I-Uen "Yvonne" Hsu, PhD
Associate Research ScientistAbout
Research
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Featured Publications
Lineage and organ signals sequentially build organ intrinsic nervous systems
Hsu I, Zhao J, Guo Y, Xu Q, Shao Y, Wang R, Yin D, Ghoshal K, Mourad R, Pozzi A, Halabi C, Young L, Zhao H, Zhang L, Chang R. Lineage and organ signals sequentially build organ intrinsic nervous systems. Nature 2026, 655: 429-437. PMID: 42129551, PMCID: PMC13345970, DOI: 10.1038/s41586-026-10490-y.Peer-Reviewed Original ResearchStac protein regulates release of neuropeptides
Hsu IU, Linsley JW, Zhang X, Varineau JE, Berkhoudt DA, Reid LE, Lum MC, Orzel AM, Leflein A, Xu H, Collins CA, Hume RI, Levitan ES, Kuwada JY. Stac protein regulates release of neuropeptides. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 29914-29924. PMID: 33168737, PMCID: PMC7703553, DOI: 10.1073/pnas.2009224117.Peer-Reviewed Original ResearchAnimalsAnimals, Genetically ModifiedBehavior Observation TechniquesBehavior, AnimalCalcium ChannelsDrosophila melanogasterDrosophila ProteinsFemaleIntracellular Signaling Peptides and ProteinsIntravital MicroscopyLarvaMaleModels, AnimalMotor NeuronsMuscle, SkeletalNeuromuscular JunctionNeuropeptidesOptical ImagingPatch-Clamp TechniquesPresynaptic Terminals
2026
Single-cell transcriptomic atlas of Alzheimer's disease middle temporal gyrus reveals region, cell type, and sex specificity of gene expression with novel genetic risk for MERTK in female.
Zhang L, Liu T, He C, Russo A, Coffey S, Yin D, Hsu I, Zhang C, Ye Y, Su C, Spurrier J, Nicholson L, Kunkle B, Martin E, Rodriguez O, Gomez L, Chang R, Ghosh S, Gopal P, Hafler D, Zhao H, Strittmatter S. Single-cell transcriptomic atlas of Alzheimer's disease middle temporal gyrus reveals region, cell type, and sex specificity of gene expression with novel genetic risk for MERTK in female. Journal Of Alzheimer’s Disease 2026, 13872877261480719. PMID: 42678676, DOI: 10.1177/13872877261480719.Peer-Reviewed Original ResearchThe intrinsic cardiac nervous system is essential for cardiac function and survival
Xu Q, Applegate M, Hsu I, Kogan R, Hafez O, Wang R, Coronado P, Young L, Zeng X, Zhang L, Chang R. The intrinsic cardiac nervous system is essential for cardiac function and survival. Cell 2026, 189: 6061-6077.e8. PMID: 42486084, PMCID: PMC13527665, DOI: 10.1016/j.cell.2026.06.040.Peer-Reviewed Original Research
2025
Two Specialized Intrinsic Cardiac Neuron Types Safeguard Heart Homeostasis and Stress Resilience.
Xu QJ, Applegate MC, Hsu IU, Kogan RP, Hafez OA, Wang RL, Rios Coronado PE, Young LH, Zeng X, Zhang L, Chang RB. Two Specialized Intrinsic Cardiac Neuron Types Safeguard Heart Homeostasis and Stress Resilience. BioRxiv 2025 PMID: 40661461, DOI: 10.1101/2025.06.13.659555.Peer-Reviewed Original Research
2024
Single-cell transcriptomic and proteomic analysis of Parkinson’s disease brains
Zhu B, Park J, Coffey S, Russo A, Hsu I, Wang J, Su C, Chang R, Lam T, Gopal P, Ginsberg S, Zhao H, Hafler D, Chandra S, Zhang L. Single-cell transcriptomic and proteomic analysis of Parkinson’s disease brains. Science Translational Medicine 2024, 16: eabo1997-eabo1997. PMID: 39475571, PMCID: PMC12372474, DOI: 10.1126/scitranslmed.abo1997.Peer-Reviewed Original Research
2023
Acrolein adducts and responding autoantibodies correlate with metabolic disturbance in Alzheimer’s disease
Sanotra M, Kao S, Lee C, Hsu C, Huang W, Chang T, Tu F, Hsu I, Lin Y. Acrolein adducts and responding autoantibodies correlate with metabolic disturbance in Alzheimer’s disease. Alzheimer's Research & Therapy 2023, 15: 115. PMID: 37349844, PMCID: PMC10286356, DOI: 10.1186/s13195-023-01261-2.Peer-Reviewed Original Research
2020
Dstac Regulates Excitation-Contraction Coupling in Drosophila Body Wall Muscles
Hsu IU, Linsley JW, Reid LE, Hume RI, Leflein A, Kuwada JY. Dstac Regulates Excitation-Contraction Coupling in Drosophila Body Wall Muscles. Frontiers In Physiology 2020, 11: 573723. PMID: 33123029, PMCID: PMC7573238, DOI: 10.3389/fphys.2020.573723.Peer-Reviewed Original Research
2019
Reduction of AHI1 in the serum of Taiwanese with probable Alzheimer’s disease
Sheu JJ, Yang LY, Sanotra MR, Wang ST, Lu HT, Kam RSY, Hsu IU, Kao SH, Lee CK, Shieh JC, Lin YF. Reduction of AHI1 in the serum of Taiwanese with probable Alzheimer’s disease. Clinical Biochemistry 2019, 76: 24-30. PMID: 31786207, DOI: 10.1016/j.clinbiochem.2019.11.011.Peer-Reviewed Original Research
2018
Elevated IgM against Nε-(Carboxyethyl)lysine-modified Apolipoprotein A1 peptide 141–147 in Taiwanese with Alzheimer's disease
Lin CY, Sheu JJ, Tsai IS, Wang ST, Yang LY, Hsu IU, Chang HW, Lee HM, Kao SH, Lee CK, Chen CH, Lin YF. Elevated IgM against Nε-(Carboxyethyl)lysine-modified Apolipoprotein A1 peptide 141–147 in Taiwanese with Alzheimer's disease. Clinical Biochemistry 2018, 56: 75-82. PMID: 29680706, DOI: 10.1016/j.clinbiochem.2018.04.009.Peer-Reviewed Original ResearchAgedAged, 80 and overAlzheimer DiseaseAntibody SpecificityApolipoprotein A-IAutoantibodiesAutoimmunityBiomarkersCase-Control StudiesEnzyme-Linked Immunosorbent AssayFemaleGlycation End Products, AdvancedHumansImmunoglobulin MLysineMalePeptide FragmentsProtein Processing, Post-TranslationalPsychiatric Status Rating ScalesROC CurveTaiwanUp-Regulation
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