Margaret Pisani, MD, MPH, FCCP
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View Doctor ProfileAdditional Titles
Vice Chief Faculty Mentoring and Career Development, Pulmonary - PCCM - Critical Care
Contact Info
Pulmonary, Critical Care & Sleep Medicine
PO Box 208057, 300 Cedar Street
New Haven, CT 06520-8057
United States
Are You a Patient?
View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.
View Doctor ProfileAdditional Titles
Vice Chief Faculty Mentoring and Career Development, Pulmonary - PCCM - Critical Care
Contact Info
Pulmonary, Critical Care & Sleep Medicine
PO Box 208057, 300 Cedar Street
New Haven, CT 06520-8057
United States
Are You a Patient?
View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.
View Doctor ProfileAdditional Titles
Vice Chief Faculty Mentoring and Career Development, Pulmonary - PCCM - Critical Care
Contact Info
Pulmonary, Critical Care & Sleep Medicine
PO Box 208057, 300 Cedar Street
New Haven, CT 06520-8057
United States
About
Titles
Professor of Internal Medicine (Pulmonary, Critical Care & Sleep Medicine)
Vice Chief Faculty Mentoring and Career Development, Pulmonary - PCCM - Critical Care
Biography
Dr. Pisani is a board certified physician who specializes in pulmonary and critical care medicine. As a clinician-investigator with expertise in pulmonary, critical care, sleep medicine and chronic disease epidemiology, Dr. Pisani’s research focuses on improving the care and outcomes of critically ill patients. She has a special interest in geriatric pulmonary and critical care medicine and outcomes in older patients. She holds an MPH in chronic disease epidemiology and brings this training and her research focus to her role as mentor for fellows and junior faculty doing clinical and translational work in pulmonary, critical care and sleep medicine. In addition, she has extensive experience in conducting longitudinal clinical research studies both in the critical care setting and the outpatient setting.
Appointments
Pulmonary, Critical Care & Sleep Medicine
ProfessorPrimary
Other Departments & Organizations
- Chronic Obstructive Pulmonary Disease (COPD) Program
- ICU Research Working Group
- Internal Medicine
- Pulmonary, Critical Care & Sleep Medicine
- Sleep in ICU Research Group
- Tuberculosis Program
- Winchester Center for Lung Disease
- Yale Medicine
- Yale Ventures
Education & Training
- Fellow
- Yale University School of Medicine (2001)
- MPH
- Yale School of Public Health (2001)
- Chief Resident
- Yale-New Haven Hospital (1998)
- Resident
- Yale-New Haven Hospital (1997)
- MD
- Temple University (1994)
- MS
- New Jersey Institute of Technology (1987)
- BS
- Iona College (1985)
Research
Overview
Sleep in the ICU
Treatment of ICU Delirium
Biomarkers for delirium
Outcomes of older ICU patients after critical illness
Outcomes of patients after rapid response team assessments
Outcomes after thoracic interventional procedures
Medical Research Interests
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Terrence E. Murphy, PhD
Lauren Ferrante, MD, MHS
Amy Justice, MD, PhD
Kyle Bramley, MD
Melissa Knauert, MD, PhD
Carrie A Redlich, MD, MPH, BA
Delirium
Critical Care
Sleep Deprivation
Geriatrics
Publications
2024
Feasibility of In-Hospital Administration of a Tool to Predict Persistent Post-ICU Functional Impairment Among Older ICU Survivors A Pilot Study
Stevenson J, Murphy T, Tessier-Sherman B, Pisani M, Gill T, Ferrante L. Feasibility of In-Hospital Administration of a Tool to Predict Persistent Post-ICU Functional Impairment Among Older ICU Survivors A Pilot Study. CHEST Critical Care 2024, 2: 100093. DOI: 10.1016/j.chstcc.2024.100093.Peer-Reviewed Original ResearchCitationsAltmetricConceptsRisk prediction toolsICU survivorsIn-hospital administrationOlder adultsFunctional impairmentPilot studyIn-hospital mobilityOlder ICU survivorsDevelopment of risk prediction modelsHospital-related factorsIn-hospital factorsPresence of deliriumRisk prediction modelModel discriminationPersistent functional impairmentStatistical significanceHospital settingStudy designFeasibility thresholdDaily activitiesIncreased riskInternational Consensus ConferenceConsensus conferenceSurvivorsCritical illnessEffect of a Three-Component Geriatrics Bundle on Incident Delirium among Critically Ill Older Adults: A Pilot Clinical Trial.
