About
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Assistant Professor Adjunct
Appointments
Nephrology
Assistant Professor AdjunctPrimary
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Research
Overview
The metanephos (the permanent kidney in mammals) develops as a result of the interplay between metanephric mesenchyme (a clump of embryonic renal stem cells that root from intermediate mesoderm) and ureter bud (epithelial structure that derives from Wolffian duct). One of our long term goals is to understand the molecular events that govern kidney formation and functional maintenance by analyzing genetic or epigenetic factors. One of our other goals is to delineate pathways or to devise new methods that can induce embryonic stem cells toward renal lineage, which may eventually pave the way for repair/regeneration of renal epithelium.
Medical Research Interests
Congenital, Hereditary, and Neonatal Diseases and Abnormalities; WAGR Syndrome
Research at a Glance
Yale Co-Authors
Frequent collaborators of Jiankan Guo's published research.
Publications Timeline
A big-picture view of Jiankan Guo's research output by year.
Lloyd G. Cantley, MD
Diane Krause, MD, PhD
Leyuan Xu, PhD
Thomas Ardito, BS
13Publications
469Citations
Publications
2024
Myofibroblast-Macrophage Cross-Talk Supports Proliferative Tubule Repair after Kidney Injury
Bharathan B, Xu L, Guo J, Cantley L. Myofibroblast-Macrophage Cross-Talk Supports Proliferative Tubule Repair after Kidney Injury. Journal Of The American Society Of Nephrology 2024, 35: 10.1681/asn.20249phzkecs. DOI: 10.1681/asn.20249phzkecs.Peer-Reviewed Original ResearchVCAM-1 mediates proximal tubule-immune cell cross talk in failed tubule recovery during AKI-to-CKD transition
Melchinger I, Guo K, Li X, Guo J, Cantley L, Xu L. VCAM-1 mediates proximal tubule-immune cell cross talk in failed tubule recovery during AKI-to-CKD transition. American Journal Of Physiology. Renal Physiology 2024, 327: f610-f622. PMID: 39116349, PMCID: PMC11483080, DOI: 10.1152/ajprenal.00076.2024.Peer-Reviewed Original ResearchAltmetricConceptsAcute kidney injuryChronic kidney diseaseVCAM-1 expressionProximal tubule cellsVCAM-1Tubule cellsKidney Precision Medicine ProjectProinflammatory cytokinesAcute kidney injury to chronic kidney diseaseModel of chronic kidney diseaseExpression of vascular cell adhesion protein 1Cell adhesion pathwaysInflammatory response to injuryInjured proximal tubule cellsVascular cell adhesion protein 1Mouse model of chronic kidney diseaseRisk of progressionChronic kidney disease transitionIncreased immune cell adhesionVCAM-1-positive cellsOverexpression of VCAM-1Inhibition of NF-kB signalingActivation of NF-kBImmune cell adhesionSingle-cell transcriptome analysis
2022
Authors' Reply: Most Arginase-1 Positive Cells Are Likely Injured S3 Proximal Tubular Cells Carrying Upregulated Phagocytotic Capacity rather than M2 Macrophages—Too Many To Be True
Shin N, Marlier A, Xu L, Doilicho N, Linberg D, Guo J, Cantley L. Authors' Reply: Most Arginase-1 Positive Cells Are Likely Injured S3 Proximal Tubular Cells Carrying Upregulated Phagocytotic Capacity rather than M2 Macrophages—Too Many To Be True. Journal Of The American Society Of Nephrology 2022, 33: 2124-2125. PMID: 36316094, PMCID: PMC9678031, DOI: 10.1681/asn.2022070836.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsImmune-Mediated Tubule Atrophy Promotes AKI to CKD Transition
Xu L, Guo J, Moledina D, Cantley L. Immune-Mediated Tubule Atrophy Promotes AKI to CKD Transition. Journal Of The American Society Of Nephrology 2022, 33: 872-872. DOI: 10.1681/asn.20223311s1872b.Peer-Reviewed Original Research
2011
Increased Tubular Proliferation as an Adaptive Response to Glomerular Albuminuria
Guo JK, Marlier A, Shi H, Shan A, Ardito TA, Du ZP, Kashgarian M, Krause DS, Biemesderfer D, Cantley LG. Increased Tubular Proliferation as an Adaptive Response to Glomerular Albuminuria. Journal Of The American Society Of Nephrology 2011, 23: 429-437. PMID: 22193389, PMCID: PMC3294312, DOI: 10.1681/asn.2011040396.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAlbuminuriaAnimalsAxl Receptor Tyrosine KinaseCell ProliferationDisease Models, AnimalFemaleHeparin-binding EGF-like Growth FactorIntegrasesIntercellular Signaling Peptides and ProteinsIntracellular Signaling Peptides and ProteinsKidney GlomerulusKidney Tubules, ProximalMaleMembrane ProteinsMiceMice, TransgenicPodocytesProteinuriaProto-Oncogene ProteinsReceptor Protein-Tyrosine KinasesConceptsGlomerular proteinuriaTubular injuryTubular proliferationStructural glomerular injuryProteinuric renal diseaseOnset of albuminuriaRenal tubular atrophyDiphtheria toxin receptorRenal tubular cellsProximal tubule cellsGlomerular albuminuriaRenal failureSystemic inflammationTubular damageProgressive glomerulosclerosisRenal diseaseTubular atrophyGlomerular injuryRenal responsePodocyte lossProliferative responseTubular cellsAnimal modelsProteinuriaReceptor Axl
