2024
A Neural Decision Signal during Internal Sampling from Working Memory in Humans
van Ede F, Nobre A. A Neural Decision Signal during Internal Sampling from Working Memory in Humans. Journal Of Neuroscience 2024, 44: e1475232024. PMID: 38538144, PMCID: PMC11079964, DOI: 10.1523/jneurosci.1475-23.2024.Peer-Reviewed Original ResearchConceptsWorking memoryDomains of working memoryMemory-guided behaviorEvolving decision processesInternal visual representationsNeural evidenceParietal positivitySensory evidenceMental contentMemory contentPurposeful behaviorDecision signalsTime participantsMemorySensory informationInternational sampleMultiple contentsDecision processVisual representationPsychologyDecision-making frameworkNeuroscienceEvidenceBehaviorParticipantsShifting attention between perception and working memory
Gresch D, Boettcher S, van Ede F, Nobre A. Shifting attention between perception and working memory. Cognition 2024, 245: 105731. PMID: 38278040, DOI: 10.1016/j.cognition.2024.105731.Peer-Reviewed Original ResearchConceptsWorking memoryExperiment 1Working-memory taskShifts of attentionStay trialsAttentional orientingAttention domainEveryday cognitionAttention shiftsExperiment 2Shift trialsSpatial attentionAdaptive behaviorBaseline conditionsMemoryEveryday tasksSensory stimulationSensory signalsParticipantsTaskItemsPerceptionCognitionAttentionInternal domainTime for What? Dissociating Explicit Timing Tasks through Electrophysiological Signatures
Bueno F, Nobre A, Cravo A. Time for What? Dissociating Explicit Timing Tasks through Electrophysiological Signatures. ENeuro 2024, 11: eneuro.0351-23.2023. PMID: 38272676, PMCID: PMC10884563, DOI: 10.1523/eneuro.0351-23.2023.Peer-Reviewed Original ResearchConceptsExplicit timing tasksTime taskMultivariate pattern analysisReference stimulusNeural timing mechanismTask-dependent processingTiming mechanismNeural processesTask contextElectrophysiological signaturesExperimental blocksStimulus durationHuman participantsTask requirementsStimuliTaskPattern analysisParticipantsComparing intervalsElectroencephalogram
2022
New Therapeutics in Alzheimer’s Disease Longitudinal Cohort study (NTAD): study protocol
Lanskey J, Kocagoncu E, Quinn A, Cheng Y, Karadag M, Pitt J, Lowe S, Perkinton M, Raymont V, Singh K, Woolrich M, Nobre A, Henson R, Rowe J. New Therapeutics in Alzheimer’s Disease Longitudinal Cohort study (NTAD): study protocol. BMJ Open 2022, 12: e055135. PMID: 36521898, PMCID: PMC9756184, DOI: 10.1136/bmjopen-2021-055135.Peer-Reviewed Original ResearchConceptsMild cognitive impairmentEarly-stage Alzheimer's diseaseCognitive impairmentPeer-reviewed scientific journalsLongitudinal cohort studyResearch Ethics CommitteeAlzheimer's diseaseAmyloid-positive mild cognitive impairmentAlzheimer's disease studyConference presentationsCohort studyMeasures of diseaseCognitive AssessmentDisease StudyStudy protocolPrimary analysisEthics CommitteeLongitudinal changesParticipantsCognitive changesWebsite publicationClinical trial durationNew therapeuticsEast of England-Cambridge Central Research Ethics CommitteeProgression of Alzheimer's diseaseRight Place, Right Time: Spatiotemporal Predictions Guide Attention in Dynamic Visual Search
