2008
A regulatable switch mediates self-association in an immunoglobulin fold
Calabrese MF, Eakin CM, Wang JM, Miranker AD. A regulatable switch mediates self-association in an immunoglobulin fold. Nature Structural & Molecular Biology 2008, 15: 965-971. PMID: 19172750, PMCID: PMC2680708, DOI: 10.1038/nsmb.1483.Peer-Reviewed Original ResearchMeSH KeywordsAmyloidAmyloidosisBeta 2-MicroglobulinCopperCrystallography, X-RayElectron Spin Resonance SpectroscopyHumansHydrophobic and Hydrophilic InteractionsImmunoglobulinsIn Vitro TechniquesModels, BiologicalModels, MolecularMultiprotein ComplexesProtein FoldingProtein Interaction Domains and MotifsProtein Structure, QuaternaryRenal Dialysis
2003
Modifying the oligomeric state of cyclic amidase and its effect on enzymatic catalysis
Yoon J, Oh B, Kim K, Park JE, Wang J, Kim HS, Kim Y. Modifying the oligomeric state of cyclic amidase and its effect on enzymatic catalysis. Biochemical And Biophysical Research Communications 2003, 310: 651-659. PMID: 14521961, DOI: 10.1016/j.bbrc.2003.09.056.Peer-Reviewed Original ResearchMeSH KeywordsAmidohydrolasesAmino AcidsCatalysisDimerizationHydrophobic and Hydrophilic InteractionsModels, MolecularMolecular WeightMutagenesisProtein Structure, SecondaryConceptsCyclic amidasesD-hydantoinaseCatalytic propertiesHydrophobic interaction domainCatalytic activityEnzymatic catalysisHydrophobic interactionsCyclic ureidesReversible hydrolysisDimeric formHydrophobic patchDimeric interactionsOligomeric stateSpecific activityTetramerKinetic propertiesCatalysisLow specific activityDihydropyrimidinesPropertiesHydantoinsDimersDihydroorotaseHydrolysisInteraction