2019
Dissociable Catecholaminergic Modulation of Visual Attention: Differential Effects of Catechol-O-Methyltransferase and Dopamine Beta-Hydroxylase Genes on Visual Attention
Shalev N, Vangkilde S, Neville M, Tunbridge E, Nobre A, Chechlacz M. Dissociable Catecholaminergic Modulation of Visual Attention: Differential Effects of Catechol-O-Methyltransferase and Dopamine Beta-Hydroxylase Genes on Visual Attention. Neuroscience 2019, 412: 175-189. PMID: 31195057, PMCID: PMC6645579, DOI: 10.1016/j.neuroscience.2019.05.068.Peer-Reviewed Original ResearchConceptsContinuous performance taskSustained attentionVisual attentionAttentional functionsAttentional selectionPerformance tasksEffects of catechol-O-methyltransferaseGo/No-Go taskDopamine beta-hydroxylase geneBehaviorally relevant visual informationThreshold of visual perceptionCatechol-O-methyltransferaseResponse inhibitionGo/No-GoIgnoring distractionsGenotype statusCatecholaminergic activityGroup differencesTask performanceRelevant visual informationGenes COMTBeta-hydroxylase geneCOMTDifferential effectsDopamine
2018
Encoding-related brain activity and accelerated forgetting in transient epileptic amnesia
Atherton K, Filippini N, Zeman A, Nobre A, Butler C. Encoding-related brain activity and accelerated forgetting in transient epileptic amnesia. Cortex 2018, 110: 127-140. PMID: 29861041, PMCID: PMC6335262, DOI: 10.1016/j.cortex.2018.04.015.Peer-Reviewed Original ResearchMeSH KeywordsAgedAmnesiaBrainEpilepsyFemaleHumansLearningMaleMemoryMiddle AgedNeuropsychological TestsPsychotic DisordersRecognition, PsychologyConceptsTransient epileptic amnesiaAccelerated forgettingMemory tracesBrain activityEpileptic amnesiaSyndrome of transient epileptic amnesiaEncoding-related activityAnterograde memory tasksFunctional MRI scansEncoding of memoriesVulnerable to interferenceMemory taskBrain systemsRecognition memoryHippocampal activityMemory paradigmRetention intervalMemory impairmentNeural mechanismsPoor memoryAbnormal encodingReduced deactivationWord listsHealthy control subjectsNormal performanceIncreased cerebral functional connectivity in ALS
Proudfoot M, Colclough G, Quinn A, Wuu J, Talbot K, Benatar M, Nobre A, Woolrich M, Turner M. Increased cerebral functional connectivity in ALS. Neurology 2018, 90: e1418-e1424. PMID: 29661904, PMCID: PMC5902786, DOI: 10.1212/wnl.0000000000005333.Peer-Reviewed Original ResearchConceptsAmyotrophic lateral sclerosisHealthy controlsMutation carrier groupPrimary lateral sclerosisLateral sclerosisClinical spectrumAmyotrophic lateral sclerosis pathologyPatient groupAsymptomatic carriersCerebral functional connectivityFunctional connectivityIncreased functional connectivityPosterior cingulate cortexPatientsMutations associated with amyotrophic lateral sclerosisResting-state magnetoencephalographyNeuronal oscillationsCingulate cortexCarrier groupCortical functionQuantitative markerNeuroprotective therapeuticsPresymptomatic periodSclerosisMarkers
2017
Task relevance modulates the behavioural and neural effects of sensory predictions
Auksztulewicz R, Friston K, Nobre A. Task relevance modulates the behavioural and neural effects of sensory predictions. PLOS Biology 2017, 15: e2003143. PMID: 29206225, PMCID: PMC5730187, DOI: 10.1371/journal.pbio.2003143.Peer-Reviewed Original ResearchConceptsTask-relevantMeasure participants' brain activityParticipants' brain activityInfluence of predictabilityGamma-band activityAlpha-band activityIdeal observer modelNeural effectsPredictive signalsTask demandsBrain activityNeural responsesTask performanceSpatial/temporal informationSensory predictionsVisual regionsBrain functionBehavioral responsesSpectral correlationAuditory regionsAuditory cuesInternal predictionsSubjects' predictionsVisual targetDiscrimination accuracy
