A neurotransmitter produced by gut bacteria modulates host sensory behaviour
O’Donnell M, Fox B, Chao P, Schroeder F, Sengupta P. A neurotransmitter produced by gut bacteria modulates host sensory behaviour. Nature 2020, 583: 415-420. PMID: 32555456, PMCID: PMC7853625, DOI: 10.1038/s41586-020-2395-5.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAvoidance LearningCaenorhabditis elegansCaenorhabditis elegans ProteinsFeeding BehaviorGastrointestinal MicrobiomeIntestinesMetabolomicsMutationNeurotransmitter AgentsOctanolsOctopamineProvidenciaReceptors, Biogenic AmineReceptors, G-Protein-CoupledSensory Receptor CellsSmellTyramineTyrosine DecarboxylaseConceptsTyramine biosynthesisFood choice assaysASH nociceptive neuronsDiverse organismsCaenorhabditis elegansMutualistic relationshipComplex communitiesChoice assaysMechanistic basisHost behaviourOlfactory responsesPhysiological relevanceOctopamine receptorsGut bacteriaElegansBioactive neurotransmittersBacteriaBiosynthesisHost controlGenesNervous system activitySensory behaviorsOctopamineNociceptive neuronsProvidencia