Junghee Jenny Shin, MD, PhD
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Assistant ProfessorCards
About
Research
Publications
2024
The Next Frontier: Defining and Optimizing Treatments for Patients with T2 Low Asthma
Zidan E, Wilson G, Shin J, Chupp G. The Next Frontier: Defining and Optimizing Treatments for Patients with T2 Low Asthma. Annals Of Allergy Asthma & Immunology 2024 PMID: 39414022, DOI: 10.1016/j.anai.2024.10.013.Peer-Reviewed Original ResearchIL-1 receptor 1 signaling shapes the development of viral antigen-specific CD4+ T cell responses following COVID-19 mRNA vaccination
Park H, Shin M, Shin J, Kim H, Kang B, Par-Young J, Unlu S, Afinogenova Y, Catanzaro J, Young J, Kim M, Lee S, Jeon S, You S, Racke M, Bucala R, Kang I. IL-1 receptor 1 signaling shapes the development of viral antigen-specific CD4+ T cell responses following COVID-19 mRNA vaccination. EBioMedicine 2024, 103: 105114. PMID: 38640835, PMCID: PMC11041015, DOI: 10.1016/j.ebiom.2024.105114.Peer-Reviewed Original ResearchConceptsCD4<sup>+</sup> T cellsCOVID-19 mRNA vaccinesAntigen-specific CD4<sup>+</sup> T cell responsesT cell responsesPrimary antibody deficiencyCD4<sup>+</sup> T cell responsesT cellsIL-1R1MRNA vaccinesIL-1IgG antibodiesAntigen-specific CD4<sup>+</sup> T cellsCD4+ T cell responsesLevels of IL-1R1Human CD4<sup>+</sup> T cellsIL-1 receptor 1Healthy individualsDose of COVID-19 mRNA vaccineAntigen-specific CD4IL-1R1 expressionT cell immunityRepetitive antigenic stimulationCytokines interleukin (IL)-1Immune response to virusesExpression of IL-1R1COVID-19 Vaccination in Patients with Inborn Errors of Immunity Reduces Hospitalization and Critical Care Needs Related to COVID-19: a USIDNET Report
McDonnell J, Cousins K, Younger M, Lane A, Abolhassani H, Abraham R, Al-Tamemi S, Aldave-Becerra J, Al-Faris E, Alfaro-Murillo A, AlKhater S, Alsaati N, Doss A, Anderson M, Angarola E, Ariue B, Arnold D, Assa’ad A, Aytekin C, Bank M, Bergerson J, Bleesing J, Boesing J, Bouso C, Brodszki N, Cabanillas D, Cady C, Callahan M, Caorsi R, Carbone J, Carrabba M, Castagnoli R, Catanzaro J, Chan S, Chandra S, Chapdelaine H, Chavoshzadeh Z, Chong H, Connors L, Consonni F, Correa-Jimenez O, Cunningham-Rundles C, D’Astous-Gauthier K, Delmonte O, Demirdag Y, Deshpande D, Diaz-Cabrera N, Dimitriades V, El-Owaidy R, ElGhazali G, Al-Hammadi S, Fabio G, Faure A, Feng J, Fernandez J, Fill L, Franco G, Frenck R, Fuleihan R, Giardino G, Galant-Swafford J, Gambineri E, Garabedian E, Geerlinks A, Goudouris E, Grecco O, Pan-Hammarström Q, Khani H, Hammarström L, Hartog N, Heimall J, Hernandez-Molina G, Horner C, Hostoffer R, Hristova N, Hsiao K, Ivankovich-Escoto G, Jaber F, Jalil M, Jamee M, Jean T, Jeong S, Jhaveri D, Jordan M, Joshi A, Kalkat A, Kanarek H, Kellner E, Khojah A, Khoury R, Kokron C, Kumar A, Lecerf K, Lehman H, Leiding J, Lesmana H, Lim X, Lopes J, López A, Tarquini L, Lundgren I, Magnusson J, Marinho A, Marseglia G, Martone G, Mechtler A, Mendonca L, Milner J, Mustillo P, Naderi A, Naviglio S, Nell J, Niebur H, Notarangelo L, Oleastro M, Ortega-López M, Patel N, Petrovic G, Pignata C, Porras O, Prince B, Puck J, Qamar N, Rabusin M, Raje N, Regairaz L, Risma K, Ristagno E, Routes J, Roxo-Junior P, Salemi N, Scalchunes C, Schuval S, Seneviratne S, Shankar A, Sherkat R, Shin J, Siddiqi A, Signa S, Sobh A, Lima F, Stenehjem K, Tam J, Tang M, Barros M, Verbsky J, Vergadi E, Voelker D, Volpi S, Wall L, Wang C, Williams K, Wu E, Wu S, Zhou J, Cook A, Sullivan K, Marsh R. COVID-19 Vaccination in Patients with Inborn Errors of Immunity Reduces Hospitalization and Critical Care Needs Related to COVID-19: a USIDNET Report. Journal