Altered cortical beta‐band oscillations reflect motor system degeneration in amyotrophic lateral sclerosis
Proudfoot M, Rohenkohl G, Quinn A, Colclough G, Wuu J, Talbot K, Woolrich M, Benatar M, Nobre A, Turner M. Altered cortical beta‐band oscillations reflect motor system degeneration in amyotrophic lateral sclerosis. Human Brain Mapping 2016, 38: 237-254. PMID: 27623516, PMCID: PMC5215611, DOI: 10.1002/hbm.23357.Peer-Reviewed Original ResearchConceptsPrimary lateral sclerosisAmyotrophic lateral sclerosisSensitive marker of disease activityPLS groupMotor cortex of ALS patientsBeta-band oscillationsMarkers of disease activityDevelopment of overt symptomsHealthy control groupALS spectrumAmyotrophic lateral sclerosis patientsAsymptomatic mutation carriersDiffusion tensor imaging studiesBeta desynchronizationSymptomatic patientsLateral sclerosisDisease activityMutation carriersGene mutationsCortical hyperexcitabilityAsymptomatic carriersSensitive markerNeuroprotective strategiesImaging studiesCortical dysfunctionChanges in cortical β-oscillation dynamics across the clinical spectrum of motor neuron disease
Proudfoot M, Rohenkohl G, Gould I, Wuu J, Andersen P, Talbot K, Woolrich M, Benatar M, Nobre A, Turner M. Changes in cortical β-oscillation dynamics across the clinical spectrum of motor neuron disease. The Lancet 2016, 387: s84. DOI: 10.1016/s0140-6736(16)00471-2.Peer-Reviewed Original ResearchAsymptomatic mutation carriersMutation carriersMotor neuron diseaseRelative to controlsAmyotrophic lateral sclerosisDevelopment of overt symptomsPrimary lateral sclerosisSymptomatic patientsLateral sclerosisClinical spectrumMotor cortexContralateral motor cortexHealthy controlsPatientsCortical dysfunctionOvert symptomsBiomarker discoveryGenetic riskNeuron diseaseMEG analysisInhibition trialsSclerosisMEG dataPathologyTrials