2020
Purpose-Dependent Consequences of Temporal Expectations Serving Perception and Action
van Ede F, Rohenkohl G, Gould I, Nobre A. Purpose-Dependent Consequences of Temporal Expectations Serving Perception and Action. Journal Of Neuroscience 2020, 40: 7877-7886. PMID: 32900836, PMCID: PMC7548698, DOI: 10.1523/jneurosci.1134-20.2020.Peer-Reviewed Original ResearchConceptsTemporal expectationsBrain activityBrain statesFrequency-specific mannerUpcoming perceptionSources of temporal expectationsOscillatory brain activityVisual-motor taskAffected response timesNeurophysiological brain activityBehavioral relevancePerceptual accuracyNeural activityNeural lateralizationNeural statesFemale human volunteersRelevant dimensionsBrainModality-StateTaskHuman volunteersPerceptionResponse speedResponse timeOne Thing Leads to Another: Anticipating Visual Object Identity Based on Associative-Memory Templates
Boettcher S, Stokes M, Nobre A, van Ede F. One Thing Leads to Another: Anticipating Visual Object Identity Based on Associative-Memory Templates. Journal Of Neuroscience 2020, 40: 4010-4020. PMID: 32284338, PMCID: PMC7219293, DOI: 10.1523/jneurosci.2751-19.2020.Peer-Reviewed Original ResearchConceptsContingent negative variationTemporal anticipationElectrophysiological signaturesMemory templatesProbabilistic associationsNegative variationAnticipatory mechanismsAlpha oscillationsAlpha-band oscillationsField of attentionAttentional templatesMemory cuesNeural substratesPreparatory attentionTask-relevantExperiment 2Neural mechanismsBehavioral consequencesBehavioral benefitsObject identityMotor responsePerceptual identityElectrophysiological substrateHuman electrophysiologyAnticipatory states
2019
Rhythmic Temporal Expectation Boosts Neural Activity by Increasing Neural Gain
Auksztulewicz R, Myers N, Schnupp J, Nobre A. Rhythmic Temporal Expectation Boosts Neural Activity by Increasing Neural Gain. Journal Of Neuroscience 2019, 39: 9806-9817. PMID: 31662425, PMCID: PMC6891052, DOI: 10.1523/jneurosci.0925-19.2019.Peer-Reviewed Original ResearchConceptsTop-down biasRhythmic expectancyIrrelevant distractorsStimulus processingIncreased neural gainNeural sensitivityNeural gainAlignment of neural activityNeural activityTask-relevant targetsImpairing stimulus processingAuditory discrimination taskAuditory stimulus featuresRhythmic temporal expectationBehavioral discrimination accuracyIncreased neural sensitivityNeural decodingDiscrimination taskBrain activityStimulus aspectsTime pointsStimulus streamStimulus featuresTemporal expectationsTask performance
2018
Not All Predictions Are Equal: “What” and “When” Predictions Modulate Activity in Auditory Cortex through Different Mechanisms
Auksztulewicz R, Schwiedrzik C, Thesen T, Doyle W, Devinsky O, Nobre A, Schroeder C, Friston K, Melloni L. Not All Predictions Are Equal: “What” and “When” Predictions Modulate Activity in Auditory Cortex through Different Mechanisms. Journal Of Neuroscience 2018, 38: 8680-8693. PMID: 30143578, PMCID: PMC6170983, DOI: 10.1523/jneurosci.0369-18.2018.Peer-Reviewed Original ResearchConceptsNeural mechanismsNeural processesMotor areaSensory processingCortical activitySuperior temporal gyrusShort-term plasticityTiming of acoustic eventsAuditory areasMechanisms of predictionPrefrontal regionsPrefrontal areasTemporal gyrusBrain regionsManipulated predictionNeural responsesStimulus attributesStimulus featuresEncode predictionsParticipants' predictionsAdaptive behaviorEnvironmental regularitiesNeurophysiological mechanismsCortical hierarchyExperimental manipulationAnticipatory neural dynamics of spatial-temporal orienting of attention in younger and older adults
Heideman S, Rohenkohl G, Chauvin J, Palmer C, van Ede F, Nobre A. Anticipatory neural dynamics of spatial-temporal orienting of attention in younger and older adults. NeuroImage 2018, 178: 46-56. PMID: 29733953, PMCID: PMC6057272, DOI: 10.1016/j.neuroimage.2018.05.002.Peer-Reviewed Original ResearchConceptsTemporal orientationOlder adultsPosterior alphaEffect of temporal orientationBeta oscillationsEnhanced perceptual sensitivitySpatial-temporal orientationAttentional orientingPerceptual sensitivityEffect of spatial orientationOrientation taskTemporal expectationsMagnetoencephalography dataAnticipatory modulationNeural dynamicsBilateral suppressionVisual targetYoung adultsGamma bandReduced reaction timeMagnetoencephalographyVisual perceptionReaction timeCuesAdults
