2019
Neural markers of category-based selective working memory in aging
Mok R, O'Donoghue M, Myers N, Drazich E, Nobre A. Neural markers of category-based selective working memory in aging. NeuroImage 2019, 194: 163-173. PMID: 30905834, PMCID: PMC6547047, DOI: 10.1016/j.neuroimage.2019.03.033.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAttentionFemaleHealthy AgingHumansMagnetic Resonance ImagingMaleMemory, Short-TermMiddle AgedPrefrontal CortexConceptsWorking memoryNetwork of brain regionsConsequence of selective attentionOlder adultsFunctional magnetic resonance imagingPsychophysiological interaction analysisCategory-sensitive areasRecognition-memory taskAnterior cingulate cortexNon-sensory corticesMeasures of attentionLevel of task performanceTop-down attentionGroup of older adultsNormal cognitive functionWM spanCognitive controlWM performancePrefrontal cortexMemory measuresCingulate cortexAttentional controlMemory processesNeural measuresAttended itemsWhole-brain white matter organization, intelligence, and educational attainment
Bathelt J, Scerif G, Nobre A, Astle D. Whole-brain white matter organization, intelligence, and educational attainment. Trends In Neuroscience And Education 2019, 15: 38-47. PMID: 31176470, PMCID: PMC6556839, DOI: 10.1016/j.tine.2019.02.004.Peer-Reviewed Original ResearchConceptsNeural correlates of intelligenceGeneral cognitive abilityCorrelates of intelligenceAssociated with intelligenceTypically-developing childrenBrain network propertiesVoxel-wise analysisAssociated with educational attainmentNeural correlatesCognitive abilitiesBrain regionsConnectome organizationDevelopmental theoryEducational attainmentChildhood focusChildhoodBrainIntelligenceNetwork propertiesEducational abilitiesAttainmentAbilityConnectomeRelationshipParticipantsThe Oxford study of Calcium channel Antagonism, Cognition, Mood instability and Sleep (OxCaMS): study protocol for a randomised controlled, experimental medicine study
Atkinson L, Colbourne L, Smith A, Harmer C, Nobre A, Rendell J, Jones H, Hinds C, Mould A, Tunbridge E, Cipriani A, Geddes J, Saunders K, Harrison P. The Oxford study of Calcium channel Antagonism, Cognition, Mood instability and Sleep (OxCaMS): study protocol for a randomised controlled, experimental medicine study. Trials 2019, 20: 120. PMID: 30755265, PMCID: PMC6373140, DOI: 10.1186/s13063-019-3175-0.Peer-Reviewed Original ResearchConceptsMood instabilityExperimental medicine studiesPsychiatric disordersPlacebo-controlled experimental medicine studyL-type calcium channelsAetiology of psychiatric disordersCalcium channel antagonismBipolar disorderHealthy young adultsMoodCognitionCalcium channel geneVoltage-gated calcium channel geneYoung adultsDouble-blindMedicine studiesDisordersAntagonist nicardipineCalcium channelsSleepCACNA1CChannel genesTreat hypertensionOxford studyTherapeutic potential
2018
Temporally Unconstrained Decoding Reveals Consistent but Time-Varying Stages of Stimulus Processing
Vidaurre D, Myers N, Stokes M, Nobre A, Woolrich M. Temporally Unconstrained Decoding Reveals Consistent but Time-Varying Stages of Stimulus Processing. Cerebral Cortex 2018, 29: 863-874. PMID: 30535141, PMCID: PMC6319313, DOI: 10.1093/cercor/bhy290.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrainDecision MakingFemaleHumansMagnetic Resonance ImagingMalePhotic StimulationPsychomotor PerformanceReaction TimeYoung AdultConceptsStimulus processingStages of stimulus processingTraditional decoding approachEarly sensory areasCognitive processesNeural processesPerceptual judgmentsBrain statesTiming of statesNeural dynamicsSensory areasInvestigate learningStimuliTemporal precisionDecoding approachQuality of performanceTrialsDecision makingJudgmentTaskSpontaneous cortical activity transiently organises into frequency specific phase-coupling networks
