Kermit 2/XGIPC, an IGF1 receptor interacting protein, is required for IGF signaling in Xenopus eye development
Wu J, O'Donnell M, Gitler A, Klein P. Kermit 2/XGIPC, an IGF1 receptor interacting protein, is required for IGF signaling in Xenopus eye development. Development 2006, 133: 3651-3660. PMID: 16914488, DOI: 10.1242/dev.02547.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsCell ProliferationCell SurvivalEyeGene Expression Regulation, DevelopmentalImmunoblottingImmunoprecipitationIn Situ HybridizationIn Situ Nick-End LabelingInsulin-Like Growth Factor INerve Tissue ProteinsPhenotypeProtein BindingProto-Oncogene Proteins c-aktReceptor, IGF Type 1Reverse Transcriptase Polymerase Chain ReactionSignal TransductionXenopusXenopus ProteinsConceptsXenopus eye developmentEye developmentPDZ domain-containing proteinsHigh amino acid similarityActive PI3-kinaseAmino acid similarityIGF1 receptorFunction phenotypesMembrane proteinsPI3-kinaseEctodermal explantsEmbryonic developmentXenopus embryosDistinct functionsEye formationNeural crestNovel componentEndogenous functionsGIPCAkt activationVivo lossPhysiological significanceIGF pathwayProteinFunction analysis