Distinct functional domains of the Abelson tyrosine kinase control axon guidance responses to Netrin and Slit to regulate the assembly of neural circuits
O’Donnell M, Bashaw G. Distinct functional domains of the Abelson tyrosine kinase control axon guidance responses to Netrin and Slit to regulate the assembly of neural circuits. Development 2013, 140: 2724-2733. PMID: 23720041, PMCID: PMC3678342, DOI: 10.1242/dev.093831.Peer-Reviewed Original ResearchConceptsFunctional domainsC-terminal F-actinGuidance pathwayMidline axon crossingDistinct functional domainsAbelson tyrosine kinaseFunctional nervous systemKinase-dependent inhibitionAbl C-terminusGenetic screenMultifunctional kinaseMotor axonsNervous systemDistinct structural motifsNon-overlapping setsGuidance ligandsNeural circuitsSignaling cascadesC-terminusMidline attractionTyrosine kinaseF-actinAxon crossingAxon guidanceGuidance responses