Mallory Locklear, PhD
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Managing Editor—Science, Research, and EducationDownloadHi-Res Photo
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Managing Editor—Science, Research, and Education
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- Office of Communications
- YSM Editorial Leadership
Education & Training
- PhD
- Stony Brook University (2014)
Research
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Publications
2024
Androgen effects on mesoprefrontal dopamine systems in the adult male brain
Kritzer M, Adler A, Locklear M. Androgen effects on mesoprefrontal dopamine systems in the adult male brain. Neuroscience 2024, 568: 519-534. PMID: 38977069, DOI: 10.1016/j.neuroscience.2024.07.001.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsDopamine circuitsDopamine systemPrefrontal cortexPrefrontal dopamine levelsPrefrontal cortical dysfunctionPrefrontal dysfunctionPrefrontal functionAdult male brainDopamine levelsCortical dysfunctionMale brainFemale brainNeuropsychiatric diseasesSex differencesCandidate mechanismsCortical operationsAndrogen modulationDopamineCortexParkinson's diseaseBrainWorking modelStates of hypo-Animal modelsSchizophrenia
2016
Gonadectomy but not biological sex affects burst‐firing in dopamine neurons of the ventral tegmental area and in prefrontal cortical neurons projecting to the ventral tegmentum in adult rats
Locklear M, Michaelos M, Collins W, Kritzer M. Gonadectomy but not biological sex affects burst‐firing in dopamine neurons of the ventral tegmental area and in prefrontal cortical neurons projecting to the ventral tegmentum in adult rats. European Journal Of Neuroscience 2016, 45: 106-120. PMID: 27564091, DOI: 10.1111/ejn.13380.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsVentral tegmental areaMesolimbic dopamine systemPrefrontal cortical neuronsTegmental areaDopamine systemPrefrontal cortexDopamine neuronsActivity of PFC neuronsDopamine cell firingVentral midbrain dopamine neuronsMidbrain dopamine neuronsTop-down modulationGonadectomized male ratsBurst firingSex hormone modulationDopamine activityDopamine tonePFC neuronsMotivational processesPrefrontal cellsVentral tegmentumDopamine levelsNeuropsychiatric disordersSex differencesCell firing
2014
Local N-methyl-d-aspartate receptor antagonism in the prefrontal cortex attenuates spatial cognitive deficits induced by gonadectomy in adult male rats
Locklear M, Bhamidipaty S, Kritzer M. Local N-methyl-d-aspartate receptor antagonism in the prefrontal cortex attenuates spatial cognitive deficits induced by gonadectomy in adult male rats. Neuroscience 2014, 288: 73-85. PMID: 25545712, PMCID: PMC4323667, DOI: 10.1016/j.neuroscience.2014.12.032.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsN-methyl-D-aspartate receptorsSpatial working memoryPrefrontal cortexAdult male ratsBarnes maze testBilateral infusionsCognitive deficitsMaze testMale ratsSpatial cognitionNMDAR-mediated activationGonadectomized ratsInfusion of APVN-methyl-D-aspartate receptor antagonismN-methyl-D-aspartate receptor antagonistSpatial cognitive deficitsSpatial search strategiesGonadally intact controlsN-methyl-D-aspartateEffect of APVWorking memoryEffects of gonadal steroidsAPV infusionBehavioral flexibilityPsychiatric illnessInitial subjective reward: single-exposure conditioned place preference to alcohol in mice
Grisel J, Beasley J, Bertram E, Decker B, Duan C, Etuma M, Hand A, Locklear M, Whitmire M. Initial subjective reward: single-exposure conditioned place preference to alcohol in mice. Frontiers In Neuroscience 2014, 8: 345. PMID: 25408633, PMCID: PMC4219544, DOI: 10.3389/fnins.2014.00345.Peer-Reviewed Original ResearchCitationsAltmetricConceptsConditioned place preference paradigmPlace preference paradigmEffects of alcoholPreference paradigmSubjective rewardRobust preferenceAt-risk individualsExcessive drinkingPharmacogenetic approachAbsence of animal modelsChronic useEnd stage diseaseAt-riskFemale subjectsStage diseaseAnimal modelsDrug AdministrationAlcoholEndophenotypesAddictionDrugRewardBrainEtOHAdultsSex Differences Distinguish Intracortical Glutamate Receptor-Mediated Regulation of Extracellular Dopamine Levels in the Prefrontal Cortex of Adult Rats
Locklear M, Cohen A, Jone A, Kritzer M. Sex Differences Distinguish Intracortical Glutamate Receptor-Mediated Regulation of Extracellular Dopamine Levels in the Prefrontal Cortex of Adult Rats. Cerebral Cortex 2014, 26: 599-610. PMID: 25260707, PMCID: PMC4712796, DOI: 10.1093/cercor/bhu222.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAnalysis of VarianceAnimalsBenzylaminesBicucullineChromatography, High Pressure LiquidDialysisDopamineEstrous CycleExcitatory Amino Acid AgentsExtracellular FluidFemaleGABA AgentsGABA-A Receptor Antagonistsgamma-Aminobutyric AcidMalePhosphinic AcidsPrefrontal CortexQuinoxalinesRatsRats, Sprague-DawleyReceptors, GlutamateSex DifferentiationSodium Channel BlockersTetrodotoxinTime FactorsValineConceptsN-methyl-D-aspartate antagonismPFC DA levelsN-methyl-D-aspartatePrefrontal cortex DAPrefrontal cortexDA levelsGABA-BPrefrontal cortex of adult ratsSex differencesA-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acidBaseline DA levelsExtracellular dopamine levelsRegulation of extracellular dopamine levelsRat prefrontal cortexCortex of adult ratsExecutive functionLocal dopamineDA homeostasisDopamine levelsGlutamatergic mechanismsDopamineDA effectsDrug effectsDA measuresFemale ratsAssessment of the effects of sex and sex hormones on spatial cognition in adult rats using the Barnes maze
Locklear M, Kritzer M. Assessment of the effects of sex and sex hormones on spatial cognition in adult rats using the Barnes maze. Hormones And Behavior 2014, 66: 298-308. PMID: 24937438, PMCID: PMC4127089, DOI: 10.1016/j.yhbeh.2014.06.006.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsBarnes mazeSpatial cognitionReference memorySpatial working memoryGDX male ratsSpatial reference memorySpatial learning strategiesTestosterone propionateRetention deficitsWorking memoryAcquisition trialsGDX ratsMnemonic differencesSpatial workingEffects of sexMazeSex differencesSerial searchCognitionMale ratsAdult ratsMemoryDeficitsGDxTask
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