Vidaurre D, Hunt L, Quinn A, Hunt B, Brookes M, Nobre A, Woolrich M. Spontaneous cortical activity transiently organises into frequency specific phase-coupling networks. Nature Communications 2018, 9: 2987. PMID: 30061566, PMCID: PMC6065434, DOI: 10.1038/s41467-018-05316-z.Peer-Reviewed Original ResearchConceptsHigher-order cognitive networksPatterns of oscillatory powerBrain statesCognitive networksFunctional brain networksTransient brain statesFrequency-specific oscillationsSpontaneous cortical activityDelta/theta rangeMode networkCognitive tasksResting networksBrain areasBrain networksIntrinsic timescalesOscillatory powerPosterior alphaCortical activityMotor networkAnterior subdivisionFunctional specialisationNeuronal populationsBrainBandCoherenceDecoding the influence of anticipatory states on visual perception in the presence of temporal distractors
van Ede F, Chekroud S, Stokes M, Nobre A. Decoding the influence of anticipatory states on visual perception in the presence of temporal distractors. Nature Communications 2018, 9: 1449. PMID: 29654312, PMCID: PMC5899132, DOI: 10.1038/s41467-018-03960-z.Peer-Reviewed Original ResearchConceptsAnticipatory statesTarget representationDistractor resistanceAnticipatory cuesDistractor stimuliBrain responsesPerceptual targetCognitive influencesDistractorsTarget processingVisual perceptionProtective windowStimuliMultivariate stimuliTarget decoderElectroencephalography recordingsIdentity informationState
2017
Increased rostral anterior cingulate activity following positive mental imagery training in healthy older adults
Murphy S, O’Donoghue M, Blackwell S, Nobre A, Browning M, Holmes E. Increased rostral anterior cingulate activity following positive mental imagery training in healthy older adults. Social Cognitive And Affective Neuroscience 2017, 12: 1950-1958. PMID: 29069519, PMCID: PMC5716192, DOI: 10.1093/scan/nsx120.Peer-Reviewed Original ResearchConceptsRostral anterior cingulate cortexRostral anterior cingulate cortex activationHealthy older adultsPositive imageryCognitive trainingRostral anterior cingulate activityFunctional magnetic resonance imaging scansControl trainingMental imagesAmbiguous sentences taskAnterior cingulate activityBilateral hippocampal activationAmbiguous social eventsAnterior cingulate cortexImagery trainingOlder adultsResponse to cuesConsistent with other evidenceProspective imageryCingulate activityMental imagery trainingCingulate cortexAffective episodesHippocampal activitySentence task
2016
Early behavioural facilitation by temporal expectations in complex visual-motor sequences
Heideman S, van Ede F, Nobre A. Early behavioural facilitation by temporal expectations in complex visual-motor sequences. Journal Of Physiology-Paris 2016, 110: 487-496. PMID: 28323028, PMCID: PMC5742633, DOI: 10.1016/j.jphysparis.2017.03.003.Peer-Reviewed Original ResearchMeSH KeywordsAdultFemaleHumansMagnetic Resonance ImagingMagnetoencephalographyMaleMotor SkillsPhotic StimulationPsychomotor PerformanceReaction TimeVisual PerceptionYoung AdultConceptsVisual-motor sequencesTemporal expectationsTemporal orientationReaction time differencesSpatial-temporal sequenceBehavioral facilitationBehavioral benefitsIncidental learningInter-element intervalsFacilitatory influenceBehavioral responsesIncidental acquisitionTemporal cuesLate blockMultiple presentationsSequential structureSessionsTaskCentral hypothesisParticipantsModified versionDaily lifeCuesSequence structureExpectationsTraining Working Memory in Childhood Enhances Coupling between Frontoparietal Control Network and Task-Related Regions
