2024
Neural dynamics of shifting attention between perception and working-memory contents
Gresch D, Boettcher S, Gohil C, van Ede F, Nobre A. Neural dynamics of shifting attention between perception and working-memory contents. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2406061121. PMID: 39536078, PMCID: PMC11588118, DOI: 10.1073/pnas.2406061121.Peer-Reviewed Original ResearchMeSH KeywordsAdultAttentionBrainCuesFemaleHumansMagnetoencephalographyMaleMemory, Short-TermVisual PerceptionYoung AdultConceptsAttention shiftsBrain activityNeural dynamicsPatterns of human brain activityWorking-memory taskWorking-memory contentsVisual contentInternal memory representationsWorking memoryMemory representationsSequential cuesHuman brain activityMultivariate decodingAlpha lateralizationSpatial attentionNeural statesCuesSensory environmentEveryday tasksTaskPerceptionCombined perceptionAttentionAlternative domainsMagnetoencephalographyA Neural Decision Signal during Internal Sampling from Working Memory in Humans
van Ede F, Nobre A. A Neural Decision Signal during Internal Sampling from Working Memory in Humans. Journal Of Neuroscience 2024, 44: e1475232024. PMID: 38538144, PMCID: PMC11079964, DOI: 10.1523/jneurosci.1475-23.2024.Peer-Reviewed Original ResearchMeSH KeywordsAdultCuesDecision MakingElectroencephalographyFemaleHumansMaleMemory, Short-TermPhotic StimulationReaction TimeYoung AdultConceptsWorking memoryDomains of working memoryMemory-guided behaviorEvolving decision processesInternal visual representationsNeural evidenceParietal positivitySensory evidenceMental contentMemory contentPurposeful behaviorDecision signalsTime participantsMemorySensory informationInternational sampleMultiple contentsDecision processVisual representationPsychologyDecision-making frameworkNeuroscienceEvidenceBehaviorParticipantsShifting attention between perception and working memory
Gresch D, Boettcher S, van Ede F, Nobre A. Shifting attention between perception and working memory. Cognition 2024, 245: 105731. PMID: 38278040, DOI: 10.1016/j.cognition.2024.105731.Peer-Reviewed Original ResearchConceptsWorking memoryExperiment 1Working-memory taskShifts of attentionStay trialsAttentional orientingAttention domainEveryday cognitionAttention shiftsExperiment 2Shift trialsSpatial attentionAdaptive behaviorBaseline conditionsMemoryEveryday tasksSensory stimulationSensory signalsParticipantsTaskItemsPerceptionCognitionAttentionInternal domain
2023
Time for Memories
Buonomano D, Buzsáki G, Davachi L, Nobre A. Time for Memories. Journal Of Neuroscience 2023, 43: 7565-7574. PMID: 37940593, PMCID: PMC10634580, DOI: 10.1523/jneurosci.1430-23.2023.Peer-Reviewed Original ResearchConceptsWorking memoryEpisodic memoryNeural mechanismsInfluence of episodic memoryProcess temporal informationBrain storesTemporal cognitionCognitive functionAdaptive behaviorTemporal anticipationMemoryNeural sequencesBrainSpatiotemporal codingTemporal structureComputational motifsCognitionTemporal informationRecallAnticipationEpisodesPerceptionHeading Direction Tracks Internally Directed Selective Attention in Visual Working Memory
Thom J, Nobre A, van Ede F, Draschkow D. Heading Direction Tracks Internally Directed Selective Attention in Visual Working Memory. Journal Of Cognitive Neuroscience 2023, 35: 856-868. PMID: 36802368, DOI: 10.1162/jocn_a_01976.Peer-Reviewed Original ResearchConceptsVisual working memoryWorking memorySelective attentionOrienting of attentionWorking memory delaysVirtual reality experienceCentral coloured cueGaze biasMemory delayVisual itemsNeural circuitryMemorized locationReality experienceColor cuesOrienting responseVisual representationMemorySensory informationSpatial layoutHead movementsCuesHead orientation responsesExternal environmentItemsMultiple and Dissociable Effects of Sensory History on Working-Memory Performance
Hajonides J, van Ede F, Stokes M, Nobre A, Myers N. Multiple and Dissociable Effects of Sensory History on Working-Memory Performance. Journal Of Neuroscience 2023, 43: 2730-2740. PMID: 36868858, PMCID: PMC10089243, DOI: 10.1523/jneurosci.1200-22.2023.Peer-Reviewed Original ResearchConceptsWorking-memory taskNeural activity patternsRepulsive biasSensory processingBehavioral reportsEarly sensory processing stagesWorking-memory performanceEarly sensory processingSensory processing stageLevels of sensory processingActivity patternsSensory informationPostperceptual processesStimulus encodingAttractiveness biasPostperceptual stagesNeural representationNeural activityWithin-trialEncoding orientationDissociative effectsBehavioral responsesParticipants' reportsHuman brainStimulus history
