MicroRNA‐455 regulates brown adipogenesis via a novel HIF1an‐AMPK‐PGC1α signaling network
Zhang H, Guan M, Townsend K, Huang T, An D, Yan X, Xue R, Schulz T, Winnay J, Mori M, Hirshman M, Kristiansen K, Tsang J, White A, Cypess A, Goodyear L, Tseng Y. MicroRNA‐455 regulates brown adipogenesis via a novel HIF1an‐AMPK‐PGC1α signaling network. EMBO Reports 2015, 16: 1378-1393. PMID: 26303948, PMCID: PMC4766451, DOI: 10.15252/embr.201540837.Peer-Reviewed Original ResearchMeSH KeywordsAdipocytes, BrownAdipogenesisAdipose Tissue, WhiteAMP-Activated Protein KinasesAnimalsCell DifferentiationCells, CulturedCold TemperatureHumansMiceMice, TransgenicMicroRNAsMixed Function OxygenasesNerve Tissue ProteinsNuclear ProteinsOrganelle BiogenesisPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaRepressor ProteinsSignal TransductionThermogenesisTranscription FactorsConceptsBrown adipose tissueBrown adipogenesisMiR-455Potential therapeutic targetSubcutaneous white fatTransgenic mice displayBrown adipocyte differentiationMRNA microarray profilingHuman metabolic disordersMicroRNA-455Metabolic disordersWhite fatTherapeutic targetAdipose tissueMice displayCold exposureAdipocyte differentiationAdipogenic differentiationAdipogenic programMicroarray profilingAdipogenesisMitochondrial biogenesisFunction studiesKey regulatorNew regulator