Barnes J, Nobre A, Woolrich M, Baker K, Astle D. Training Working Memory in Childhood Enhances Coupling between Frontoparietal Control Network and Task-Related Regions. Journal Of Neuroscience 2016, 36: 9001-9011. PMID: 27559180, PMCID: PMC4995310, DOI: 10.1523/jneurosci.0101-16.2016.Peer-Reviewed Original ResearchConceptsWorking memoryTopics of cognitive psychologyTask-related cognitive processesAssessment of working memoryFrontoparietal control networkWorking memory taskChildren's working memoryWorking memory trainingTask-related regionsInferior temporal cortexTraining working memoryUpper alpha rhythmHigh-gamma activityMemory taskMemory trainingParietal cortexTemporal cortexCognitive abilitiesCognitive processesNeural network activityMagnetoencephalography scannerChild's educational progressCognitive psychologyNeurophysiological accountDevelopmental disordersTop–Down Activation of Spatiotopic Sensory Codes in Perceptual and Working Memory Search
Kuo B, Nobre A, Scerif G, Astle D. Top–Down Activation of Spatiotopic Sensory Codes in Perceptual and Working Memory Search. Journal Of Cognitive Neuroscience 2016, 28: 996-1009. PMID: 26967943, DOI: 10.1162/jocn_a_00952.Peer-Reviewed Original ResearchConceptsFrontoparietal networkEarly visual areasMemory searchVisual areasPrioritization of relevant informationMEG dataRelevant sensory corticesLevels of processingTop-down activationDynamics of functional connectivitySensory codingN2pc effectTemporal dynamics of functional connectivityCombined fMRITarget itemsFunctional connectivityFMRI dataFrontoparietal areasCognitive systemPhase-phase couplingFMRISensory cortexInternal representationN2pcSensory inputOxford Lithium Trial (OxLith) of the early affective, cognitive, neural and biochemical effects of lithium carbonate in bipolar disorder: study protocol for a randomised controlled trial
Saunders K, Cipriani A, Rendell J, Attenburrow M, Nelissen N, Bilderbeck A, Vasudevan S, Churchill G, Goodwin G, Nobre A, Harmer C, Harrison P, Geddes J. Oxford Lithium Trial (OxLith) of the early affective, cognitive, neural and biochemical effects of lithium carbonate in bipolar disorder: study protocol for a randomised controlled trial. Trials 2016, 17: 116. PMID: 26936776, PMCID: PMC4776410, DOI: 10.1186/s13063-016-1230-7.Peer-Reviewed Original ResearchMeSH KeywordsAdultAffectAntimanic AgentsBiomarkersBipolar DisorderBrainClinical ProtocolsCognitionDouble-Blind MethodEnglandFemaleGene Expression RegulationHumansLithium CarbonateMagnetic Resonance ImagingMagnetoencephalographyMaleNeuropsychological TestsProspective StudiesPsychiatric Status Rating ScalesResearch DesignTime FactorsTreatment OutcomeYoung AdultConceptsBipolar disorderLithium trialExperimental medicine modelEffects of lithium carbonateMulti-modal investigationsMood stabilisersMood instabilityPlacebo-controlled studyCognitive testsLithium treatmentLithium carbonateDouble-blindDisordersMoodCircadian effectsMedicine modelBiochemical effectsRandomised controlled trialsTherapeutic responseParticipantsEarly effectsSide effectsClinical useFMRIEffective drugs
2015
Modulation of hippocampal theta and hippocampal‐prefrontal cortex function by a schizophrenia risk gene
Cousijn H, Tunbridge E, Rolinski M, Wallis G, Colclough G, Woolrich M, Nobre A, Harrison P. Modulation of hippocampal theta and hippocampal‐prefrontal cortex function by a schizophrenia risk gene. Human Brain Mapping 2015, 36: 2387-2395. PMID: 25757652, PMCID: PMC4672713, DOI: 10.1002/hbm.22778.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBrain MappingGenetic Predisposition to DiseaseGenotypeHippocampusHomozygoteHumansKruppel-Like Transcription FactorsMagnetic Resonance ImagingMagnetoencephalographyNeural PathwaysPolymorphism, Single NucleotidePrefrontal CortexRisk FactorsSchizophreniaTheta RhythmYoung AdultConceptsFunctional magnetic resonance imagingHippocampal thetaPrefrontal cortexFunctional connectivityAssociated with functional connectivityHippocampal networkSuperior frontal gyrusSchizophrenia risk genesTheta-band oscillationsDual regression approachNetwork coactivationsZNF804A rs1344706Frontal gyrusZNF804A polymorphismsZNF804A geneBrain regionsBrain activityZNF804ABrain functionSchizophreniaHippocampalInvestigate coactivationOscillatory activityTheta bandMagnetoencephalography
