Increased cerebral functional connectivity in ALS
Proudfoot M, Colclough G, Quinn A, Wuu J, Talbot K, Benatar M, Nobre A, Woolrich M, Turner M. Increased cerebral functional connectivity in ALS. Neurology 2018, 90: e1418-e1424. PMID: 29661904, PMCID: PMC5902786, DOI: 10.1212/wnl.0000000000005333.Peer-Reviewed Original ResearchConceptsAmyotrophic lateral sclerosisHealthy controlsMutation carrier groupPrimary lateral sclerosisLateral sclerosisClinical spectrumAmyotrophic lateral sclerosis pathologyPatient groupAsymptomatic carriersCerebral functional connectivityFunctional connectivityIncreased functional connectivityPosterior cingulate cortexPatientsMutations associated with amyotrophic lateral sclerosisResting-state magnetoencephalographyNeuronal oscillationsCingulate cortexCarrier groupCortical functionQuantitative markerNeuroprotective therapeuticsPresymptomatic periodSclerosisMarkers