Meredith Gwin
she/her/hers
Postdoctoral FellowDownloadHi-Res Photo
About
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Titles
Postdoctoral Fellow
Departments & Organizations
Education & Training
- PhD
- University of South Alabama Whiddon College of Medicine, Physiology and Cell Biology (2023)
- BS
- University of Mobile, Biology (2016)
- AA
- Coastal Alabama Community College , Liberal Arts (2014)
- AS
- Coastal Alabama Community College , General Studies (2014)
Research
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Overview
Public Health Interests
Aging; Chronic Diseases; COVID-19; Emerging Infectious Diseases; Infectious Diseases; Respiratory Disease/Infections
ORCID
0000-0002-3084-8032
Research at a Glance
Publications Timeline
A big-picture view of Meredith Gwin's research output by year.
8Publications
Publications
2025
Carbonic anhydrase IX promotes acute lung injury and mortality in females during metabolic acidosis and pneumonia.
Stevens RP, Holston J, Maatouk K, Zhou C, Stone M, Pastukh VV, Francis CM, Kumar S, Gwin MS, Sayner SL, Stevens T, Lee JY. Carbonic anhydrase IX promotes acute lung injury and mortality in females during metabolic acidosis and pneumonia. Am J Physiol Lung Cell Mol Physiol 2025, 329: L266-L281. PMID: 40623021, DOI: 10.1152/ajplung.00331.2024.Peer-Reviewed Original Research In Press
2023
Gamma secretase activating protein promotes end-organ dysfunction after bacterial pneumonia.
Gwin MS, Alexeyev MF, Geurts AM, Lee JY, Zhou C, Yang XM, Cohen MV, Downey JM, Barrington RA, Spadafora D, Audia JP, Frank DW, Voth S, Pastukh VV, Bell J, Ayers L, Tambe DT, Nelson AR, Balczon R, Lin MT, Stevens T. Gamma secretase activating protein promotes end-organ dysfunction after bacterial pneumonia. Am J Physiol Lung Cell Mol Physiol 2023, 325: L174-L189. PMID: 37366533, DOI: 10.1152/ajplung.00018.2023.Peer-Reviewed Original ResearchInfection promotes Ser-214 phosphorylation important for generation of cytotoxic tau variants.
Balczon R, Choi CS, deWeever A, Zhou C, Gwin MS, Kolb C, Francis CM, Lin MT, Stevens T. Infection promotes Ser-214 phosphorylation important for generation of cytotoxic tau variants. FASEB J 2023, 37: e23042. PMID: 37358817, DOI: 10.1096/fj.202300620RR.Peer-Reviewed Original ResearchPFKFB3 Inhibits Fructose Metabolism in Pulmonary Microvascular Endothelial Cells.
Lee JY, Stevens RP, Pastukh VV, Pastukh VM, Kozhukhar N, Alexeyev MF, Reisz JA, Nerguizian D, D'Alessandro A, Koloteva A, Gwin MS, Roberts JT, Borchert GM, Wagener BM, Pittet JF, Graham BB, Stenmark KR, Stevens T. PFKFB3 Inhibits Fructose Metabolism in Pulmonary Microvascular Endothelial Cells. Am J Respir Cell Mol Biol 2023 PMID: 37201952, DOI: 10.1165/rcmb.2022-0443OC.Peer-Reviewed Original Research
2022
Cytotoxic tau released from lung microvascular endothelial cells upon infection with Pseudomonas aeruginosa promotes neuronal tauopathy.
Choi CS, Gwin M, Voth S, Kolb C, Zhou C, Nelson AR, deWeever A, Koloteva A, Annamdevula NS, Murphy JM, Wagener BM, Pittet JF, Lim SS, Balczon R, Stevens T, Lin MT. Cytotoxic tau released from lung microvascular endothelial cells upon infection with Pseudomonas aeruginosa promotes neuronal tauopathy. J Biol Chem 2022, 298: 101482. PMID: 34896150, DOI: 10.1016/j.jbc.2021.101482.Peer-Reviewed Original Research
2021
Carbonic Anhydrase IX and Hypoxia Promote Rat Pulmonary Endothelial Cell Survival during Infection.
Lee JY, Stevens RP, Kash M, Alexeyev MF, Balczon R, Zhou C, Renema P, Koloteva A, Kozhukhar N, Pastukh V, Gwin MS, Voth S, deWeever A, Wagener BM, Pittet JF, Eslaamizaad Y, Siddiqui W, Nawaz T, Clarke C, Fouty BW, Audia JP, Alvarez DF, Stevens T. Carbonic Anhydrase IX and Hypoxia Promote Rat Pulmonary Endothelial Cell Survival during Infection. Am J Respir Cell Mol Biol 2021, 65: 630-645. PMID: 34251286, DOI: 10.1165/rcmb.2020-0537OC.Peer-Reviewed Original Research
2020
Virulent Pseudomonas aeruginosa infection converts antimicrobial amyloids into cytotoxic prions.
Voth S, Gwin M, Francis CM, Balczon R, Frank DW, Pittet JF, Wagener BM, Moser SA, Alexeyev M, Housley N, Audia JP, Piechocki S, Madera K, Simmons A, Crawford M, Stevens T. Virulent Pseudomonas aeruginosa infection converts antimicrobial amyloids into cytotoxic prions. FASEB J 2020, 34: 9156-9179. PMID: 32413239, DOI: 10.1096/fj.202000051RRR.Peer-Reviewed Original ResearchPneumonia-induced endothelial amyloids reduce dendritic spine density in brain neurons.
Scott AM, Jager AC, Gwin M, Voth S, Balczon R, Stevens T, Lin MT. Pneumonia-induced endothelial amyloids reduce dendritic spine density in brain neurons. Sci Rep 2020, 10: 9327. PMID: 32518286, DOI: 10.1038/s41598-020-66321-1.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
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Activities
activity American Thoracic Society
08/01/2017 - PresentProfessional OrganizationsMemberactivity American Heart Association
2019 - 2020Professional OrganizationsPrincipal InvestigatorDetailsPI on an predoctoral fellowship awarded for 2 years.
News
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Get In Touch
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Contacts
Mailing Address
Pulmonary, Critical Care & Sleep Medicine
1 Gilbert St, TAC
New Haven, CT 06510
United States