2014
Attention Biases Visual Activity in Visual Short-term Memory
Kuo B, Stokes M, Murray A, Nobre A. Attention Biases Visual Activity in Visual Short-term Memory. Journal Of Cognitive Neuroscience 2014, 26: 1377-1389. PMID: 24456394, DOI: 10.1162/jocn_a_00577.Peer-Reviewed Original ResearchConceptsVisual STMRetrospective cuesVisual short-term memoryTop-down control mechanismsTop-down attentional modulationVisual STM tasksShifts of attentionModulation of visual activityModulation of activityAreas V1-V4Relevant memorandaAttentional controlRetention intervalShort-term memoryFunctional connectivityVisual activityRetinotopic regionsAssociated with changesLarge-scale networksCuesV1-V4AttentionPFCMemoryMemorandaResting GABA and glutamate concentrations do not predict visual gamma frequency or amplitude
Cousijn H, Haegens S, Wallis G, Near J, Stokes M, Harrison P, Nobre A. Resting GABA and glutamate concentrations do not predict visual gamma frequency or amplitude. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 9301-9306. PMID: 24927588, PMCID: PMC4078853, DOI: 10.1073/pnas.1321072111.Peer-Reviewed Original ResearchMeSH KeywordsAdultBiological ClocksFemaleGamma-Aminobutyric AcidGlutamic AcidHumansMagnetic Resonance ImagingMaleMembrane PotentialsOccipital LobeRadiographyConceptsGamma peak frequencyHealthy volunteersGamma oscillationsVisual gamma activityBeamformer spatial filtering techniquesPeak frequencyCortical gamma oscillationsMagnetic resonance spectroscopyExcitatory pyramidal cellsGamma activityGamma-band oscillationsMagnetic resonance spectroscopy voxelGABAergic interneuronsMagnetic resonance spectroscopy measurementsGaussian fittingPyramidal cellsMagnetic resonance spectroscopy dataGABA levelsGamma frequenciesGABA concentrationsMeasurement of GABAGABAGlutamate concentrationOscillationsOccipital lobe
2013
Frontal and Parietal Cortical Interactions with Distributed Visual Representations during Selective Attention and Action Selection
Nelissen N, Stokes M, Nobre A, Rushworth M. Frontal and Parietal Cortical Interactions with Distributed Visual Representations during Selective Attention and Action Selection. Journal Of Neuroscience 2013, 33: 16443-16458. PMID: 24133250, PMCID: PMC3797369, DOI: 10.1523/jneurosci.2625-13.2013.Peer-Reviewed Original ResearchConceptsMultivoxel pattern analysisOccipitotemporal cortexParietal areasStimulus categoriesHuman occipitotemporal cortexPattern strengthTop-down controlVisuoperceptual tasksFrontal operculumParietal cortexAttention conditionAttentional contextFrontal regionsCategory identityAction selectionSimilar effectsQualitatively similar effectsCortexCortical interactionsStimuliConcurrent activationPattern analysisVisual representationTaskRead information
2011
Top-down modulation: bridging selective attention and working memory
Gazzaley A, Nobre A. Top-down modulation: bridging selective attention and working memory. Trends In Cognitive Sciences 2011, 16: 129-135. PMID: 22209601, PMCID: PMC3510782, DOI: 10.1016/j.tics.2011.11.014.Peer-Reviewed Original ResearchMeSH KeywordsAttentionFunctional NeuroimagingHumansMagnetic Resonance ImagingMemory, Short-TermNeural PathwaysParietal LobePrefrontal CortexPsychomotor PerformanceReaction TimeConceptsTop-down modulationSource of top-down signalsMaintenance of relevant informationParietal control regionsInfluence working memoryHuman neurophysiological studiesEncoding of stimuliTop-down signalsWM taskMemory retrievalWorking memoryCognitive operationsNeural mechanismsSelective attentionCognitive resourcesReview recent evidenceStimulus-presentCore featuresSensory cortexNeurophysiological studiesConcurrent engagementMemoryRecent evidenceStimuliActivity modulationLong-term memory prepares neural activity for perception