Boettcher S, Shalev N, Wolfe J, Nobre A. Right Place, Right Time: Spatiotemporal Predictions Guide Attention in Dynamic Visual Search. Journal Of Experimental Psychology General 2022, 151: 348-362. PMID: 34843369, PMCID: PMC8920297, DOI: 10.1037/xge0000901.Peer-Reviewed Original ResearchConceptsVisual searchLong-term representationsEye-movement recordingsLong-term learningExperiment 4Priming effectExperiment 1Experiment 2Spatiotemporal regularityGuides attentionParticipants' performanceElements of human behaviorReal-life searchStatic displaysHuman behaviorParticipantsDynamic environmentLaboratory settingTaskDistractorsExtended processSpatiotemporal predictionTemporal dimensionRegularization
2020
Functional biases in attentional templates from associative memory
Boettcher S, van Ede F, Nobre A. Functional biases in attentional templates from associative memory. Journal Of Vision 2020, 20: 7-7. PMID: 33296459, PMCID: PMC7729124, DOI: 10.1167/jov.20.13.7.Peer-Reviewed Original ResearchConceptsParticipants learned associationsCurrent task demandsLong-term memoryAttentional templatesTask demandsTask performanceBehavioral responsesExperimental blocksAssociative memoryMemoryLuresFunctional biasParticipantsContext-dependentEncode informationNonmatchEveryday lifeAssociationFeature dimensionsCombination of colorColored gratingsTaskRetrievalPerceptionHypothesisWhen Natural Behavior Engages Working Memory
Draschkow D, Kallmayer M, Nobre A. When Natural Behavior Engages Working Memory. Current Biology 2020, 31: 869-874.e5. PMID: 33278355, PMCID: PMC7902904, DOI: 10.1016/j.cub.2020.11.013.Peer-Reviewed Original ResearchConceptsLaboratory tasksProperties of WMWM representationsWorking memoryIncreased locomotionParticipants' avoidanceEncoding durationCognitive processesEcological validityImmersive taskCognitive systemExperimental rigorGathering informationTaskTask completionMemorySensitive measureVR approachExternal informationTemporary storageParticipantsSample informationBehaviorLocomotive demandsInformation
2019
Dissecting beta-state changes during timed movement preparation in Parkinson’s disease
Heideman S, Quinn A, Woolrich M, van Ede F, Nobre A. Dissecting beta-state changes during timed movement preparation in Parkinson’s disease. Progress In Neurobiology 2019, 184: 101731. PMID: 31778771, PMCID: PMC6977086, DOI: 10.1016/j.pneurobio.2019.101731.Peer-Reviewed Original ResearchWhole-brain white matter organization, intelligence, and educational attainment
Bathelt J, Scerif G, Nobre A, Astle D. Whole-brain white matter organization, intelligence, and educational attainment. Trends In Neuroscience And Education 2019, 15: 38-47. PMID: 31176470, PMCID: PMC6556839, DOI: 10.1016/j.tine.2019.02.004.Peer-Reviewed Original ResearchConceptsNeural correlates of intelligenceGeneral cognitive abilityCorrelates of intelligenceAssociated with intelligenceTypically-developing childrenBrain network propertiesVoxel-wise analysisAssociated with educational attainmentNeural correlatesCognitive abilitiesBrain regionsConnectome organizationDevelopmental theoryEducational attainmentChildhood focusChildhoodBrainIntelligenceNetwork propertiesEducational abilitiesAttainmentAbilityConnectomeRelationshipParticipants
2018
Early Behavioural Facilitation by Temporal Expectations in Complex Visual-motor Sequences
Heideman S, van Ede F, Nobre A. Early Behavioural Facilitation by Temporal Expectations in Complex Visual-motor Sequences. Neuroscience 2018, 389: 74-84. PMID: 29802816, DOI: 10.1016/j.neuroscience.2018.05.014.Peer-Reviewed Original ResearchConceptsVisual-motor sequencesTemporal expectationsTemporal orientationReaction time differencesSpatial-temporal sequenceBehavioral facilitationBehavioral benefitsIncidental learningInter-element intervalsFacilitatory influenceBehavioral responsesIncidental acquisitionTemporal cuesLate blockMultiple presentationsSequential structureSessionsTaskCentral hypothesisParticipantsModified versionCuesSequence structureExpectationsLong intervals