2016
Sex and APOE: A memory advantage in male APOE ε4 carriers in midlife
Zokaei N, Giehl K, Sillence A, Neville M, Karpe F, Nobre A, Husain M. Sex and APOE: A memory advantage in male APOE ε4 carriers in midlife. Cortex 2016, 88: 98-105. PMID: 28086184, PMCID: PMC5333781, DOI: 10.1016/j.cortex.2016.12.016.Peer-Reviewed Original ResearchMeSH KeywordsAdultAllelesAlzheimer DiseaseApolipoprotein E4FemaleGenotypeHeterozygoteHumansMaleMemory, Short-TermMiddle AgedNeuropsychological TestsSex FactorsConceptsMedial temporal lobeMisbinding errorsShort-term memoryDelayed estimation taskE4 carriersInteraction of genderMemory advantageInfluence of APOEMeasure memoryBehavioral advantageAntagonistic pleiotropy hypothesisTemporal lobeFeature bindingMemory decaySensitive tasksAPOE e4 carriersEstimation taskMemoryMisbindingPleiotropy hypothesisMiddle-aged individualsGene dosageMidlifeAPOE genotypeAPOE allelesAltered cortical beta‐band oscillations reflect motor system degeneration in amyotrophic lateral sclerosis
Proudfoot M, Rohenkohl G, Quinn A, Colclough G, Wuu J, Talbot K, Woolrich M, Benatar M, Nobre A, Turner M. Altered cortical beta‐band oscillations reflect motor system degeneration in amyotrophic lateral sclerosis. Human Brain Mapping 2016, 38: 237-254. PMID: 27623516, PMCID: PMC5215611, DOI: 10.1002/hbm.23357.Peer-Reviewed Original ResearchConceptsPrimary lateral sclerosisAmyotrophic lateral sclerosisSensitive marker of disease activityPLS groupMotor cortex of ALS patientsBeta-band oscillationsMarkers of disease activityDevelopment of overt symptomsHealthy control groupALS spectrumAmyotrophic lateral sclerosis patientsAsymptomatic mutation carriersDiffusion tensor imaging studiesBeta desynchronizationSymptomatic patientsLateral sclerosisDisease activityMutation carriersGene mutationsCortical hyperexcitabilityAsymptomatic carriersSensitive markerNeuroprotective strategiesImaging studiesCortical dysfunctionSlow wave sleep and accelerated forgetting
Atherton K, Nobre A, Lazar A, Wulff K, Whittaker R, Dhawan V, Lazar Z, Zeman A, Butler C. Slow wave sleep and accelerated forgetting. Cortex 2016, 84: 80-89. PMID: 27710778, PMCID: PMC5084685, DOI: 10.1016/j.cortex.2016.08.013.Peer-Reviewed Original ResearchMeSH KeywordsAdultEpilepsyFemaleHumansMaleMemoryMental RecallNeuropsychological TestsSleepWakefulnessConceptsAccelerated long-term forgettingSlow wave sleepMemory benefitsAmount of slow wave sleepWord pair association taskLong-term forgettingBenefits of sleepDeclarative memoryAccelerated forgettingMemory consolidationAssociation taskMemory retentionBrain activityHealthy control groupHealthy participantsMemoryHealthy individualsElectrographic epileptiform activitySleepForgettingEpileptiform activityIndividualsSleep stagesControl groupHealthy peopleTop–Down Activation of Spatiotopic Sensory Codes in Perceptual and Working Memory Search