2017
Anticipated moments: temporal structure in attention
Nobre A, van Ede F. Anticipated moments: temporal structure in attention. Nature Reviews Neuroscience 2017, 19: 34-48. PMID: 29213134, DOI: 10.1038/nrn.2017.141.Peer-Reviewed Original ResearchConceptsTemporal expectationsObject-based attentionDomains of perceptionFeature-based expectationRelevant sensory inputAttentional biasCue associationsCognitive domainsNeural mechanismsNeural responsesCognitive disordersSynchrony of neuronal activityTemporal structureNeuronal activityTemporal attentionSensory inputFeature-basedPointsAttentionRelevant momentsAttentionPerceptionExpectationsDisordersTemporal Anticipation Based on Memory
Cravo A, Rohenkohl G, Santos K, Nobre A. Temporal Anticipation Based on Memory. Journal Of Cognitive Neuroscience 2017, 29: 2081-2089. PMID: 28777060, PMCID: PMC5884434, DOI: 10.1162/jocn_a_01172.Peer-Reviewed Original ResearchConceptsLearned temporal associationsLong-term memoryInfluence of long-term memoryAssociative memoryTarget appearanceTime of target appearanceEcological roleDiscrimination of targetsNeural mechanismsRetroactive functionTemporal predictionTemporal preparationNeural markersTemporal associationTemporal contingencyTemporal anticipationDynamic natureMemoryTemporal alignment of anticipatory motor cortical beta lateralisation in hidden visual‐motor sequences
Heideman S, van Ede F, Nobre A. Temporal alignment of anticipatory motor cortical beta lateralisation in hidden visual‐motor sequences. European Journal Of Neuroscience 2017, 48: 2684-2695. PMID: 28921756, PMCID: PMC6220967, DOI: 10.1111/ejn.13700.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnticipation, PsychologicalBeta RhythmFemaleHumansMagnetoencephalographyMaleMotor CortexPhotic StimulationReaction TimeTime PerceptionVisual PerceptionYoung AdultConceptsSerial reaction timeModified serial reaction timeUpcoming target locationVisual-motor sequencesAnticipatory preparationBehavioral benefitsBrain activityNeural dynamicsBeta oscillationsModulation of motor cortical excitabilityLateralisationSpatial-temporal sequenceMotor cortical excitabilityReaction timeComparing targetsCortical excitabilityTarget locationThe Cumulative Effects of Predictability on Synaptic Gain in the Auditory Processing Stream
Auksztulewicz R, Barascud N, Cooray G, Nobre A, Chait M, Friston K. The Cumulative Effects of Predictability on Synaptic Gain in the Auditory Processing Stream. Journal Of Neuroscience 2017, 37: 6751-6760. PMID: 28607165, PMCID: PMC5508257, DOI: 10.1523/jneurosci.0291-17.2017.Peer-Reviewed Original ResearchMeSH KeywordsAcoustic StimulationAdultAnticipation, PsychologicalAttentionAuditory CortexAuditory PathwaysAuditory PerceptionFemaleHumansLong-Term PotentiationMaleSynaptic TransmissionConceptsMagnetic field amplitudeField amplitudeAuditory processing streamSynaptic gainHealthy human volunteersSustained effectCross-spectral densityDynamic causal modelingSlow modulationSynaptic efficacyNeural gain modulationSlow fluctuationsBrain activityModel-based parametersHuman volunteersAuditory cortexModulation of synaptic gainGain modulationGamma activityProcess streamsModulation of brain activityPredictability of stimuliInduced activationEffects of predictabilitySource-level analysis
2016
Temporal Expectations Guide Dynamic Prioritization in Visual Working Memory through Attenuated α Oscillations
van Ede F, Niklaus M, Nobre A. Temporal Expectations Guide Dynamic Prioritization in Visual Working Memory through Attenuated α Oscillations. Journal Of Neuroscience 2016, 37: 437-445. PMID: 28077721, PMCID: PMC5242399, DOI: 10.1523/jneurosci.2272-16.2016.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlpha RhythmAnticipation, PsychologicalFemaleHumansMaleMemory, Short-TermPhotic StimulationRandom AllocationTime FactorsVisual PerceptionYoung AdultConceptsVisual working memoryWorking memoryTemporal expectationsAttentional prioritizationNeural substratesBrain areasStudies of working memoryFlexible goal-directed behaviorMemory retrieval timeInvestigate working memoryWorking memory performanceGoal-directed behaviorEcologically valid contextInvestigated visual working memorySensory brain areasVisual brain areasMemory performanceLaboratory tasksNeuronal underpinningsMental representationsNeural mechanismsDelay intervalNeural implementationValid contextsPrecision judgments
