2022
Developmental history modulates adult olfactory behavioral preferences via regulation of chemoreceptor expression in Caenorhabditiselegans
Kyani-Rogers T, Philbrook A, McLachlan I, Flavell S, O’Donnell M, Sengupta P. Developmental history modulates adult olfactory behavioral preferences via regulation of chemoreceptor expression in Caenorhabditiselegans. Genetics 2022, 222: iyac143. PMID: 36094348, PMCID: PMC9630977, DOI: 10.1093/genetics/iyac143.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsDiacetylGene Expression Regulation, DevelopmentalLarvaOlfactory Receptor NeuronsSmellConceptsChemoreceptor genesDAF-16 FOXO transcription factorODR-10FOXO transcription factorsDistinct gene expression profilesGene expression profilesDauer arrestChemoreceptor expressionDauer stageAWA neuronsDauer larvaeC. elegansTranscription factorsTranscriptional profilingBehavioral plasticityPosttranscriptional mechanismsTranscriptional upregulationAdult physiologyExpression patternsExpression profilesSorted populationsBehavioral preferencesVolatile odorantsCaenorhabditiselegansReceptor regulation
2021
Combinatorial Assembly of Modular Glucosides via Carboxylesterases Regulates C. elegans Starvation Survival
Wrobel C, Yu J, Rodrigues P, Ludewig A, Curtis B, Cohen S, Fox B, O’Donnell M, Sternberg P, Schroeder F. Combinatorial Assembly of Modular Glucosides via Carboxylesterases Regulates C. elegans Starvation Survival. Journal Of The American Chemical Society 2021, 143: 14676-14683. PMID: 34460264, PMCID: PMC8594405, DOI: 10.1021/jacs.1c05908.Peer-Reviewed Original ResearchMeSH KeywordsAcylationAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsCarboxylic Ester HydrolasesGlucosidesMetabolomicsOrtho-AminobenzoatesStarvationConceptsStarvation conditionsCombinatorial assemblyPremier model systemRelated nematode speciesModel organismsStarvation survivalClose homologueGenome editingBiosynthetic roleNematode speciesBiological functionsComparative metabolomicsDeletion resultsAmino acidsFirst insightModel systemMetabolite libraryLipid metabolismAdult animalsAssemblyCRISPRBiosynthesisHomologuesDularOrganisms
2020
A neurotransmitter produced by gut bacteria modulates host sensory behaviour
O’Donnell M, Fox B, Chao P, Schroeder F, Sengupta P. A neurotransmitter produced by gut bacteria modulates host sensory behaviour. Nature 2020, 583: 415-420. PMID: 32555456, PMCID: PMC7853625, DOI: 10.1038/s41586-020-2395-5.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAvoidance LearningCaenorhabditis elegansCaenorhabditis elegans ProteinsFeeding BehaviorGastrointestinal MicrobiomeIntestinesMetabolomicsMutationNeurotransmitter AgentsOctanolsOctopamineProvidenciaReceptors, Biogenic AmineReceptors, G-Protein-CoupledSensory Receptor CellsSmellTyramineTyrosine DecarboxylaseConceptsTyramine biosynthesisFood choice assaysASH nociceptive neuronsDiverse organismsCaenorhabditis elegansMutualistic relationshipComplex communitiesChoice assaysMechanistic basisHost behaviourOlfactory responsesPhysiological relevanceOctopamine receptorsGut bacteriaElegansBioactive neurotransmittersBacteriaBiosynthesisHost controlGenesNervous system activitySensory behaviorsOctopamineNociceptive neuronsProvidencia
2018
Rictor/TORC2 mediates gut-to-brain signaling in the regulation of phenotypic plasticity in C. elegans
O’Donnell M, Chao P, Kammenga J, Sengupta P. Rictor/TORC2 mediates gut-to-brain signaling in the regulation of phenotypic plasticity in C. elegans. PLOS Genetics 2018, 14: e1007213. PMID: 29415022, PMCID: PMC5819832, DOI: 10.1371/journal.pgen.1007213.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalAnimalsAnimals, Genetically ModifiedBrainCaenorhabditis elegansCaenorhabditis elegans ProteinsGene Expression Regulation, DevelopmentalIntestinal MucosaIntestinesMechanistic Target of Rapamycin Complex 2Neuronal PlasticityPhenotypeRapamycin-Insensitive Companion of mTOR ProteinSensory Receptor CellsSignal TransductionTemperatureConceptsQuantitative trait lociDauer larval stageTarget of rapamycinNematode C. elegansExternal cuesInsulin-like peptidesNeuronal functionDAF-7Phenotypic plasticityDaf-28Developmental decisionsC. elegansTrait lociCellular stressorsBacterial foodGenetic variationForaging behaviorRictor/Reproductive growthLarval developmentEnvironmental cuesNeuroendocrine gene expressionGene expressionLarval stagesFood signals
2015
Feeding state-dependent regulation of developmental plasticity via CaMKI and neuroendocrine signaling
Neal S, Takeishi A, O'Donnell M, Park J, Hong M, Butcher R, Kim K, Sengupta P. Feeding state-dependent regulation of developmental plasticity via CaMKI and neuroendocrine signaling. ELife 2015, 4: e10110. PMID: 26335407, PMCID: PMC4558564, DOI: 10.7554/elife.10110.Peer-Reviewed Original ResearchConceptsNeuroendocrine signalingDevelopmental plasticityInsulin-like peptide genesDynamic subcellular localizationDauer decisionDauer formationILP genesDauer stageDevelopmental decisionsSubcellular localizationNutrient availabilityState-dependent regulationPeptide genesReproductive cycleUnknown mechanismCaMKICMK-1SignalingGenesSensory neuronsPlasticityExpressionAWCCaenorhabditisSmall neuronal networks