Of Clinical Immunology 2024, 44: 86. PMID: 38578389, PMCID: PMC10997719, DOI: 10.1007/s10875-023-01613-5.Peer-Reviewed Original ResearchConceptsInborn errors of immunityCOVID-19 vaccineICU admissionInborn errors of immunity patientsInborn errorsUS Immunodeficiency NetworkErrors of immunityVaccination prior to infectionLogistic regression analysisVaccine safetyAntibody deficiencyRates of hospitalizationCOVID-19 severitySymptomatic anemiaOdds of hospitalizationCOVID-19 infectionRegistry databaseMRNA-basedCOVID-19 vaccine safetyPatientsOutpatient clinicEmergency room careICU careICUVaccine
2023
Modulating IL-1β and its receptors shapes spike-specific CD4 +T cell responses to mRNA vaccination
Park H, Shin M, Shin J, Kim H, Kang B, Par-Young J, Unlu S, Afinogenova Y, Catanzaro J, Young J, Kim M, Lee S, You S, Racke M, Bucala R, Kang I. Modulating IL-1β and its receptors shapes spike-specific CD4 +T cell responses to mRNA vaccination. The Journal Of Immunology 2023, 210: 159.20-159.20. DOI: 10.4049/jimmunol.210.supp.159.20.Peer-Reviewed Original ResearchCOVID-19 mRNA vaccinesT cellsIL-1βIL-1R2MRNA vaccinesIL-1 receptor 1IL-1R1 expressionIL-1R2 expressionSpike-specific CD4Vaccine-induced CD4T cell immunityT cell responsesSpecific antibody productionMRNA vaccinationCell immunityDurable immunityIL-1R1IL-1BCD4Healthy individualsQuest DiagnosticsAntibody productionCell responsesReceptor 1Receptor system
2022
Effect of Androgen–Androgen Receptor Directed Therapy on COVID-19 Outcome in Prostate Cancer Patients
Ünlü S, Shin J, Par-Young J, Simonov M, Vinetz J, Petrylak D, Kang I, Kim J. Effect of Androgen–Androgen Receptor Directed Therapy on COVID-19 Outcome in Prostate Cancer Patients. Cancer Investigation 2022, 41: 77-83. PMID: 36373994, DOI: 10.1080/07357907.2022.2139839.Peer-Reviewed Original ResearchConceptsProstate cancer patientsCOVID-19 outcomesCancer patientsPoor COVID-19 outcomesAndrogen-androgen receptorExpression of TMPRSS2COVID-19 infectionSARS-CoV-2Directed therapyMean hospitalizationPCa patientsHospitalization ratesPCa casesRetrospective analysisOutcome differencesPatientsDefinitive conclusionsStatistical significanceData generate hypothesesHospitalizationTherapyTMPRSS2Cellular entryOutcomesARDTMIF is a common genetic determinant of COVID-19 symptomatic infection and severity
Shin JJ, Fan W, Par-Young J, Piecychna M, Leng L, Israni-Winger K, Qing H, Gu J, Zhao H, Schulz WL, Unlu S, Kuster J, Young G, Liu J, Ko AI, Garcia A, Sauler M, Wisnewski AV, Young L, Orduña A, Wang A, Klementina O, Garcia AB, Hegyi P, Armstrong ME, Mitchell P, Ordiz DB, Garami A, Kang I, Bucala R. MIF is a common genetic determinant of COVID-19 symptomatic infection and severity. QJM 2022, 116: 205-212. PMID: 36222594, PMCID: PMC9620729, DOI: 10.1093/qjmed/hcac234.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorLow-expression MIF alleleCOVID-19 infectionMIF allelesCATT7 alleleHealthy controlsCOVID-19Serum macrophage migration inhibitory factorSymptomatic SARS-CoV-2 infectionHigher serum MIF levelsHigh-expression MIF allelesRetrospective case-control studySARS-CoV-2 infectionFunctional polymorphismsAvailable clinical characteristicsMultinational retrospective studySerum MIF levelsUninfected healthy controlsSymptomatic COVID-19Tertiary medical centerHealthy control subjectsCase-control studyMigration inhibitory factorCoronavirus disease 2019Common functional polymorphismsDefining Clinical and Immunological Predictors of Poor Immune Responses to COVID-19 mRNA Vaccines in Patients with Primary Antibody Deficiency
