2013
Distinct functional domains of the Abelson tyrosine kinase control axon guidance responses to Netrin and Slit to regulate the assembly of neural circuits
O’Donnell M, Bashaw G. Distinct functional domains of the Abelson tyrosine kinase control axon guidance responses to Netrin and Slit to regulate the assembly of neural circuits. Development 2013, 140: 2724-2733. PMID: 23720041, PMCID: PMC3678342, DOI: 10.1242/dev.093831.Peer-Reviewed Original ResearchConceptsFunctional domainsC-terminal F-actinGuidance pathwayMidline axon crossingDistinct functional domainsAbelson tyrosine kinaseFunctional nervous systemKinase-dependent inhibitionAbl C-terminusGenetic screenMultifunctional kinaseMotor axonsNervous systemDistinct structural motifsNon-overlapping setsGuidance ligandsNeural circuitsSignaling cascadesC-terminusMidline attractionTyrosine kinaseF-actinAxon crossingAxon guidanceGuidance responses
2006
Kermit 2/XGIPC, an IGF1 receptor interacting protein, is required for IGF signaling in Xenopus eye development
Wu J, O'Donnell M, Gitler A, Klein P. Kermit 2/XGIPC, an IGF1 receptor interacting protein, is required for IGF signaling in Xenopus eye development. Development 2006, 133: 3651-3660. PMID: 16914488, DOI: 10.1242/dev.02547.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsCell ProliferationCell SurvivalEyeGene Expression Regulation, DevelopmentalImmunoblottingImmunoprecipitationIn Situ HybridizationIn Situ Nick-End LabelingInsulin-Like Growth Factor INerve Tissue ProteinsPhenotypeProtein BindingProto-Oncogene Proteins c-aktReceptor, IGF Type 1Reverse Transcriptase Polymerase Chain ReactionSignal TransductionXenopusXenopus ProteinsConceptsXenopus eye developmentEye developmentPDZ domain-containing proteinsHigh amino acid similarityActive PI3-kinaseAmino acid similarityIGF1 receptorFunction phenotypesMembrane proteinsPI3-kinaseEctodermal explantsEmbryonic developmentXenopus embryosDistinct functionsEye formationNeural crestNovel componentEndogenous functionsGIPCAkt activationVivo lossPhysiological significanceIGF pathwayProteinFunction analysis