Ferrante L, Han L, Andrews B, Cohen A, Davis J, Gritsenko D, Lee S, Pisani M, Reed N, Rouse G, Truebig J. Effect of a Three-Component Geriatrics Bundle on Incident Delirium among Critically Ill Older Adults: A Pilot Clinical Trial. Annals Of The American Thoracic Society 2024, 21: 1333-1337. PMID: 38785442, PMCID: PMC11376353, DOI: 10.1513/annalsats.202311-963rl.Peer-Reviewed Original ResearchAltmetricChaos and Confusion: Antipsychotic Use in the ICU Within the Veterans Healthcare System During the COVID Pandemic
Murphy I, Akgun K, Burk M, Jiang R, Bryan K, Morneau K, Sutherland A, Rightnour E, Rosen A, Zavala S, Franck A, Davids B, Lee J, Wong M, Providence S, Schmitt T, Exline T, Guilbeault T, Drumright K, Klenosky B, Pisani M, Witcher P. Chaos and Confusion: Antipsychotic Use in the ICU Within the Veterans Healthcare System During the COVID Pandemic. 2024, a2717-a2717. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a2717.Peer-Reviewed Original ResearchHow Much Is Too Much? An Assessment of Intensive Care Unit Sedative Use Across the Veterans Healthcare System During the COVID-19 Pandemic
Murphy I, Akgun K, Burk M, Jiang R, Bryan K, Sutherland A, Morneau K, Rightnour E, Providence S, Zavala S, Rosen A, Franck A, Wong M, Davids B, Lee J, Schmitt T, Exline T, Guilbeault T, Drumright K, Klenosky B, Pisani M, Witcher P. How Much Is Too Much? An Assessment of Intensive Care Unit Sedative Use Across the Veterans Healthcare System During the COVID-19 Pandemic. 2024, a5032-a5032. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a5032.Peer-Reviewed Original ResearchConceptsEffect of a Three-Component Geriatrics Bundle on Incident Delirium Among Critically Ill Older Adults
Ferrante L, Han L, Andrews B, Cohen A, Davis J, Gritsenko D, Lee S, Pisani M, Reed N, Rouse G, Truebig J. Effect of a Three-Component Geriatrics Bundle on Incident Delirium Among Critically Ill Older Adults. 2024, a2721-a2721. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a2721.Peer-Reviewed Original ResearchLong-term outcomes after treatment of delirium during critical illness with antipsychotics (MIND-USA): a randomised, placebo-controlled, phase 3 trial
Mart M, Boehm L, Kiehl A, Gong M, Malhotra A, Owens R, Khan B, Pisani M, Schmidt G, Hite R, Exline M, Carson S, Hough C, Rock P, Douglas I, Feinstein D, Hyzy R, Schweickert W, Bowton D, Masica A, Orun O, Raman R, Pun B, Strength C, Rolfsen M, Pandharipande P, Brummel N, Hughes C, Patel M, Stollings J, Ely E, Jackson J, Girard T. Long-term outcomes after treatment of delirium during critical illness with antipsychotics (MIND-USA): a randomised, placebo-controlled, phase 3 trial. The Lancet Respiratory Medicine 2024, 12: 599-607. PMID: 38701817, PMCID: PMC11296889, DOI: 10.1016/s2213-2600(24)00077-8.Peer-Reviewed Original ResearchCitationsAltmetricConceptsEffects of antipsychotic treatmentCognitive impairmentAssociated with long-term cognitive impairmentTreat deliriumLong-term cognitive impairmentLong-term outcomesTreatment of deliriumCritically ill patientsAntipsychotic treatmentZiprasidone groupHaloperidol groupFollow-upQuality-of-life outcomesAssessed survivorsZiprasidoneHaloperidolAntipsychoticsCognitive outcomesTreatment group assignmentDepartment of Veterans AffairsQuality-of-lifeIll patientsPlacebo-controlledCritical illnessLong-term follow-up
2023
Trends in use of antipsychotics and psychoactive drugs in older patients after major surgery
Kim D, Lee H, Pawar A, Lee S, Park C, Levin R, Metzger E, Bateman B, Ely E, Pandharipande P, Pisani M, Hohmann S, Marcantonio E, Inouye S. Trends in use of antipsychotics and psychoactive drugs in older patients after major surgery. Journal Of The American Geriatrics Society 2023, 71: 3755-3767. PMID: 37676699, PMCID: PMC10841351, DOI: 10.1111/jgs.18580.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsUse of antipsychoticsAcademic medical centerCommunity hospitalPostoperative periodHospital typeSurgical admissionsOlder patientsMajor surgeryAtypical antipsychoticsPsychoactive drugsIntensive care unit settingRetrospective cohort studyUse of haloperidolNon-ICU settingsUse of antiepilepticsProfessional society guidelinesPostoperative deliriumPatients 65Cohort studyHospital daysHypnotic useAgonist dexmedetomidineSociety guidelinesUnit settingMedical CenterComparative Safety Analysis of Oral Antipsychotics for In-Hospital Adverse Clinical Events in Older Adults After Major Surgery : A Nationwide Cohort Study.
