2016
Oxford Lithium Trial (OxLith) of the early affective, cognitive, neural and biochemical effects of lithium carbonate in bipolar disorder: study protocol for a randomised controlled trial
Saunders K, Cipriani A, Rendell J, Attenburrow M, Nelissen N, Bilderbeck A, Vasudevan S, Churchill G, Goodwin G, Nobre A, Harmer C, Harrison P, Geddes J. Oxford Lithium Trial (OxLith) of the early affective, cognitive, neural and biochemical effects of lithium carbonate in bipolar disorder: study protocol for a randomised controlled trial. Trials 2016, 17: 116. PMID: 26936776, PMCID: PMC4776410, DOI: 10.1186/s13063-016-1230-7.Peer-Reviewed Original ResearchMeSH KeywordsAdultAffectAntimanic AgentsBiomarkersBipolar DisorderBrainClinical ProtocolsCognitionDouble-Blind MethodEnglandFemaleGene Expression RegulationHumansLithium CarbonateMagnetic Resonance ImagingMagnetoencephalographyMaleNeuropsychological TestsProspective StudiesPsychiatric Status Rating ScalesResearch DesignTime FactorsTreatment OutcomeYoung AdultConceptsBipolar disorderLithium trialExperimental medicine modelEffects of lithium carbonateMulti-modal investigationsMood stabilisersMood instabilityPlacebo-controlled studyCognitive testsLithium treatmentLithium carbonateDouble-blindDisordersMoodCircadian effectsMedicine modelBiochemical effectsRandomised controlled trialsTherapeutic responseParticipantsEarly effectsSide effectsClinical useFMRIEffective drugs
2014
Guiding functional connectivity estimation by structural connectivity in MEG: an application to discrimination of conditions of mild cognitive impairment
Pineda-Pardo J, Bruña R, Woolrich M, Marcos A, Nobre A, Maestú F, Vidaurre D. Guiding functional connectivity estimation by structural connectivity in MEG: an application to discrimination of conditions of mild cognitive impairment. NeuroImage 2014, 101: 765-777. PMID: 25111472, PMCID: PMC4312351, DOI: 10.1016/j.neuroimage.2014.08.002.Peer-Reviewed Original ResearchConceptsGraphical lassoPrecision matrixAdaptive versionResting state MEG recordingsAnatomical connectionsL1 regularizationClassification accuracyFunctional connectivity estimatesLog-likelihoodResting-state connectivityAnatomical parcellationBrain connectivityMultiple-domain amnestic MCINetwork structureTime seriesConnectivity estimatesDeterministic tractographyNetworkStructural connectivityBeamformer source reconstructionFrequency bandClassificationSource reconstructionRepresentationState connectivity