2023
Evidence Accumulation Rate Moderates the Relationship between Enriched Environment Exposure and Age-Related Response Speed Declines
Brosnan M, Pearce D, O’Neill M, Loughnane G, Fleming B, Zhou S, Chong T, Nobre A, Connell R, Bellgrove M. Evidence Accumulation Rate Moderates the Relationship between Enriched Environment Exposure and Age-Related Response Speed Declines. Journal Of Neuroscience 2023, 43: 6401-6414. PMID: 37507230, PMCID: PMC10500991, DOI: 10.1523/jneurosci.2260-21.2023.Peer-Reviewed Original ResearchConceptsCognitive functionBrain healthOlder adultsNeural metricsTrajectories of cognitive agingMarkers of brain healthLevel of cognitive functioningEnriched environmentEvidence accumulation ratesPreservation of cognitive functionGlobal cognitive functionInfluence of EENeurocognitive vulnerabilityCognitive agingCognitive reserveMotor processesSensory evidenceBrain activityNeurocognitive healthEvidence accumulationResponse speedBrain agingAging brainSocial stimulationSpeed decline
2020
Short-term memory advantage for brief durations in human APOE ε4 carriers
Zokaei N, Grogan J, Fallon S, Slavkova E, Hadida J, Manohar S, Nobre A, Husain M. Short-term memory advantage for brief durations in human APOE ε4 carriers. Scientific Reports 2020, 10: 9503. PMID: 32528115, PMCID: PMC7289888, DOI: 10.1038/s41598-020-66114-6.Peer-Reviewed Original ResearchConceptsApolipoprotein E4 geneE4 geneAntagonistic pleiotropy effectsAlzheimer's diseaseE4 alleleGenetic risk factorsGene poolDeleterious genesAntagonistic pleiotropyShort-term memoryGenetic variantsApolipoprotein E4 alleleEvolutionary biologyGene allelesGenesMemory advantagePleiotropic effectsAllelesPleiotropy effectsNon-carriersShort-term memory performanceAPOE e4 carriersSignificant memory advantageHuman populationHuman cognitive functions
2019
Changing Interpretations of Emotional Expressions in Working Memory With Aging
Mok R, van der Meulen J, Holmes E, Nobre A. Changing Interpretations of Emotional Expressions in Working Memory With Aging. Emotion 2019, 19: 1060-1069. PMID: 30321038, PMCID: PMC6764502, DOI: 10.1037/emo0000481.Peer-Reviewed Original ResearchConceptsWorking memoryYoung adultsInterpretation of emotional expressionsEmotion-laden stimuliAge-related impairmentFearful facesEmotional materialWM performanceWM accuracyEmotional biasExperimental tasksEmotional expressionPositive biasAffective representationsFacial expressionsOlder adultsFuture behaviorMemoryAdultsTaskBiasImpairmentStimuliPositive effectAge
2018
Anticipatory neural dynamics of spatial-temporal orienting of attention in younger and older adults
Heideman S, Rohenkohl G, Chauvin J, Palmer C, van Ede F, Nobre A. Anticipatory neural dynamics of spatial-temporal orienting of attention in younger and older adults. NeuroImage 2018, 178: 46-56. PMID: 29733953, PMCID: PMC6057272, DOI: 10.1016/j.neuroimage.2018.05.002.Peer-Reviewed Original ResearchConceptsTemporal orientationOlder adultsPosterior alphaEffect of temporal orientationBeta oscillationsEnhanced perceptual sensitivitySpatial-temporal orientationAttentional orientingPerceptual sensitivityEffect of spatial orientationOrientation taskTemporal expectationsMagnetoencephalography dataAnticipatory modulationNeural dynamicsBilateral suppressionVisual targetYoung adultsGamma bandReduced reaction timeMagnetoencephalographyVisual perceptionReaction timeCuesAdults
2017
Cognitive Training in the Elderly: Bottlenecks and New Avenues
Zokaei N, MacKellar C, Čepukaitytė G, Patai E, Nobre A. Cognitive Training in the Elderly: Bottlenecks and New Avenues. Journal Of Cognitive Neuroscience 2017, 29: 1473-1482. PMID: 27897677, DOI: 10.1162/jocn_a_01080.Peer-Reviewed Original ResearchConceptsCognitive functionCognitive trainingComputer-based cognitive trainingTargeting specific cognitive functionsSpecific cognitive functionsComprehensive assessment protocolReverse cognitive declineComputer-based interventionsSensitive batteryCognitive rehabilitationCognitive declineIndividual's abilityHealthy agingAssessment protocolTraining interventionDevelopment of measuresSpecific patternsTraining regimensCognitionBudding fieldInterventionDeficitsLack of consensusElderly population
2016
Temporal Orienting of Attention Can Be Preserved in Normal Aging
