2018
Flexible Learning-Free Segmentation and Reconstruction of Neural Volumes
Shahbazi A, Kinnison J, Vescovi R, Du M, Hill R, Joesch M, Takeno M, Zeng H, da Costa NM, Grutzendler J, Kasthuri N, Scheirer WJ. Flexible Learning-Free Segmentation and Reconstruction of Neural Volumes. Scientific Reports 2018, 8: 14247. PMID: 30250218, PMCID: PMC6155135, DOI: 10.1038/s41598-018-32628-3.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsAnimalsImage Processing, Computer-AssistedImaging, Three-DimensionalMachine LearningMiceSynchrotronsX-Ray MicrotomographyConceptsGigabytes of dataSupervised learning methodsHigh-energy synchrotron X-ray microtomographyHigh-quality reconstructionComputer visionHigh biological fidelityVirtual eyeSpectral confocal reflectance microscopyStack of imagesLearning methodsPipeline reconstructionContextual cluesDifferent modalitiesNeural volumeMouse datasetsBiological fidelityImagesData collectionPipelineGigabytesSegmentationMachineAlgorithmDatasetSufficient quality
2011
Transcranial Two-Photon Imaging of the Living Mouse Brain
Grutzendler J, Yang G, Pan F, Parkhurst CN, Gan WB. Transcranial Two-Photon Imaging of the Living Mouse Brain. Cold Spring Harbor Protocols 2011, 2011: pdb.prot065474. PMID: 21880826, PMCID: PMC4641516, DOI: 10.1101/pdb.prot065474.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainImage Processing, Computer-AssistedMiceMicroscopy, ConfocalMicroscopy, FluorescenceNeuroimagingSkullConceptsMouse brainAxonal varicositiesSurgical proceduresDendritic spinesSide effectsBrain cellsTwo-photon imagingInvasive methodBlood vesselsSame animalsPathological conditionsTwo-photon microscopyIntact skullBrainTranscranialImagingMicrogliaSurgeryVaricositiesImaging methodNeuronsLong time intervalsSpine
2007
Various Dendritic Abnormalities Are Associated with Fibrillar Amyloid Deposits in Alzheimer's Disease
GRUTZENDLER J, HELMIN K, TSAI J, GAN W. Various Dendritic Abnormalities Are Associated with Fibrillar Amyloid Deposits in Alzheimer's Disease. Annals Of The New York Academy Of Sciences 2007, 1097: 30-39. PMID: 17413007, DOI: 10.1196/annals.1379.003.Peer-Reviewed Original ResearchMeSH KeywordsAlzheimer DiseaseAmyloid beta-Protein PrecursorAnimalsAtrophyCell SizeDendritesDendritic SpinesHumansImage Processing, Computer-AssistedMiceMice, TransgenicMicroscopy, ConfocalNeuronsPlaque, AmyloidPresenilin-1SynapsesConceptsAmyloid depositsAlzheimer's diseasePSAPP miceFibrillar amyloid depositsAmyloid depositionDendritic abnormalitiesHuman AD tissueFibrillar amyloid depositionHuman AD brainsTransgenic mouse modelHuman postmortem brainDystrophic neuritesSpine lossAD brainAD tissueAmyloid plaquesCommon abnormalityMouse modelPostmortem brainsDendritic spinesNeuronal circuitsVaricosity formationSynaptic structureDiseaseDendritic branches