2018
APOE genotype and cognition in healthy individuals at risk of Alzheimer's disease: A review
O'Donoghue M, Murphy S, Zamboni G, Nobre A, Mackay C. APOE genotype and cognition in healthy individuals at risk of Alzheimer's disease: A review. Cortex 2018, 104: 103-123. PMID: 29800787, DOI: 10.1016/j.cortex.2018.03.025.Peer-Reviewed Original ResearchMeSH KeywordsAlzheimer DiseaseAnimalsApolipoprotein E4CognitionCognition DisordersCognitive DysfunctionHumansMemoryConceptsNeurobiological mechanismsCognitive deficitsAPOE-e4Sensitive measures of cognitionAPOE genotypeMeasures of cognitionNon-demented adultsAlzheimer's diseaseHealthy adultsCognitive agingInfluence of APOENeurobiological processesLiterature reporting effectsCognitive effectsInfluence cognitionCognitive consequencesBehavioral evidenceCognitive differencesRisk of Alzheimer's diseaseCognitionAPOE-e4 carriersDementia pathologyInfluence of APOE genotypeProdromal periodMid-adulthoodIncreased cerebral functional connectivity in ALS
Proudfoot M, Colclough G, Quinn A, Wuu J, Talbot K, Benatar M, Nobre A, Woolrich M, Turner M. Increased cerebral functional connectivity in ALS. Neurology 2018, 90: e1418-e1424. PMID: 29661904, PMCID: PMC5902786, DOI: 10.1212/wnl.0000000000005333.Peer-Reviewed Original ResearchConceptsAmyotrophic lateral sclerosisHealthy controlsMutation carrier groupPrimary lateral sclerosisLateral sclerosisClinical spectrumAmyotrophic lateral sclerosis pathologyPatient groupAsymptomatic carriersCerebral functional connectivityFunctional connectivityIncreased functional connectivityPosterior cingulate cortexPatientsMutations associated with amyotrophic lateral sclerosisResting-state magnetoencephalographyNeuronal oscillationsCingulate cortexCarrier groupCortical functionQuantitative markerNeuroprotective therapeuticsPresymptomatic periodSclerosisMarkers
2017
Cognitive Training in the Elderly: Bottlenecks and New Avenues
Zokaei N, MacKellar C, Čepukaitytė G, Patai E, Nobre A. Cognitive Training in the Elderly: Bottlenecks and New Avenues. Journal Of Cognitive Neuroscience 2017, 29: 1473-1482. PMID: 27897677, DOI: 10.1162/jocn_a_01080.Peer-Reviewed Original ResearchConceptsCognitive functionCognitive trainingComputer-based cognitive trainingTargeting specific cognitive functionsSpecific cognitive functionsComprehensive assessment protocolReverse cognitive declineComputer-based interventionsSensitive batteryCognitive rehabilitationCognitive declineIndividual's abilityHealthy agingAssessment protocolTraining interventionDevelopment of measuresSpecific patternsTraining regimensCognitionBudding fieldInterventionDeficitsLack of consensusElderly population