Chauvin J, Gillebert C, Rohenkohl G, Humphreys G, Nobre A. Temporal Orienting of Attention Can Be Preserved in Normal Aging. Psychology And Aging 2016, 31: 442-455. PMID: 27294712, PMCID: PMC4976797, DOI: 10.1037/pag0000105.Peer-Reviewed Original ResearchConceptsBehavioral performanceTemporal expectationsRapid serial visual presentation taskTemporal orientationTemporal orienting of attentionOrienting of attentionPredictive temporal cuesYoung adultsLong temporal intervalsReaction timeNeutral cuesTarget stimuliLong foreperiodsTarget itemsVisual discriminationPerceptual functionsOlder individualsNormal agingShort foreperiodsYounger participantsAuditory cuesTemporal cuesCuesValidity benefitsTemporal intervalsBehavioral and Neural Markers of Flexible Attention over Working Memory in Aging
Mok R, Myers N, Wallis G, Nobre A. Behavioral and Neural Markers of Flexible Attention over Working Memory in Aging. Cerebral Cortex 2016, 26: 1831-1842. PMID: 26865653, PMCID: PMC4785959, DOI: 10.1093/cercor/bhw011.Peer-Reviewed Original ResearchConceptsRetro-cueWorking memoryOlder adultsMeasured magnetoencephalographyHigher order cognitionPerformance of older adultsOrienting of attentionWM performanceCueing benefitsWM maintenanceWM representationsMitigate cognitive declineFlexible attentionMemory precisionAttentional benefitsNeural markersOscillatory powerCognitive declineNeural dynamicsMEG recordingsMemoryHealthy agingPreservation of controllabilityRelevant itemsModel-based analysis
2015
Preserved memory-based orienting of attention with impaired explicit memory in healthy ageing
Salvato G, Patai E, Nobre A. Preserved memory-based orienting of attention with impaired explicit memory in healthy ageing. Cortex 2015, 74: 67-78. PMID: 26649914, PMCID: PMC4729287, DOI: 10.1016/j.cortex.2015.10.019.Peer-Reviewed Original ResearchConceptsLong-term memoryContextual long-term memoryOrienting of attentionContextual memoryExplicit memoryOlder participantsYounger participantsExplicit memory deficitsImpaired explicit memoryExplicit retrieval tasksMemory-guided attentionEncoding of eventsVisuo-spatial attentionTarget detection taskOrienting visual attentionHealthy agingMemory deficitsBehavioral performanceContextual associationsBehavioral benefitsNeural activityVisual attentionMemoryYoung adultsOlder adultsImagining a brighter future: The effect of positive imagery training on mood, prospective mental imagery and emotional bias in older adults
Murphy S, O’Donoghue M, Drazich E, Blackwell S, Nobre A, Holmes E. Imagining a brighter future: The effect of positive imagery training on mood, prospective mental imagery and emotional bias in older adults. Psychiatry Research 2015, 230: 36-43. PMID: 26235478, PMCID: PMC4593863, DOI: 10.1016/j.psychres.2015.07.059.Peer-Reviewed Original ResearchConceptsCognitive bias modificationBias modificationOlder adultsInterpretation biasPositive affectCognitive trainingPost-trainingProspective mental imageryNegative interpretation biasBoost positive affectComputer-based cognitive trainingDecreased negative affectCognitive health outcomesOne-month follow-upProspective imageryNegative affectTrait anxietyEmotional biasMental imageryPositive imageryHealth outcomesControl trainingImagery trainingTraining groupAffect
2014
Age Group and Individual Differences in Attentional Orienting Dissociate Neural Mechanisms of Encoding and Maintenance in Visual STM
Shimi A, Kuo B, Astle D, Nobre A, Scerif G. Age Group and Individual Differences in Attentional Orienting Dissociate Neural Mechanisms of Encoding and Maintenance in Visual STM. Journal Of Cognitive Neuroscience 2014, 26: 864-877. PMID: 24236697, DOI: 10.1162/jocn_a_00526.Peer-Reviewed Original ResearchConceptsVisual STMAttention negativityNeural markersMaintenance of representationsMechanisms of encodingIndividual differencesAttention positivityVisual searchNeural circuitsProspective orientationAge groupsChildrenEncodingIncome perceptionSpatial orientationAdultsN2pcNegativelyCuesPerceptuallyDevelopmentalContext of orientationAttentionItemsEEG
2011
Age-Related Changes in Orienting Attention in Time
Zanto T, Pan P, Liu H, Bollinger J, Nobre A, Gazzaley A. Age-Related Changes in Orienting Attention in Time. Journal Of Neuroscience 2011, 31: 12461-12470. PMID: 21880908, PMCID: PMC3205974, DOI: 10.1523/jneurosci.1149-11.2011.Peer-Reviewed Original ResearchConceptsTemporal cuesOlder adultsNormal agingYoung adultsContingent negative variationTask complexityAlpha-band activityOrienting attentionAttentional resourcesBehavioral performanceNeural mechanismsAge-related changesNegative variationBand activityCuesExpectancy deficitElectroencephalographic dataDeficitsAdultsTaskResponse timeAttentionPrestimulusRelevant pointsEnhanced performance