Kuo B, Nobre A, Scerif G, Astle D. Top–Down Activation of Spatiotopic Sensory Codes in Perceptual and Working Memory Search. Journal Of Cognitive Neuroscience 2016, 28: 996-1009. PMID: 26967943, DOI: 10.1162/jocn_a_00952.Peer-Reviewed Original ResearchConceptsFrontoparietal networkEarly visual areasMemory searchVisual areasPrioritization of relevant informationMEG dataRelevant sensory corticesLevels of processingTop-down activationDynamics of functional connectivitySensory codingN2pc effectTemporal dynamics of functional connectivityCombined fMRITarget itemsFunctional connectivityFMRI dataFrontoparietal areasCognitive systemPhase-phase couplingFMRISensory cortexInternal representationN2pcSensory inputApolipoprotein ɛ4 breaks the association between declarative long-term memory and memory-based orienting of spatial attention in middle-aged individuals
Salvato G, Patai E, McCloud T, Nobre A. Apolipoprotein ɛ4 breaks the association between declarative long-term memory and memory-based orienting of spatial attention in middle-aged individuals. Cortex 2016, 82: 206-216. PMID: 27395443, PMCID: PMC4981431, DOI: 10.1016/j.cortex.2016.06.002.Peer-Reviewed Original ResearchMeSH KeywordsAdultAllelesApolipoprotein E4AttentionCognitionFemaleGenotypeHumansMaleMemory, Long-TermMiddle AgedNeuropsychological TestsOrientation, SpatialConceptsDeclarative long-term memoryOrienting of spatial attentionLong-term memoryApo E4 genotypeSpatial attentionModulates declarative memoryMiddle-aged individualsVisuo-spatial attentionIdentification of cognitive dysfunctionAlzheimer's diseaseE4 genotypeDeclarative memoryExplicit memoryMemory deficitsAttention taskE4 carriersGrowing body of studiesCognitive dysfunctionBrain agingLate-onset Alzheimer's diseaseBody of studiesMemory systemAPOE e4 carriersBrain occurringMemoryOxford Lithium Trial (OxLith) of the early affective, cognitive, neural and biochemical effects of lithium carbonate in bipolar disorder: study protocol for a randomised controlled trial
Saunders K, Cipriani A, Rendell J, Attenburrow M, Nelissen N, Bilderbeck A, Vasudevan S, Churchill G, Goodwin G, Nobre A, Harmer C, Harrison P, Geddes J. Oxford Lithium Trial (OxLith) of the early affective, cognitive, neural and biochemical effects of lithium carbonate in bipolar disorder: study protocol for a randomised controlled trial. Trials 2016, 17: 116. PMID: 26936776, PMCID: PMC4776410, DOI: 10.1186/s13063-016-1230-7.Peer-Reviewed Original ResearchMeSH KeywordsAdultAffectAntimanic AgentsBiomarkersBipolar DisorderBrainClinical ProtocolsCognitionDouble-Blind MethodEnglandFemaleGene Expression RegulationHumansLithium CarbonateMagnetic Resonance ImagingMagnetoencephalographyMaleNeuropsychological TestsProspective StudiesPsychiatric Status Rating ScalesResearch DesignTime FactorsTreatment OutcomeYoung AdultConceptsBipolar disorderLithium trialExperimental medicine modelEffects of lithium carbonateMulti-modal investigationsMood stabilisersMood instabilityPlacebo-controlled studyCognitive testsLithium treatmentLithium carbonateDouble-blindDisordersMoodCircadian effectsMedicine modelBiochemical effectsRandomised controlled trialsTherapeutic responseParticipantsEarly effectsSide effectsClinical useFMRIEffective drugs
2015
Preserved memory-based orienting of attention with impaired explicit memory in healthy ageing
Salvato G, Patai E, Nobre A. Preserved memory-based orienting of attention with impaired explicit memory in healthy ageing. Cortex 2015, 74: 67-78. PMID: 26649914, PMCID: PMC4729287, DOI: 10.1016/j.cortex.2015.10.019.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAgingAttentionFemaleHumansMaleMemoryMiddle AgedNeuropsychological TestsOrientationVisual PerceptionYoung AdultConceptsLong-term memoryContextual long-term memoryOrienting of attentionContextual memoryExplicit memoryOlder participantsYounger participantsExplicit memory deficitsImpaired explicit memoryExplicit retrieval tasksMemory-guided attentionEncoding of eventsVisuo-spatial attentionTarget detection taskOrienting visual attentionHealthy agingMemory deficitsBehavioral performanceContextual associationsBehavioral benefitsNeural activityVisual attentionMemoryYoung adultsOlder adults
