2019
Neural markers of category-based selective working memory in aging
Mok R, O'Donoghue M, Myers N, Drazich E, Nobre A. Neural markers of category-based selective working memory in aging. NeuroImage 2019, 194: 163-173. PMID: 30905834, PMCID: PMC6547047, DOI: 10.1016/j.neuroimage.2019.03.033.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAttentionFemaleHealthy AgingHumansMagnetic Resonance ImagingMaleMemory, Short-TermMiddle AgedPrefrontal CortexConceptsWorking memoryNetwork of brain regionsConsequence of selective attentionOlder adultsFunctional magnetic resonance imagingPsychophysiological interaction analysisCategory-sensitive areasRecognition-memory taskAnterior cingulate cortexNon-sensory corticesMeasures of attentionLevel of task performanceTop-down attentionGroup of older adultsNormal cognitive functionWM spanCognitive controlWM performancePrefrontal cortexMemory measuresCingulate cortexAttentional controlMemory processesNeural measuresAttended items
2018
Not All Predictions Are Equal: “What” and “When” Predictions Modulate Activity in Auditory Cortex through Different Mechanisms
Auksztulewicz R, Schwiedrzik C, Thesen T, Doyle W, Devinsky O, Nobre A, Schroeder C, Friston K, Melloni L. Not All Predictions Are Equal: “What” and “When” Predictions Modulate Activity in Auditory Cortex through Different Mechanisms. Journal Of Neuroscience 2018, 38: 8680-8693. PMID: 30143578, PMCID: PMC6170983, DOI: 10.1523/jneurosci.0369-18.2018.Peer-Reviewed Original ResearchConceptsNeural mechanismsNeural processesMotor areaSensory processingCortical activitySuperior temporal gyrusShort-term plasticityTiming of acoustic eventsAuditory areasMechanisms of predictionPrefrontal regionsPrefrontal areasTemporal gyrusBrain regionsManipulated predictionNeural responsesStimulus attributesStimulus featuresEncode predictionsParticipants' predictionsAdaptive behaviorEnvironmental regularitiesNeurophysiological mechanismsCortical hierarchyExperimental manipulation
2015
Modulation of hippocampal theta and hippocampal‐prefrontal cortex function by a schizophrenia risk gene
Cousijn H, Tunbridge E, Rolinski M, Wallis G, Colclough G, Woolrich M, Nobre A, Harrison P. Modulation of hippocampal theta and hippocampal‐prefrontal cortex function by a schizophrenia risk gene. Human Brain Mapping 2015, 36: 2387-2395. PMID: 25757652, PMCID: PMC4672713, DOI: 10.1002/hbm.22778.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBrain MappingGenetic Predisposition to DiseaseGenotypeHippocampusHomozygoteHumansKruppel-Like Transcription FactorsMagnetic Resonance ImagingMagnetoencephalographyNeural PathwaysPolymorphism, Single NucleotidePrefrontal CortexRisk FactorsSchizophreniaTheta RhythmYoung AdultConceptsFunctional magnetic resonance imagingHippocampal thetaPrefrontal cortexFunctional connectivityAssociated with functional connectivityHippocampal networkSuperior frontal gyrusSchizophrenia risk genesTheta-band oscillationsDual regression approachNetwork coactivationsZNF804A rs1344706Frontal gyrusZNF804A polymorphismsZNF804A geneBrain regionsBrain activityZNF804ABrain functionSchizophreniaHippocampalInvestigate coactivationOscillatory activityTheta bandMagnetoencephalography
2011
Top-down modulation: bridging selective attention and working memory
Gazzaley A, Nobre A. Top-down modulation: bridging selective attention and working memory. Trends In Cognitive Sciences 2011, 16: 129-135. PMID: 22209601, PMCID: PMC3510782, DOI: 10.1016/j.tics.2011.11.014.Peer-Reviewed Original ResearchConceptsTop-down modulationSource of top-down signalsMaintenance of relevant informationParietal control regionsInfluence working memoryHuman neurophysiological studiesEncoding of stimuliTop-down signalsWM taskMemory retrievalWorking memoryCognitive operationsNeural mechanismsSelective attentionCognitive resourcesReview recent evidenceStimulus-presentCore featuresSensory cortexNeurophysiological studiesConcurrent engagementMemoryRecent evidenceStimuliActivity modulation
2005
Components of Attentional Set-switching
Rushworth M, Passingham R, Nobre A. Components of Attentional Set-switching. Experimental Psychology 2005, 52: 83-98. PMID: 15850156, DOI: 10.1027/1618-3169.52.2.83.Peer-Reviewed Original ResearchConceptsEvent-related potentialsAttentional setTask switchingIntentional setSwitch cuesFrontal modulationNeural correlatesSet switchingEvent-related potentials time-lockedEvent-related potentials timeTask-switching paradigmResponse-related potentialsAssociated with modulationPairs of stimuliVisual stimulus dimensionsStay cuesStimulus dimensionsParietal electrodesSensory stimuliCuesScalp of human subjectsStimuliTaskSubjectsHuman subjects
2003
The posterior cingulate and medial prefrontal cortex mediate the anticipatory allocation of spatial attention