Stokes M, Atherton K, Patai E, Nobre A. Long-term memory prepares neural activity for perception. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 109: e360-e367. PMID: 22109554, PMCID: PMC3277524, DOI: 10.1073/pnas.1108555108.Peer-Reviewed Original ResearchMeSH KeywordsAdultAttentionBrainCortical SynchronizationElectrodesFemaleHumansMagnetic Resonance ImagingMaleMemory, Long-TermNerve NetOrientationOxygenVisual PerceptionConceptsContents of long-term memoryLong-term memoryMemory-guided attentionDorsal frontoparietal circuitFunctional MRI resultsVisual cortexExtrastriate visual cortexAlpha-band activityAttentional orientingPerceptual processingFrontoparietal circuitsOngoing perceptionNeural mechanismsPerceptual sensitivitySource of predictive informationFunctional MRINeural activityPreparatory stateCortical networksBrain statesCortexPreparatory activityPast experiencesMemorySpatial locationResponse inhibition results in the emotional devaluation of faces: neural correlates as revealed by fMRI
Doallo S, Raymond J, Shapiro K, Kiss M, Eimer M, Nobre A. Response inhibition results in the emotional devaluation of faces: neural correlates as revealed by fMRI. Social Cognitive And Affective Neuroscience 2011, 7: 649-659. PMID: 21642353, PMCID: PMC3427860, DOI: 10.1093/scan/nsr031.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingResponse inhibitionNeural mechanismsBrain activityTop-down inhibitory mechanismsSocial Emotional EvaluationResponse to facesSocial-emotional networkGo/No-Go taskTask 2TASK-1Amygdala activationExecutive controlResponse-selectionBehavioral ratingsGo/No-GoInhibitory controlBrain mechanismsRating taskBehavioral measuresBrain areasResponse suppressionAffective responsesValue representationMagnetic resonance imagingModulation of working-memory maintenance by directed attention
Lepsien J, Thornton I, Nobre A. Modulation of working-memory maintenance by directed attention. Neuropsychologia 2011, 49: 1569-1577. PMID: 21420421, DOI: 10.1016/j.neuropsychologia.2011.03.011.Peer-Reviewed Original ResearchConceptsRetro-cueEvent-related functional magnetic resonance imagingCurrent models of working memoryModel of working memoryFunctional magnetic resonance imagingWorking-memory maintenanceRelevant stimulus categoryResponse to facesCategories of stimuliMaintenance-related activitiesGoal-directed wayPrefrontal cortexWM representationsRelevant memorandaStimulus categoriesParahippocampal gyriProbe stimuliScene stimuliCue categoriesStimulus typeAssociation areasWMCategorical wayMagnetic resonance imagingStimuliImagery for shapes activates position-invariant representations in human visual cortex
Stokes M, Saraiva A, Rohenkohl G, Nobre A. Imagery for shapes activates position-invariant representations in human visual cortex. NeuroImage 2011, 56: 1540-1545. PMID: 21376815, DOI: 10.1016/j.neuroimage.2011.02.071.Peer-Reviewed Original ResearchConceptsTop-down control mechanismsMultivoxel pattern analysisLateral occipital complexHigher-level visual areasNeural codingPerceptual codingModulation of functional connectivityControl mechanismsVisual cortexHuman visual cortexVisual areasCodeVisual codesTop-down controlControl centreOccipital complexVisual cortical areasFunctional connectivitySimple shapesCentral fixationVisual imageryCortical areasGeneral modelSensory inputCortex