2019
The Oxford study of Calcium channel Antagonism, Cognition, Mood instability and Sleep (OxCaMS): study protocol for a randomised controlled, experimental medicine study
Atkinson L, Colbourne L, Smith A, Harmer C, Nobre A, Rendell J, Jones H, Hinds C, Mould A, Tunbridge E, Cipriani A, Geddes J, Saunders K, Harrison P. The Oxford study of Calcium channel Antagonism, Cognition, Mood instability and Sleep (OxCaMS): study protocol for a randomised controlled, experimental medicine study. Trials 2019, 20: 120. PMID: 30755265, PMCID: PMC6373140, DOI: 10.1186/s13063-019-3175-0.Peer-Reviewed Original ResearchConceptsMood instabilityExperimental medicine studiesPsychiatric disordersPlacebo-controlled experimental medicine studyL-type calcium channelsAetiology of psychiatric disordersCalcium channel antagonismBipolar disorderHealthy young adultsMoodCognitionCalcium channel geneVoltage-gated calcium channel geneYoung adultsDouble-blindMedicine studiesDisordersAntagonist nicardipineCalcium channelsSleepCACNA1CChannel genesTreat hypertensionOxford studyTherapeutic potential
2016
Slow wave sleep and accelerated forgetting
Atherton K, Nobre A, Lazar A, Wulff K, Whittaker R, Dhawan V, Lazar Z, Zeman A, Butler C. Slow wave sleep and accelerated forgetting. Cortex 2016, 84: 80-89. PMID: 27710778, PMCID: PMC5084685, DOI: 10.1016/j.cortex.2016.08.013.Peer-Reviewed Original ResearchConceptsAccelerated long-term forgettingSlow wave sleepMemory benefitsAmount of slow wave sleepWord pair association taskLong-term forgettingBenefits of sleepDeclarative memoryAccelerated forgettingMemory consolidationAssociation taskMemory retentionBrain activityHealthy control groupHealthy participantsMemoryHealthy individualsElectrographic epileptiform activitySleepForgettingEpileptiform activityIndividualsSleep stagesControl groupHealthy people
2014
Sleep-dependent memory consolidation and accelerated forgetting
Atherton K, Nobre A, Zeman A, Butler C. Sleep-dependent memory consolidation and accelerated forgetting. Cortex 2014, 54: 92-105. PMID: 24657478, PMCID: PMC4007033, DOI: 10.1016/j.cortex.2014.02.009.Peer-Reviewed Original ResearchConceptsAccelerated long-term forgettingSleep-dependent memory consolidationTransient epileptic amnesiaMemory consolidationMemory retentionTEA patientsMemory consolidation processesDay of wakefulnessConsolidation of memoryLong-term forgettingNight of sleepRetention of informationMemory taskAccelerated forgettingMemory processesRetention intervalMemory impairmentCognitive performanceBehavioral assessmentSleep-dependentEpileptic amnesiaWake conditionsConsolidation processHealthy peopleMemory