2024
Single-cell transcriptomic and proteomic analysis of Parkinson’s disease brains
Zhu B, Park J, Coffey S, Russo A, Hsu I, Wang J, Su C, Chang R, Lam T, Gopal P, Ginsberg S, Zhao H, Hafler D, Chandra S, Zhang L. Single-cell transcriptomic and proteomic analysis of Parkinson’s disease brains. Science Translational Medicine 2024, 16: eabo1997. PMID: 39475571, DOI: 10.1126/scitranslmed.abo1997.Peer-Reviewed Original ResearchConceptsProteomic analysisAlzheimer's diseasePrefrontal cortexBrain cell typesGenetics of PDParkinson's diseaseCell-cell interactionsChaperone expressionSingle-nucleus transcriptomesExpressed genesTranscriptional changesPostmortem human brainPostmortem brain tissueDiseased brainSynaptic proteinsSingle-cellDown-regulationBrain cell populationsBrain regionsCell typesNeurodegenerative disordersLate-stage PDParkinson's disease brainsDisease etiologyNeuronal vulnerability
2015
Huntingtin-Associated Protein 1 Interacts with Breakpoint Cluster Region Protein to Regulate Neuronal Differentiation
Huang PT, Chen CH, Hsu IU, Salim S, Kao SH, Cheng CW, Lai CH, Lee CF, Lin YF. Huntingtin-Associated Protein 1 Interacts with Breakpoint Cluster Region Protein to Regulate Neuronal Differentiation. PLOS ONE 2015, 10: e0116372. PMID: 25671650, PMCID: PMC4324908, DOI: 10.1371/journal.pone.0116372.Peer-Reviewed Original ResearchConceptsBreakpoint cluster region proteinMicrotubule-dependent traffickingNeuronal differentiationRho GTPase regulatorsRegion proteinsProtein 1 interactsNeuro-2a cellsExtracellular signalsBrain-enriched proteinProteomic analysisGTPase regulatorDownstream effectorsPostnatal lethalityHAP1Neuronal cellsWild-type mouse brainProtein 1TraffickingNeurite outgrowthTropomyosin-related kinaseProteinKinaseNeurodegenerative diseasesDifferentiationMicrotubules