2014
Age Group and Individual Differences in Attentional Orienting Dissociate Neural Mechanisms of Encoding and Maintenance in Visual STM
Shimi A, Kuo B, Astle D, Nobre A, Scerif G. Age Group and Individual Differences in Attentional Orienting Dissociate Neural Mechanisms of Encoding and Maintenance in Visual STM. Journal Of Cognitive Neuroscience 2014, 26: 864-877. PMID: 24236697, DOI: 10.1162/jocn_a_00526.Peer-Reviewed Original ResearchConceptsVisual STMAttention negativityNeural markersMaintenance of representationsMechanisms of encodingIndividual differencesAttention positivityVisual searchNeural circuitsProspective orientationAge groupsChildrenEncodingIncome perceptionSpatial orientationAdultsN2pcNegativelyCuesPerceptuallyDevelopmentalContext of orientationAttentionItemsEEGSleep-dependent memory consolidation and accelerated forgetting
Atherton K, Nobre A, Zeman A, Butler C. Sleep-dependent memory consolidation and accelerated forgetting. Cortex 2014, 54: 92-105. PMID: 24657478, PMCID: PMC4007033, DOI: 10.1016/j.cortex.2014.02.009.Peer-Reviewed Original ResearchMeSH KeywordsEpilepsyFemaleHumansMaleMemoryMemory DisordersMiddle AgedNeuropsychological TestsRetention, PsychologySleepWakefulnessConceptsAccelerated long-term forgettingSleep-dependent memory consolidationTransient epileptic amnesiaMemory consolidationMemory retentionTEA patientsMemory consolidation processesDay of wakefulnessConsolidation of memoryLong-term forgettingNight of sleepRetention of informationMemory taskAccelerated forgettingMemory processesRetention intervalMemory impairmentCognitive performanceBehavioral assessmentSleep-dependentEpileptic amnesiaWake conditionsConsolidation processHealthy peopleMemory
2012
Power corrupts co-operation: cognitive and motivational effects in a double EEG paradigm
Kanso R, Hewstone M, Hawkins E, Waszczuk M, Nobre A. Power corrupts co-operation: cognitive and motivational effects in a double EEG paradigm. Social Cognitive And Affective Neuroscience 2012, 9: 218-224. PMID: 23160813, PMCID: PMC3907926, DOI: 10.1093/scan/nss122.Peer-Reviewed Original ResearchConceptsEffects of interpersonal powerEvent-related potential analysisExpectation of rewardPairs of participantsBehavioral accuracyAttention taskMonetary rewardsMotivational effectsEEG paradigmInterpersonal powerMotivational resourcesSubjective magnitudesRewardNeutral groupConflict detectionMonetary lossesParticipantsParadigmCo-operative performanceLevel of controlTaskSubordinatesAttentional control constrains visual short-term memory: Insights from developmental and individual differences
Astle D, Nobre A, Scerif G. Attentional control constrains visual short-term memory: Insights from developmental and individual differences. Quarterly Journal Of Experimental Psychology 2012, 65: 277-294. PMID: 20680889, PMCID: PMC4152725, DOI: 10.1080/17470218.2010.492622.Peer-Reviewed Original ResearchConceptsAttentional controlVisual short-term memory capacityVisual short-term memoryShort-term memory capacityVisual short-termWorking memory spanShort-term representationsAbsence of cuesCueing benefitsProbe itemMemory spanMnemonic representationsControl attentionOrienting attentionCue typesIndividual differencesShort-term memoryExperiment 1Experiment 2Mnemonic contentMemory capacityItem locationsCuesOrientation cuesMemory