2022
Opening Questions in Visual Working Memory
Nobre A. Opening Questions in Visual Working Memory. Journal Of Cognitive Neuroscience 2022, 35: 49-59. PMID: 36166312, PMCID: PMC9832369, DOI: 10.1162/jocn_a_01920.Peer-Reviewed Original ResearchTurning Attention Inside Out: How Working Memory Serves Behavior
van Ede F, Nobre A. Turning Attention Inside Out: How Working Memory Serves Behavior. Annual Review Of Psychology 2022, 74: 137-165. PMID: 35961038, DOI: 10.1146/annurev-psych-021422-041757.Peer-Reviewed Original ResearchFunctional but not obligatory link between microsaccades and neural modulation by covert spatial attention
Liu B, Nobre A, van Ede F. Functional but not obligatory link between microsaccades and neural modulation by covert spatial attention. Nature Communications 2022, 13: 3503. PMID: 35715471, PMCID: PMC9205986, DOI: 10.1038/s41467-022-31217-3.Peer-Reviewed Original ResearchConceptsCompared to trialsSpatial attentionCovert spatial attentionModulation of alpha activityVisual working memoryModulation of neural activitySpatial modulationNeural modulationEEG alpha activityAlpha activityWorking memoryNeural signaturesNeural activityDirectional biasMemorised locationEye movementsFixational eye movementsMicrosaccadesConsequences of predictable temporal structure in multi-task situations
Gresch D, Boettcher S, Nobre A, van Ede F. Consequences of predictable temporal structure in multi-task situations. Cognition 2022, 225: 105156. PMID: 35537346, PMCID: PMC9760566, DOI: 10.1016/j.cognition.2022.105156.Peer-Reviewed Original ResearchConceptsWorking-memory taskPredictable temporal structureMemory probesTemporal expectationsVisual working-memory taskWorking-memory performanceWorking-memory contentsMemory delayUpcoming tasksTemporal structureDelay periodMulti-tasking situationsTask resultsMulti-task scenariosMulti-task settingTemporal predictionMemoryTaskEveryday lifeExpectationsMultiple spatial frames for immersive working memory
Draschkow D, Nobre A, van Ede F. Multiple spatial frames for immersive working memory. Nature Human Behaviour 2022, 6: 536-544. PMID: 35058640, PMCID: PMC7612679, DOI: 10.1038/s41562-021-01245-y.Peer-Reviewed Original Research
2021
Shielding working-memory representations from temporally predictable external interference
Gresch D, Boettcher S, van Ede F, Nobre A. Shielding working-memory representations from temporally predictable external interference. Cognition 2021, 217: 104915. PMID: 34600356, PMCID: PMC8543071, DOI: 10.1016/j.cognition.2021.104915.Peer-Reviewed Original ResearchConceptsTemporal expectationsDistractor suppressionEffects of temporal expectationVisual working-memory taskWorking-memory representationsWorking-memory taskWorking-memory contentsWorking memoryExternal sensory inputIrrelevant distractorsMemory performancePredictable distractorsDistractorsInternal representationSensory inputTemporal predictionMemoryExternal interferenceExternal eventsSafeguarding behaviorsRetention periodDaily lifeInfluence of external interferenceDetrimental influenceLooking ahead in working memory to guide sequential behaviour
van Ede F, Deden J, Nobre A. Looking ahead in working memory to guide sequential behaviour. Current Biology 2021, 31: r779-r780. PMID: 34157258, PMCID: PMC8231093, DOI: 10.1016/j.cub.2021.04.063.Peer-Reviewed Original ResearchToward a neurobiology of internal selective attention
van Ede F, Nobre A. Toward a neurobiology of internal selective attention. Trends In Neurosciences 2021, 44: 513-515. PMID: 33992457, DOI: 10.1016/j.tins.2021.04.010.Peer-Reviewed Original Research
2020
When Natural Behavior Engages Working Memory
Draschkow D, Kallmayer M, Nobre A. When Natural Behavior Engages Working Memory. Current Biology 2020, 31: 869-874.e5. PMID: 33278355, PMCID: PMC7902904, DOI: 10.1016/j.cub.2020.11.013.Peer-Reviewed Original ResearchConceptsLaboratory tasksProperties of WMWM representationsWorking memoryIncreased locomotionParticipants' avoidanceEncoding durationCognitive processesEcological validityImmersive taskCognitive systemExperimental rigorGathering informationTaskTask completionMemorySensitive measureVR approachExternal informationTemporary storageParticipantsSample informationBehaviorLocomotive demandsInformationTemporal Expectations Prepare Visual Working Memory for Behavior