2017
Competitive interactions affect working memory performance for both simultaneous and sequential stimulus presentation
Ahmad J, Swan G, Bowman H, Wyble B, Nobre A, Shapiro K, McNab F. Competitive interactions affect working memory performance for both simultaneous and sequential stimulus presentation. Scientific Reports 2017, 7: 4785. PMID: 28684800, PMCID: PMC5500476, DOI: 10.1038/s41598-017-05011-x.Peer-Reviewed Original ResearchConceptsWM precisionSequential presentationMeasures of working memoryWorking memory performanceSequential stimulus presentationProximity of stimuliMemory performanceBOLD responseStimulus presentationSimultaneous presentationVisual stimuliNeural firingStimuliWMItemsParticipantsBOLDMemoryTaskPresentationSequential competition
2016
Early behavioural facilitation by temporal expectations in complex visual-motor sequences
Heideman S, van Ede F, Nobre A. Early behavioural facilitation by temporal expectations in complex visual-motor sequences. Journal Of Physiology-Paris 2016, 110: 487-496. PMID: 28323028, PMCID: PMC5742633, DOI: 10.1016/j.jphysparis.2017.03.003.Peer-Reviewed Original ResearchConceptsVisual-motor sequencesTemporal expectationsTemporal orientationReaction time differencesSpatial-temporal sequenceBehavioral facilitationBehavioral benefitsIncidental learningInter-element intervalsFacilitatory influenceBehavioral responsesIncidental acquisitionTemporal cuesLate blockMultiple presentationsSequential structureSessionsTaskCentral hypothesisParticipantsModified versionDaily lifeCuesSequence structureExpectationsOxford Lithium Trial (OxLith) of the early affective, cognitive, neural and biochemical effects of lithium carbonate in bipolar disorder: study protocol for a randomised controlled trial
Saunders K, Cipriani A, Rendell J, Attenburrow M, Nelissen N, Bilderbeck A, Vasudevan S, Churchill G, Goodwin G, Nobre A, Harmer C, Harrison P, Geddes J. Oxford Lithium Trial (OxLith) of the early affective, cognitive, neural and biochemical effects of lithium carbonate in bipolar disorder: study protocol for a randomised controlled trial. Trials 2016, 17: 116. PMID: 26936776, PMCID: PMC4776410, DOI: 10.1186/s13063-016-1230-7.Peer-Reviewed Original ResearchMeSH KeywordsAdultAffectAntimanic AgentsBiomarkersBipolar DisorderBrainClinical ProtocolsCognitionDouble-Blind MethodEnglandFemaleGene Expression RegulationHumansLithium CarbonateMagnetic Resonance ImagingMagnetoencephalographyMaleNeuropsychological TestsProspective StudiesPsychiatric Status Rating ScalesResearch DesignTime FactorsTreatment OutcomeYoung AdultConceptsBipolar disorderLithium trialExperimental medicine modelEffects of lithium carbonateMulti-modal investigationsMood stabilisersMood instabilityPlacebo-controlled studyCognitive testsLithium treatmentLithium carbonateDouble-blindDisordersMoodCircadian effectsMedicine modelBiochemical effectsRandomised controlled trialsTherapeutic responseParticipantsEarly effectsSide effectsClinical useFMRIEffective drugs
2014
Failure to perceive clinical events: An under-recognised source of error
