The cortical neurophysiological signature of amyotrophic lateral sclerosis
Trubshaw M, Gohil C, Yoganathan K, Kohl O, Edmond E, Proudfoot M, Thompson A, Talbot K, Stagg C, Nobre A, Woolrich M, Turner M. The cortical neurophysiological signature of amyotrophic lateral sclerosis. Brain Communications 2024, 6: fcae164. PMID: 38779353, PMCID: PMC11109820, DOI: 10.1093/braincomms/fcae164.Peer-Reviewed Original ResearchAmyotrophic lateral sclerosisIncreasing disability scoreLateral sclerosisIncreased disabilityHealthy age-matched controlsIncreased muscle weaknessAge-matched controlsProgressive loss of motor functionAmplitude envelope correlationGamma-band powerHigh-gamma band powerLoss of motor functionDisease-causing genetic variantsPharmacodynamic biomarkersPredictive markerBand powerDisability scoresHigh-gamma frequency bandPaired-pulse transcranial magnetic stimulationAsymptomatic carriersEyes-open stateDiagnostic valueMuscle weaknessCortical betaGamma power