transferLower uterusAssisted reproductive technologyIn vitro fertilizationTransfer catheterT cellsEmbryo transferTime of implantationImmune milieuUpper uterusImmune cellsUltrasound guidanceExpression of CD4+ T cellsAssessment of immune cellsImprove IVF outcomesCD8+ T cellsCD4+ T cellsPopulation of T cellsComposition of immune cellsLower uterine segmentTime of embryo transferExpression of CD3+T regulatory cellsCD3+ cellsAge and Sex in the Development of Hepatic Encephalopathy: Role of Alcohol
Tong X, Hussain H, Shamaladevi N, Norenberg M, Fadel A, Hiba O, Abdeljalil E, El-Mansoury B, Kempuraj D, Natarajan S, Schally A, Jaszberenyi M, Salgueiro L, Paidas M, Jayakumar A. Age and Sex in the Development of Hepatic Encephalopathy: Role of Alcohol. Biology 2024, 13: 228. PMID: 38666840, PMCID: PMC11048384, DOI: 10.3390/biology13040228.Peer-Reviewed Original ResearchCitationsConceptsFemale ratsMiddle-aged ratsAged male ratsAged female ratsBehavioral deficitsType C HEHepatic encephalopathyBrain edemaTAA-induced HELiver failureAged malesAged femalesMale ratsBehavioral changesAdult ratsChronic HEDevelopment of hepatic encephalopathySustained plasma levelsAcute liver failureMiddle-agedEtOHAcute HEC HEBrainDrug-induced
Academic Achievements & Community Involvement
activity Society for Maternal Fetal Medicine
CommitteesPublic OfficialDetailsContributor2009 - Presentactivity International Stillbirth Alliance
CommitteesMemberDetailsScientific Advisory Committee, member, International Stillbirth Alliance2007 - Presentactivity Centers for Disease Control
CommitteesMemberDetailsFetal and Infant Mortality Review (FIMR) of Greater New Haven, member2003 - Presentactivity National Institutes of Health
Peer Review Groups and Grant Study SectionsMemberDetailsNational Institutes of Health, invited member of a voluntary registry for reviewers2008 - Presentactivity Canadian Institutes of Health Research
Peer Review Groups and Grant Study SectionsReviewerDetailsRandomized Controlled Trials Committee, CIHR (Canadian Institutes of Health Research), Invited Reviewer2005 - Present
News & Links
News
- November 01, 2015Source: New Haven Register
Drug could help symptoms of preeclampsia
- May 29, 2015Source: WTNH
Clinical study for preeclampsia underway at Yale
- February 02, 2015
New Yale Center to advance understanding of life-threatening preeclampsia
- September 09, 2014
Brain injuries no match for sPIF treatment