2013
Reward Associations Magnify Memory-based Biases on Perception
Doallo S, Patai E, Nobre A. Reward Associations Magnify Memory-based Biases on Perception. Journal Of Cognitive Neuroscience 2013, 25: 245-257. PMID: 23066690, DOI: 10.1162/jocn_a_00314.Peer-Reviewed Original ResearchConceptsReward outcomesNeural processesEarly perceptual stageMemory-guided attentionEffect of spatial memoryLocations of relevant objectsContextual memoryPerceptual stageSpatial memoryBehavioral measuresBrain activityRecordings of brain activityRewardOptimal perceptionMemoryImpact perceptionsRelevant objectsTarget objectPerceptionBiasComplex scenesDiscriminationOutcomesSource of predictabilityComplex environments
2012
Temporal Expectation Improves the Quality of Sensory Information
Rohenkohl G, Cravo A, Wyart V, Nobre A. Temporal Expectation Improves the Quality of Sensory Information. Journal Of Neuroscience 2012, 32: 8424-8428. PMID: 22699922, PMCID: PMC4235252, DOI: 10.1523/jneurosci.0804-12.2012.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnticipation, PsychologicalDiscrimination, PsychologicalFemaleHumansMaleModels, PsychologicalPhotic StimulationReaction TimeTime FactorsVisual PerceptionConceptsTemporal expectationsQuality of sensory informationVisual targetModulate visual perceptionSensory informationVisual perceptionRhythmic temporal expectationRelevant sensory informationAction preparationPerceptual processingSensory evidenceAttentional focusOptimal information processingPsychophysical paradigmInformation processingOrientation discriminationPsychometric functionsVisual gratingsTemporal regularityReaction timeExternal eventsIrregular conditionsTemporal structureContrast sensitivitySignal strength
2011
Alpha Oscillations Related to Anticipatory Attention Follow Temporal Expectations
Rohenkohl G, Nobre A. Alpha Oscillations Related to Anticipatory Attention Follow Temporal Expectations. Journal Of Neuroscience 2011, 31: 14076-14084. PMID: 21976492, PMCID: PMC4235253, DOI: 10.1523/jneurosci.3387-11.2011.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlpha RhythmAnticipation, PsychologicalAttentionFemaleHumansMalePhotic StimulationPsychomotor PerformanceReaction TimeTime PerceptionYoung AdultConceptsTemporal expectationsAlpha-band activityTarget stimuliOscillatory alpha-band activityAlpha desynchronizationCortical excitabilityRegulate cortical excitabilityEvent-related potentialsRegulate excitabilityTask-relevant eventsOscillatory brain activityExcitationPerceptual discriminationOcclusion periodBrain activitySpatial attentionSpatial expectationsAlpha oscillationsEnhancement of processesTime courseBandOccluding bandAlpha bandVisual areasOscillationsIndexing the graded allocation of visuospatial attention using anticipatory alpha oscillations
Gould I, Rushworth M, Nobre A. Indexing the graded allocation of visuospatial attention using anticipatory alpha oscillations. Journal Of Neurophysiology 2011, 105: 1318-1326. PMID: 21228304, PMCID: PMC3074422, DOI: 10.1152/jn.00653.2010.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlpha RhythmAnticipation, PsychologicalAttentionBiological ClocksEvoked Potentials, VisualHumansMaleOccipital LobeParietal LobeSpace PerceptionConceptsAllocation of visuospatial attentionVisuospatial attentionAssociated with response preparationEvent-related potential measuresPredictive of behavioral performanceTime-frequency analysis of EEG dataSpatial certaintyAlpha oscillationsLateralization of alpha-band activityCue-target intervalProcessing of targetsTop-down controlAlpha-band activityAnalysis of EEG dataAttentional goalsBehavioral performanceResponse preparationOccipitoparietal cortexNeural mechanismsAlpha lateralizationAlpha modulationReaction timeBeta bandLateralizationEEG data