Kim D, Lee S, Park C, Levin R, Metzger E, Bateman B, Ely E, Pandharipande P, Pisani M, Jones R, Marcantonio E, Inouye S. Comparative Safety Analysis of Oral Antipsychotics for In-Hospital Adverse Clinical Events in Older Adults After Major Surgery : A Nationwide Cohort Study. Annals Of Internal Medicine 2023, 176: 1153-1162. PMID: 37665998, PMCID: PMC10625498, DOI: 10.7326/m22-3021.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsTransient ischemic attackAdverse clinical eventsHospital deathMajor surgeryClinical eventsPostoperative deliriumCohort studyOlder patientsAntipsychotic drugsArrhythmia eventsCardiac arrhythmia eventsHospital adverse clinical eventsModerate-dose treatmentPremier Healthcare DatabaseHospital adverse eventsNationwide cohort studyRetrospective cohort studyAtypical antipsychotic useOral antipsychotic drugsSignificant differencesHaloperidol useIschemic attackOral antipsychoticsAdverse eventsOral haloperidol
2016
Life-Threatening Amlodipine Overdose in an Obese Male
Israel R, Lemieux S, Chernova I, Pisani M. Life-Threatening Amlodipine Overdose in an Obese Male. CHEST Journal 2016, 150: 372a. DOI: 10.1016/j.chest.2016.08.385.Peer-Reviewed Original ResearchCitationsAltmetricDexmedetomidine for hyperactive delirium: worth further study
Knauert MP, Pisani MA. Dexmedetomidine for hyperactive delirium: worth further study. Journal Of Thoracic Disease 2016, 8: e999-e1002. PMID: 27747045, PMCID: PMC5059358, DOI: 10.21037/jtd.2016.08.14.Commentaries, Editorials and LettersCitationsConceptsRisk factorsIntensive care unit patientsLength of ICUHistory of hypertensionCare unit patientsManagement of painPre-existing dementiaSeverity of illnessClinical practice guidelinesCritical care issuesHigher healthcare costsHistory of alcoholismLong-term cognitionPoor ICU outcomesCritical care medicineICU incidenceICU medicationsIntravenous haloperidolHospital stayHyperactive deliriumICU deliriumAdult patientsUnit patientsMechanical ventilationICU outcomes
Clinical Trials
Current Trials
Crystalloid Liberal or Vasopressors Early Resuscitation in Sepsis (CLOVERS)
HIC ID2000023369RoleSub InvestigatorPrimary Completion Date05/04/2022Recruiting ParticipantsGenderBothAge18+ years
Academic Achievements & Community Involvement
activity American College of Chest Physicians (ACCP)
Meeting Planning and ParticipationChairDetailsWoman's Health Network10/19/2019 - Presentactivity American Board of Internal Medicine Critical Care Exam Committee
Professional OrganizationsChairDetails07/01/2020 - Presentactivity BAISL (Better Assessment in Severe Illness) Delirium Expert Panel
Peer Review Groups and Grant Study SectionsExpert Panel MemberDetails2015 - Presentactivity American Board of Internal Medicine, Critical Care Medicine Board Exam Committee
CommitteesMemberDetails2015 - Presentactivity Center of excellence for Delirium in Aging:Research, Training and Educational Enhancement (CEDARTREE)
Peer Review Groups and Grant Study SectionsExecutive Committee MemberDetails2013 - Present
Clinical Care
Overview
Margaret Pisani, MD, MPH, is a pulmonologist and critical care specialist.
Dr. Pisani’s research focuses on improving care and outcomes for critically ill patients. She studies delirium and sleep in the intensive care unit. She has a special interest in geriatric pulmonary and critically ill patients. In addition, she is interested in how sex and gender impact lung diseases and critical illness.
In 2021, Dr. Pisani received the CHEST College Medalist Award from the American College of Chest Physicians, bringing her career full circle. A grant from CHEST was what kick-started her research career.
Dr. Pisani is a professor of medicine (pulmonary, critical care, and sleep medicine) at Yale School of Medicine.
Clinical Specialties
Board Certifications
Critical Care Medicine (Internal Medicine)
- Certification Organization
- AB of Internal Medicine
- Latest Certification Date
- 2024
- Original Certification Date
- 2001
Pulmonary Disease
- Certification Organization
- AB of Internal Medicine
- Latest Certification Date
- 2020
- Original Certification Date
- 2000
Yale Medicine News
Are You a Patient?
View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.
View Doctor ProfileNews & Links
News
- November 25, 2024
Celebrating Leadership and Education: Yale Faculty Recognized at CHEST Annual Meeting
- October 24, 2024
Carolyn M. Mazure Receives Elga R. Wasserman Award
- August 14, 2024
Sleep Deprivation in the ICU
- June 11, 2024
How Can Artificial Intelligence Advance Medical Education and Research to Transform Patient Care?
Social Media
Related Links
Get In Touch
Contacts
Pulmonary, Critical Care & Sleep Medicine
PO Box 208057, 300 Cedar Street
New Haven, CT 06520-8057
United States
Administrative Support
Locations
The Anlyan Center
Academic Office
300 Cedar Street, Ste 425C
New Haven, CT 06519
Business Office
203.785.3207Fax
203.785.5952Patient Care Locations
Are You a Patient? View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.