2010
Cellular Maintenance and Repair of the Kidney
Guo JK, Cantley LG. Cellular Maintenance and Repair of the Kidney. Annual Review Of Physiology 2010, 72: 357-376. PMID: 20148680, DOI: 10.1146/annurev.physiol.010908.163245.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMultiple cell typesBone marrow-derived stemPrecise structural arrangementCellular maintenanceEx vivo programmingRenal lineagesAdult organsMammalian kidneyCell typesStem cellsProgenitor cellsComplex organRepair processCurrent understandingCell viabilityCellsFunctional stabilityCompartmentsLineagesCell injuryMaintenanceVivo programmingStructural arrangementOrgansActive reabsorption
2008
Erythropoietin expands a stromal cell population that can mediate renoprotection
Bi B, Guo J, Marlier A, Lin SR, Cantley LG. Erythropoietin expands a stromal cell population that can mediate renoprotection. American Journal Of Physiology. Renal Physiology 2008, 295: f1017-f1022. PMID: 18653480, PMCID: PMC2576137, DOI: 10.1152/ajprenal.90218.2008.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsAdministration of EPOMarrow stromal cellsTubular epithelial cellsRenoprotective effectsTubular cellsCisplatin-treated miceEpithelial cellsEndothelial progenitor cellsSecretion of factorsStromal cell populationsDeprivation-induced cell deathRenal functionTubular injuryCisplatin administrationPeripheral circulationIntraperitoneal injectionSerum deprivation-induced cell deathToxic injuryBone marrowStromal cellsVivo expansionInjuryProgenitor cellsAdministrationEPO receptor
2006
Prevention of mesangial sclerosis by bone marrow transplantation
Guo J, Ardito TA, Kashgarian M, Krause DS. Prevention of mesangial sclerosis by bone marrow transplantation. Kidney International 2006, 70: 910-913. PMID: 16850025, DOI: 10.1038/sj.ki.5001698.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsBone marrow transplantationMesangial sclerosisMarrow transplantationUrinary albumin lossSimilar therapeutic effectsOnset of diseaseWild-type BMIntrarenal administrationRenal functionRenal histologyRenal diseaseDisease onsetRenal pathologyBM cellsTherapeutic effectEngraftment levelsRenal cellsAlbumin lossKidney samplesMiceSclerosisTransplantationUntreated controlsDiseaseAdministrationAn Inducible Mouse Model for PAX2-Dependent Glomerular Disease: Insights into a Complex Pathogenesis
Wagner KD, Wagner N, Guo JK, Elger M, Dallman MJ, Bugeon L, Schedl A. An Inducible Mouse Model for PAX2-Dependent Glomerular Disease: Insights into a Complex Pathogenesis. Current Biology 2006, 16: 793-800. PMID: 16631587, DOI: 10.1016/j.cub.2006.02.072.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsInducible mouse modelGlomerular diseaseMouse modelAngiotensin-converting enzyme inhibitorEnd-stage renal failureTreatment of miceHealthy adult animalsRenal failureRenal functionRenal diseaseComplex pathogenesisNephrin expressionEnzyme inhibitorsDiseaseAdult animalsPodocytesDedifferentiated phenotypePersistent expressionMature podocytesPAX2MicePax genesFunctional relevanceTranscriptional repressorActivation
2005
Bone Marrow Transplantation Can Attenuate the Progression of Mesangial Sclerosis
Guo J, Schedl A, Krause DS. Bone Marrow Transplantation Can Attenuate the Progression of Mesangial Sclerosis. Stem Cells 2005, 24: 406-415. PMID: 16150922, DOI: 10.1634/stemcells.2005-0139.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsBone marrow transplantationBM transplantationWild-type BMMesangial sclerosisMarrow transplantationBeneficial effectsLong-term beneficial effectsLower urinary albuminBM-derived cellsDonor BM cellsWild-type recipientsSignificant beneficial effectLong-term improvementProlongation of lifespanMaximal ameliorationRenal diseaseUrinary albuminRenal parenchymaBM cellsTherapeutic effectAlbuminuriaTransplantationTherapeutic potentialLethal doseHeterozygous mice
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News
- February 15, 2023
Celebrating New Faculty, Staff, Postdocs & Postgrads! (February 2023)
- March 24, 2021
Donors step up to help YSM respond to COVID-19 needs
- April 19, 2020Source: WNPR
Chinese American Community In Connecticut Makes Equipment Donation To Fight COVID-19
- April 14, 2020Source: New Haven Register
Opinion: Chinese-Americans play key role in delivering life-saving equipment
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