2019
Dynamic sustained attention markers differentiate atypical development: The case of Williams syndrome and Down's syndrome
Shalev N, Steele A, Nobre A, Karmiloff-Smith A, Cornish K, Scerif G. Dynamic sustained attention markers differentiate atypical development: The case of Williams syndrome and Down's syndrome. Neuropsychologia 2019, 132: 107148. PMID: 31323245, PMCID: PMC6891877, DOI: 10.1016/j.neuropsychologia.2019.107148.Peer-Reviewed Original ResearchConceptsSustained attentionWilliams syndromeDown syndromeContinuous performance taskImpaired sustained attentionAttention deficit symptomsMeasure sustained attentionSpecificity to changesAtypical developmentDeficit symptomsBehavioral disordersPerformance tasksAttention markerPoor functional outcomeCase of Williams syndromePoor performanceInvestigate similaritiesChildrenTaskAttentionDisordersFunctional outcomesDownElements of performanceSymptomsThe Oxford study of Calcium channel Antagonism, Cognition, Mood instability and Sleep (OxCaMS): study protocol for a randomised controlled, experimental medicine study
Atkinson L, Colbourne L, Smith A, Harmer C, Nobre A, Rendell J, Jones H, Hinds C, Mould A, Tunbridge E, Cipriani A, Geddes J, Saunders K, Harrison P. The Oxford study of Calcium channel Antagonism, Cognition, Mood instability and Sleep (OxCaMS): study protocol for a randomised controlled, experimental medicine study. Trials 2019, 20: 120. PMID: 30755265, PMCID: PMC6373140, DOI: 10.1186/s13063-019-3175-0.Peer-Reviewed Original ResearchConceptsMood instabilityExperimental medicine studiesPsychiatric disordersPlacebo-controlled experimental medicine studyL-type calcium channelsAetiology of psychiatric disordersCalcium channel antagonismBipolar disorderHealthy young adultsMoodCognitionCalcium channel geneVoltage-gated calcium channel geneYoung adultsDouble-blindMedicine studiesDisordersAntagonist nicardipineCalcium channelsSleepCACNA1CChannel genesTreat hypertensionOxford studyTherapeutic potential
2017
Anticipated moments: temporal structure in attention
Nobre A, van Ede F. Anticipated moments: temporal structure in attention. Nature Reviews Neuroscience 2017, 19: 34-48. PMID: 29213134, DOI: 10.1038/nrn.2017.141.Peer-Reviewed Original ResearchConceptsTemporal expectationsObject-based attentionDomains of perceptionFeature-based expectationRelevant sensory inputAttentional biasCue associationsCognitive domainsNeural mechanismsNeural responsesCognitive disordersSynchrony of neuronal activityTemporal structureNeuronal activityTemporal attentionSensory inputFeature-basedPointsAttentionRelevant momentsAttentionPerceptionExpectationsDisordersMagnetoencephalography as a Tool in Psychiatric Research: Current Status and Perspective
Uhlhaas P, Liddle P, Linden D, Nobre A, Singh K, Gross J. Magnetoencephalography as a Tool in Psychiatric Research: Current Status and Perspective. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2017, 2: 235-244. PMID: 28424797, PMCID: PMC5387180, DOI: 10.1016/j.bpsc.2017.01.005.Peer-Reviewed Original ResearchPsychiatric researchAberrant rhythmic activityAbnormal brain dynamicsAutism spectrum disorderNeurobiological mechanismsPsychiatric conditionsCircuit dysfunctionNeuropsychiatric disordersNeuropsychiatric conditionsSpectrum disorderApplication of magnetoencephalographyNeural oscillationsBrain dynamicsMagnetoencephalographyNeuronal eventsPreclinical researchDisordersMEG signalsMillisecond resolutionDevelopment of biomarkersSchizophreniaPathophysiological mechanismsPsychiatricAutismTranslational research
2016
Oxford Lithium Trial (OxLith) of the early affective, cognitive, neural and biochemical effects of lithium carbonate in bipolar disorder: study protocol for a randomised controlled trial
Saunders K, Cipriani A, Rendell J, Attenburrow M, Nelissen N, Bilderbeck A, Vasudevan S, Churchill G, Goodwin G, Nobre A, Harmer C, Harrison P, Geddes J. Oxford Lithium Trial (OxLith) of the early affective, cognitive, neural and biochemical effects of lithium carbonate in bipolar disorder: study protocol for a randomised controlled trial. Trials 2016, 17: 116. PMID: 26936776, PMCID: PMC4776410, DOI: 10.1186/s13063-016-1230-7.Peer-Reviewed Original ResearchMeSH KeywordsAdultAffectAntimanic AgentsBiomarkersBipolar DisorderBrainClinical ProtocolsCognitionDouble-Blind MethodEnglandFemaleGene Expression RegulationHumansLithium CarbonateMagnetic Resonance ImagingMagnetoencephalographyMaleNeuropsychological TestsProspective StudiesPsychiatric Status Rating ScalesResearch DesignTime FactorsTreatment OutcomeYoung AdultConceptsBipolar disorderLithium trialExperimental medicine modelEffects of lithium carbonateMulti-modal investigationsMood stabilisersMood instabilityPlacebo-controlled studyCognitive testsLithium treatmentLithium carbonateDouble-blindDisordersMoodCircadian effectsMedicine modelBiochemical effectsRandomised controlled trialsTherapeutic responseParticipantsEarly effectsSide effectsClinical useFMRIEffective drugsInnovative approaches to bipolar disorder and its treatment
Harrison P, Cipriani A, Harmer C, Nobre A, Saunders K, Goodwin G, Geddes J. Innovative approaches to bipolar disorder and its treatment. Annals Of The New York Academy Of Sciences 2016, 1366: 76-89. PMID: 27111134, PMCID: PMC4850752, DOI: 10.1111/nyas.13048.Peer-Reviewed Original ResearchConceptsBipolar disorderRelevant to bipolar disorderIndicators of target engagementMood stabilizersMood instabilityPsychiatric disordersDisorder pathophysiologyCalcium channel geneDrug effectsDisordersPharmacological interventionsTarget engagementTherapeutic responseClinical profileClinical episodesClinical phenotypeChannel genesNew treatmentsStem cellsKey pathwaysIncreasing evidenceMoodTreatmentPhenotypeExperimental medicine