Small DM, Gitelman DR, Gregory MD, Nobre AC, Parrish TB, Mesulam M. The posterior cingulate and medial prefrontal cortex mediate the anticipatory allocation of spatial attention. NeuroImage 2003, 18: 633-641. PMID: 12667840, DOI: 10.1016/s1053-8119(02)00012-5.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexCue benefitPrefrontal cortexPosterior cingulateAttention-related areasNeutral cuesCentral cuesSpatial attentionSpatial expectancyFMRI scanningIrrelevant locationsMotivational valenceGreater activationParietal cortexBrain regionsCuesPeripheral targetsReaction timeCingulateCortexDistractibilityExpectancySignificant eventsAttentionValence
2001
Orienting attention to instants in time
Nobre A. Orienting attention to instants in time. Neuropsychologia 2001, 39: 1317-1328. PMID: 11566314, DOI: 10.1016/s0028-3932(01)00120-8.Peer-Reviewed Original ResearchConceptsAssociated with motor responsesFlexibility of attentional functionsAmplitude of event-related potentialsTemporal orientationEvent-related potentialsEnhanced behavioral performanceOptimization of behaviorVisual spatial attentionAttentional orientingBrain systemsAttentional functionsOrienting attentionBehavioral performanceBehavioral advantageNeural mechanismsMotor preparationStimulus attributesNeural systemsSpatial attentionMotor responseSensorimotor areasHuman brainBrainSpatial orientationSensorimotor
2000
Orienting attention in time: behavioural and neuroanatomical distinction between exogenous and endogenous shifts
Coull J, Frith C, Büchel C, Nobre A. Orienting attention in time: behavioural and neuroanatomical distinction between exogenous and endogenous shifts. Neuropsychologia 2000, 38: 808-819. PMID: 10689056, DOI: 10.1016/s0028-3932(99)00132-3.Peer-Reviewed Original ResearchConceptsInvalid trialsBrain areasEvent-related fMRI studyAssociated with attentional orientingLength of delayTemporal orienting of attentionCue-target delaysVisual extrastriate cortexCue-target intervalRight prefrontal cortexOrienting of attentionAllocation of attentionTrial validityNeuroanatomical distinctionOrbitofrontal cortexPrefrontal cortexCue-targetAttentional orientingFMRI studyOrienting attentionTrial-typesSpatial tasksAssociated with activationAttentional confoundsFoveal visual stimuli
1999
Orbitofrontal cortex is activated during breaches of expectation in tasks of visual attention
Nobre A, Coull J, Frith C, Mesulam M. Orbitofrontal cortex is activated during breaches of expectation in tasks of visual attention. Nature Neuroscience 1999, 2: 11-12. PMID: 10195173, DOI: 10.1038/4513.Peer-Reviewed Original ResearchMeSH KeywordsAdultAttentionCerebrovascular CirculationHumansMalePrefrontal CortexTomography, Emission-ComputedVisual PerceptionConceptsPrefrontal cortexTasks of visual attentionPositron emission tomographyVisual spatial orientingBreaches of expectationInformation processing limitationsOrbitofrontal cortexStimulus associationsBrain systemsNeural systemsVisual attentionCortexProcessing limitationsExecutive rolesTaskSpatial orientationSamenessStimuliAttentionResponse
1997
Functional localization of the system for visuospatial attention using positron emission tomography.
Nobre A, Sebestyen G, Gitelman D, Mesulam M, Frackowiak R, Frith C. Functional localization of the system for visuospatial attention using positron emission tomography. Brain 1997, 120: 515-533. PMID: 9126062, DOI: 10.1093/brain/120.3.515.Peer-Reviewed Original ResearchConceptsShifts of attentionVisuospatial attentionAttention taskNeural systemsRight anterior cingulate gyrusCovert shifts of attentionPatterns of neural activityRight posterior parietal cortexAnterior cingulate gyrusLateral premotor cortexPosterior parietal cortexIndividual-subject levelRegional functional specializationIntraparietal sulcusCingulate gyrusParietal cortexTarget stimuliAttention conditionCovert shiftsPremotor cortexPeripheral cuesCortical regionsSpatial attentionNeural activityBehavioral studies
1994
Functional magnetic resonance imaging of human prefrontal cortex activation during a spatial working memory task.
McCarthy G, Blamire AM, Puce A, Nobre AC, Bloch G, Hyder F, Goldman-Rakic P, Shulman RG. Functional magnetic resonance imaging of human prefrontal cortex activation during a spatial working memory task. Proceedings Of The National Academy Of Sciences Of The United States Of America 1994, 91: 8690-8694. PMID: 8078943, PMCID: PMC44672, DOI: 10.1073/pnas.91.18.8690.Peer-Reviewed Original ResearchMeSH KeywordsColor PerceptionFemaleHumansMagnetic Resonance ImagingMaleMemoryPrefrontal CortexSpace PerceptionConceptsMemory taskMiddle frontal gyrusHuman prefrontal cortexFrontal gyrusPrefrontal cortexMemory functionControl taskFunctional magnetic resonance imagingPrefrontal cortex activationSpatial memory processesArea 46Brodmann's area 46Task onsetHemisphere activationMemory processesCortex activationSubject's taskTarget eventNonhuman primatesTask completionCurrent stimulusStimuliTaskMagnetic resonance imagingGyrus