Jin W, Nobre A, van Ede F. Temporal Expectations Prepare Visual Working Memory for Behavior. Journal Of Cognitive Neuroscience 2020, 32: 2320-2332. PMID: 32897120, PMCID: PMC8357348, DOI: 10.1162/jocn_a_01626.Peer-Reviewed Original ResearchMeSH KeywordsCognitionContingent Negative VariationElectroencephalographyHumansMemory, Short-TermMotivationTimeConceptsVisual working memoryWorking memoryTemporal expectationsTask demandsContext of working memoryWorking memory retentionAnticipated task demandsChange-detection taskContralateral delay activityMemory-guided behaviorInfluence of temporal expectationEEG signaturesAlpha activityAlpha lateralizationMemory retentionElectrophysiological markersBehavioral performanceDelayed activationEEG measuresEEGMemoryAlphaSuperior short-term memory in APOE ε2 carriers across the age range
Zokaei N, Board A, Slavkova E, Mackay C, Nobre A, Husain M. Superior short-term memory in APOE ε2 carriers across the age range. Behavioural Brain Research 2020, 397: 112918. PMID: 32961217, PMCID: PMC7732594, DOI: 10.1016/j.bbr.2020.112918.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAlzheimer DiseaseApolipoprotein E2FemaleHeterozygoteHumansMaleMemory, Short-TermMiddle AgedProtective FactorsPsychomotor PerformanceConceptsShort-term memoryMemory advantageAssociated with individual differencesShort-term memory taskSignificant memory advantageAlzheimer's diseaseMemory performanceIndividual differencesTask difficultyAD-related pathologyAge rangeCognitive healthE3/E3 carriersSensitive to subtle changesAt-risk cohortElderly adultsApolipoprotein E4 alleleMemoryCognitionCohort of individualsMiddle-agedDevelopment of ADE4 alleleIndividualsPhenotypic effectsGoal-directed and stimulus-driven selection of internal representations
van Ede F, Board A, Nobre A. Goal-directed and stimulus-driven selection of internal representations. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 24590-24598. PMID: 32929036, PMCID: PMC7533705, DOI: 10.1073/pnas.2013432117.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PsychologicalAdultAttentionFemaleGoalsHumansMaleMemory, Short-TermVisual PerceptionYoung AdultConceptsGoal-directedWorking memoryInternal representationInfluence memory performanceVisual working memoryMemory-guided behaviorGuidance of attentionInternal memory representationsStimulus-driven factorsStimulus-driven selectionRelevant sensory informationMemory representationsMemory performanceSelection of relevant sensory informationGaze biasStimulus-drivenAdaptive behaviorMemorySensory informationStimuliComparing the prioritization of items and feature-dimensions in visual working memory
Hajonides J, van Ede F, Stokes M, Nobre A. Comparing the prioritization of items and feature-dimensions in visual working memory. Journal Of Vision 2020, 20: 25-25. PMID: 32841318, PMCID: PMC7453048, DOI: 10.1167/jov.20.8.25.Peer-Reviewed Original ResearchConceptsVisual working memoryRetro-cueRetrospective cuesWorking memoryNeutral retro-cuesInternal sensory representationsMemory recall performancePosterior alpha oscillationsItem cuesPrioritization of itemsCueing benefitsAttentional prioritizationNeural basisRecall performanceAttentional benefitsBehavioral resultsRecall accuracyTask performanceFeature-dimensionSensory representationsItem levelAlpha oscillationsItem-basedInformation—atCuesShort-term memory advantage for brief durations in human APOE ε4 carriers
Zokaei N, Grogan J, Fallon S, Slavkova E, Hadida J, Manohar S, Nobre A, Husain M. Short-term memory advantage for brief durations in human APOE ε4 carriers. Scientific Reports 2020, 10: 9503. PMID: 32528115, PMCID: PMC7289888, DOI: 10.1038/s41598-020-66114-6.Peer-Reviewed Original ResearchConceptsApolipoprotein E4 geneE4 geneAntagonistic pleiotropy effectsAlzheimer's diseaseE4 alleleGenetic risk factorsGene poolDeleterious genesAntagonistic pleiotropyShort-term memoryGenetic variantsApolipoprotein E4 alleleEvolutionary biologyGene allelesGenesMemory advantagePleiotropic effectsAllelesPleiotropy effectsNon-carriersShort-term memory performanceAPOE e4 carriersSignificant memory advantageHuman populationHuman cognitive functions