Greig P, Higham H, Nobre A. Failure to perceive clinical events: An under-recognised source of error. Resuscitation 2014, 85: 952-956. PMID: 24746782, DOI: 10.1016/j.resuscitation.2014.03.316.Peer-Reviewed Original ResearchConceptsSimulated cardiac arrestAssociated with increased likelihoodAdult resuscitationPerceptual errorsPatient outcomesClinically significant eventsCardiac arrestFree textChange-eventsOxygen malfunctionAttentional focusPsychological literatureClinical eventsAdverse eventsCognitive workloadSituational awarenessExpertisePracticeError introductionVideoParticipantsSignificant eventsCliniciansPerceptual failuresResuscitation
2013
Distinct neural mechanisms of individual and developmental differences in VSTM capacity
Astle D, Harvey H, Stokes M, Mohseni H, Nobre A, Scerif G. Distinct neural mechanisms of individual and developmental differences in VSTM capacity. Developmental Psychobiology 2013, 56: 601-610. PMID: 23775219, DOI: 10.1002/dev.21126.Peer-Reviewed Original ResearchAttention Restores Discrete Items to Visual Short-Term Memory
Murray A, Nobre A, Clark I, Cravo A, Stokes M. Attention Restores Discrete Items to Visual Short-Term Memory. Psychological Science 2013, 24: 550-556. PMID: 23436786, PMCID: PMC4138001, DOI: 10.1177/0956797612457782.Peer-Reviewed Original Research
2012
Power corrupts co-operation: cognitive and motivational effects in a double EEG paradigm
Kanso R, Hewstone M, Hawkins E, Waszczuk M, Nobre A. Power corrupts co-operation: cognitive and motivational effects in a double EEG paradigm. Social Cognitive And Affective Neuroscience 2012, 9: 218-224. PMID: 23160813, PMCID: PMC3907926, DOI: 10.1093/scan/nss122.Peer-Reviewed Original ResearchConceptsEffects of interpersonal powerEvent-related potential analysisExpectation of rewardPairs of participantsBehavioral accuracyAttention taskMonetary rewardsMotivational effectsEEG paradigmInterpersonal powerMotivational resourcesSubjective magnitudesRewardNeutral groupConflict detectionMonetary lossesParticipantsParadigmCo-operative performanceLevel of controlTaskSubordinatesLacking Control over the Trade-Off between Quality and Quantity in Visual Short-Term Memory
Murray A, Nobre A, Astle D, Stokes M. Lacking Control over the Trade-Off between Quality and Quantity in Visual Short-Term Memory. PLOS ONE 2012, 7: e41223. PMID: 22905099, PMCID: PMC3414487, DOI: 10.1371/journal.pone.0041223.Peer-Reviewed Original ResearchConceptsVisual short-term memoryShort-term memoryMemory-based judgmentsStimulus-driven factorsTop-down controlPrecision of itemsMnemonic demandsExperiment 4Experiment 3Task demandsQuality of itemsItemsMemoryStrategic trade-offsContextual informationParticipantsLack controlJudgmentTaskMotivationTrade-offs
2011
Behavioural Dissociation between Exogenous and Endogenous Temporal Orienting of Attention
Rohenkohl G, Coull J, Nobre A. Behavioural Dissociation between Exogenous and Endogenous Temporal Orienting of Attention. PLOS ONE 2011, 6: e14620. PMID: 21297968, PMCID: PMC3030556, DOI: 10.1371/journal.pone.0014620.Peer-Reviewed Original ResearchConceptsSymbolic cuesTemporal orientationEffect of temporal orientationTemporal orienting of attentionSpeeded reaction timesStrategic controlOrienting of attentionNeutral trialsBehavioral dissociationCueing effectsEndogenous orientingPerceptual discriminationTemporal expectationsIntrinsic temporal structureSpatial attentionOccluding bandCuesRhythmic cuesTask designReaction timeTemporal structureMoving stimuliPredictive natureTaskParticipants
2010
Subliminally Presented and Stored Objects Capture Spatial Attention
Astle D, Nobre A, Scerif G. Subliminally Presented and Stored Objects Capture Spatial Attention. Journal Of Neuroscience 2010, 30: 3567-3571. PMID: 20219990, PMCID: PMC6632246, DOI: 10.1523/jneurosci.5701-09.2010.Peer-Reviewed Original Research