2011
Endogenous modulation of low frequency oscillations by temporal expectations
Cravo A, Rohenkohl G, Wyart V, Nobre A. Endogenous modulation of low frequency oscillations by temporal expectations. Journal Of Neurophysiology 2011, 106: 2964-2972. PMID: 21900508, PMCID: PMC3234094, DOI: 10.1152/jn.00157.2011.Peer-Reviewed Original ResearchAge-Related Changes in Orienting Attention in Time
Zanto T, Pan P, Liu H, Bollinger J, Nobre A, Gazzaley A. Age-Related Changes in Orienting Attention in Time. Journal Of Neuroscience 2011, 31: 12461-12470. PMID: 21880908, PMCID: PMC3205974, DOI: 10.1523/jneurosci.1149-11.2011.Peer-Reviewed Original ResearchConceptsTemporal cuesOlder adultsNormal agingYoung adultsContingent negative variationTask complexityAlpha-band activityOrienting attentionAttentional resourcesBehavioral performanceNeural mechanismsAge-related changesNegative variationBand activityCuesExpectancy deficitElectroencephalographic dataDeficitsAdultsTaskResponse timeAttentionPrestimulusRelevant pointsEnhanced performanceResponse inhibition results in the emotional devaluation of faces: neural correlates as revealed by fMRI
Doallo S, Raymond J, Shapiro K, Kiss M, Eimer M, Nobre A. Response inhibition results in the emotional devaluation of faces: neural correlates as revealed by fMRI. Social Cognitive And Affective Neuroscience 2011, 7: 649-659. PMID: 21642353, PMCID: PMC3427860, DOI: 10.1093/scan/nsr031.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingResponse inhibitionNeural mechanismsBrain activityTop-down inhibitory mechanismsSocial Emotional EvaluationResponse to facesSocial-emotional networkGo/No-Go taskTask 2TASK-1Amygdala activationExecutive controlResponse-selectionBehavioral ratingsGo/No-GoInhibitory controlBrain mechanismsRating taskBehavioral measuresBrain areasResponse suppressionAffective responsesValue representationMagnetic resonance imaging
2010
The Two Sides of Temporal Orienting: Facilitating Perceptual Selection, Disrupting Response Selection
Correa Á, Cappucci P, Nobre A, Lupiáñez J. The Two Sides of Temporal Orienting: Facilitating Perceptual Selection, Disrupting Response Selection. Experimental Psychology 2010, 57: 142-148. PMID: 20178944, DOI: 10.1027/1618-3169/a000018.Peer-Reviewed Original ResearchConceptsExecutive controlTemporal orientationResolution of response conflictPerceptual stimulus featuresTemporal orienting of attentionEnhanced executive controlSpatial Stroop taskSpatial Stroop effectOrienting of attentionStroop effectResponse conflictStroop taskSimon taskSimon effectResponse selectionPerceptual conflictPerceptual selectionTarget onsetStimulus featuresFlankerResponse levelsTaskSimonCuesConflict
2009
Searching for Targets within the Spatial Layout of Visual Short-Term Memory
Kuo B, Rao A, Lepsien J, Nobre A. Searching for Targets within the Spatial Layout of Visual Short-Term Memory. Journal Of Neuroscience 2009, 29: 8032-8038. PMID: 19553443, PMCID: PMC6666054, DOI: 10.1523/jneurosci.0952-09.2009.Peer-Reviewed Original ResearchConceptsVisual short-term memoryVSTM representationsTarget itemsNeural mechanismsShort-term memoryTask goalsVisual search arrayEvent-related potentialsPerceptual arraysScalp distributionPerceptual domainVisual searchNeural activityInternal representationDegree of overlapItemsMemoryTarget objectTaskTarget selectionN2pcN2pcsSpatial layoutRepresentationFindings