Shin JJ, Par-Young J, Unlu S, McNamara A, Park HJ, Shin MS, Gee RJ, Doyle H, Afinogenova Y, Zidan E, Kwah J, Russo A, Mamula M, Hsu FI, Catanzaro J, Racke M, Bucala R, Wilen C, Kang I. Defining Clinical and Immunological Predictors of Poor Immune Responses to COVID-19 mRNA Vaccines in Patients with Primary Antibody Deficiency. Journal Of Clinical Immunology 2022, 42: 1137-1150. PMID: 35713752, PMCID: PMC9203263, DOI: 10.1007/s10875-022-01296-4.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, ViralCD8-Positive T-LymphocytesCommon Variable ImmunodeficiencyCOVID-19COVID-19 VaccinesHumansImmunity, CellularImmunoglobulin AImmunoglobulin GMRNA VaccinesPrimary Immunodeficiency DiseasesRNA, MessengerSARS-CoV-2Spike Glycoprotein, CoronavirusVaccinationVaccinesVaccines, SyntheticConceptsCommon variable immune deficiencyT cellsImmune responseIgG responsesCVID patientsMRNA vaccinesB cellsCoronavirus disease 2019 (COVID-19) mRNA vaccinesCOVID-19 mRNA vaccinesBaseline immune profileHistory of autoimmunityPrimary antibody deficiencyT cell responsesCellular immune responsesPoor immune responseVariable immune deficiencyMemory B cellsSARS-CoV-2 spike proteinBaseline IgGCVID diagnosisEM CD8Immunological predictorsPAD cohortSpecific CD4Immune profileEffect of androgen receptor directed therapy in prostate cancer patients with COVID-19.
Unlu S, Shin J, Par-Young J, Vinetz J, Petrylak D, Kang I, Kim J. Effect of androgen receptor directed therapy in prostate cancer patients with COVID-19. Journal Of Clinical Oncology 2022, 40: 161-161. DOI: 10.1200/jco.2022.40.6_suppl.161.Peer-Reviewed Original ResearchProstate cancerPCa patientsAndrogen receptorCOVID-19Mortality rateYale New Haven Health SystemProtective rolePrevalence of PCaRate of hospitalRetrospective chart reviewExpression of TMPRSS2Rate of hospitalizationProstate cancer patientsAndrogen receptor antagonistProstate cancer casesSARS-CoV-2Institutional review boardDirected therapyChart reviewClinical characteristicsGnRH agonistHormone therapyGnRH antagonistHome medicationsClinical outcomesPeripheral Blood Cell Counts Predict Distinct Endoscopic Phenotypes In Eosinophilic Esophagitis
Shin J, Kaman K, Anthonypillai J, Soffer G, Kang I. Peripheral Blood Cell Counts Predict Distinct Endoscopic Phenotypes In Eosinophilic Esophagitis. Journal Of Allergy And Clinical Immunology 2022, 149: ab204. DOI: 10.1016/j.jaci.2021.12.670.Peer-Reviewed Original Research
2021
Low IgG trough and lymphocyte subset counts are associated with hospitalization for COVID-19 in patients with primary antibody deficiency
Kuster JK, Unlu S, Makin TA, Par-Young J, Simonov M, Shafi S, Balanda M, Randolph C, Steele R, Hsu FI, Price C, Kohli-Pamnani A, Borish L, Lawrence MG, Kang I, Shin JJ. Low IgG trough and lymphocyte subset counts are associated with hospitalization for COVID-19 in patients with primary antibody deficiency. The Journal Of Allergy And Clinical Immunology In Practice 2021, 10: 633-636.e3. PMID: 34929372, PMCID: PMC8683251, DOI: 10.1016/j.jaip.2021.11.030.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
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Overview
Clinical Specialties
Internal Medicine; Allergy & Clinical Immunology
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Penicillin Allergy
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Yale Medicine News
News
News
- June 07, 2024
Yale Pediatrics Announces New Section of Pediatric Immunology and Rheumatology and Interim Section Chief, Ian Ferguson, MD
- February 23, 2024
Department of Internal Medicine Promotions and Appointments (February 2024)
- June 13, 2023
Shin Awarded Immune Deficiency Foundation Grant
- November 02, 2022
How A Common Gene Variant Influences Your Risk of Severe Illness From COVID-19