Georges El Fakhri, PhD, DABR
Elizabeth Mears and House Jameson Professor of Radiology and Biomedical Imaging and of Biomedical Informatics & Data ScienceCards
About
Research
Publications
2024
The role of parvalbumin interneuron dysfunction across neurodegenerative dementias
Smeralda C, Pandit S, Turrini S, Reilly J, Palmisano A, Sprugnoli G, Hampel H, Benussi A, Borroni B, Press D, Rotenberg A, El Fakhri G, Koch G, Rossi S, Santarnecchi E. The role of parvalbumin interneuron dysfunction across neurodegenerative dementias. Ageing Research Reviews 2024, 102509. PMID: 39306248, DOI: 10.1016/j.arr.2024.102509.Peer-Reviewed Original ResearchInterneuron dysfunctionCortical hyperexcitabilityTherapeutic targetCortical excitation/inhibition balanceRhythm disruptionFast-spikingPV+ cellsBasket neuronsPotential therapeutic targetInhibitory interneuronsExcitation/inhibition balanceOscillatory disruptionsSymptom onsetNovel biomarkersHyperexcitabilityDysfunctionNeuronal deathOscillatory activityDementia with Lewy bodiesPathophysiological frameworkClinical symptom onsetFrontotemporal dementiaDesign Optimisation of a Flat-Panel, Limited-Angle TOF-PET Scanner: A Simulation Study
Orehar M, Dolenec R, Fakhri G, Korpar S, Križan P, Razdevšek G, Marin T, Žontar D, Pestotnik R. Design Optimisation of a Flat-Panel, Limited-Angle TOF-PET Scanner: A Simulation Study. Diagnostics 2024, 14: 1976. PMID: 39272760, DOI: 10.3390/diagnostics14171976.Peer-Reviewed Original ResearchTime-of-flight positron emission tomographyTOF-PET scannerNEMA NU 2Evaluate spatial resolutionPET detectorsNU 2Scintillation materialsBiograph VisionRing scannerLimited-angleScanner designReadout levelsPoint sourcesFlat panel geometryClinical scannerSpatial resolutionReadout strategySingle-crystalImage qualityScintillationScannerFlat panelDesign parametersDetectorDesign optimisationInvestigating muscle coordination patterns with Granger causality analysis in protrusive motion from tagged and diffusion MRI
Park H, Xing F, Stone M, Kang H, Liu X, Zhuo J, Fels S, Reese T, Wedeen V, Fakhri G, Prince J, Woo J. Investigating muscle coordination patterns with Granger causality analysis in protrusive motion from tagged and diffusion MRI. JASA Express Letters 2024, 4: 095201. PMID: 39240196, PMCID: PMC11384280, DOI: 10.1121/10.0028500.Peer-Reviewed Original ResearchThe United States Department of Energy and National Institutes of Health Collaboration: Medical Care Advances by Discovery in Radiation Detection
Buchsbaum J, Capala J, Obcemea C, Keppel C, Asai M, Chen G, Christy M, Fakhri G, Gueye P, Pogue B, Ruckman L, Tourassi G, Vetter K, Zhao W, Squires A, Saboury B, Wang G, Domurat‐Sousa K, Weisenberger A. The United States Department of Energy and National Institutes of Health Collaboration: Medical Care Advances by Discovery in Radiation Detection. Medical Physics 2024 PMID: 39177300, DOI: 10.1002/mp.17333.Peer-Reviewed Original ResearchNational Institutes of HealthState-of-the-artApplication of artificial intelligenceDOE Office of ScienceArtificial intelligenceMedical care advancesImage reconstructionIn-person workshopsOffice of ScienceRadiation detectionHealth collaborationInstitutes of HealthCare advancesIn-personAreas of successAssociations of cerebral amyloid beta and tau with cognition from midlife
Gonzales M, O'Donnell A, Ghosh S, Thibault E, Tanner J, Satizabal C, Decarli C, Fakhri G, Johnson K, Beiser A, Seshadri S, Pase M. Associations of cerebral amyloid beta and tau with cognition from midlife. Alzheimer's & Dementia 2024, 20: 5901-5911. PMID: 39039896, DOI: 10.1002/alz.14060.Peer-Reviewed Original ResearchApolipoprotein E e4Associated with cognitionTau positron emission tomographyPositron emission tomographyWorsening cognitionCommunity-based cohortYoung adultsApolipoprotein EStudy investigated associationsPoor visuospatial skillsDementia preventionTargeted early interventionE4 statusCerebral amyloid-betaEffect modifiersHigher amyloidAPOE e4 carriersCognitive vulnerabilityAssociation of amyloidVisuospatial skillsResilience factorsEarly interventionYounger ageCognitionE4 carriersEffects of List-Mode Based Intra-Frame Motion Correction in Dynamic Brain PET Imaging
Tiss A, Chemli Y, Guehl N, Marin T, Johnson K, Fakhri G, Ouyang J. Effects of List-Mode Based Intra-Frame Motion Correction in Dynamic Brain PET Imaging. IEEE Transactions On Radiation And Plasma Medical Sciences 2024, PP: 1-1. DOI: 10.1109/trpms.2024.3432322.Peer-Reviewed Original ResearchAdvances and Insights in Positron Emission Tomography Tracers for Metabotropic Glutamate Receptor 4 Imaging
Wang J, Li Y, Fakhri G. Advances and Insights in Positron Emission Tomography Tracers for Metabotropic Glutamate Receptor 4 Imaging. Journal Of Medicinal Chemistry 2024, 67: 10517-10529. PMID: 38924702, PMCID: PMC11290609, DOI: 10.1021/acs.jmedchem.3c02431.Peer-Reviewed Original ResearchConceptsPositive allosteric modulatorsPositron emission tomographyPositron emission tomography radioligandsAllosteric modulatorsMGluR4 positive allosteric modulatorsMetabotropic glutamate receptor subtype 4PET ligandNeurological disordersPositron emission tomography tracersEmission tomographySubtype 4Molecular imaging modalitiesEffective treatmentMetabotropicDisordersParent drugImaging modalitiesPET tracersMGluR4Therapeutic targetPositron emitting radioisotopesSelection of lead compoundsLiving subjectsPositronQuantitative accuracyAccelerated 3D metabolite T1 mapping of the brain using variable‐flip‐angle SPICE
Zhao Y, Li Y, Guo R, Jin W, Sutton B, Ma C, Fakhri G, Li Y, Luo J, Liang Z. Accelerated 3D metabolite T1 mapping of the brain using variable‐flip‐angle SPICE. Magnetic Resonance In Medicine 2024, 92: 1310-1322. PMID: 38923032, DOI: 10.1002/mrm.30200.Peer-Reviewed Original ResearchConceptsLow-rank tensor modelGeneralized series modelMetabolite TExperimental resultsBrain metabolitesClinically acceptable scan timeEfficient encodingPhantom experimental resultsAcceptable scan timeNoisy dataSparse samplingImaging problemsData processingHealthy subject dataVariable flip angleFlip angleTensor modelSaturation effectsQuantitative metabolic imagingMRSI techniquePhantomScan timeData acquisitionMetabolic imagingT1 mappingAssociation of T-cell subtypes with macrophage-specific arterial infiltration in PWH.
Schnittman S, Talathi R, Wilks M, Hedgire S, Lu M, Fourman L, Alagpulinsa D, Stockman S, White K, Wallis Z, Autissier P, Stanley T, Lee H, Honigberg M, El-Fakhri G, Williams K, Zanni M, Grinspoon S, Toribio M. Association of T-cell subtypes with macrophage-specific arterial infiltration in PWH. AIDS 2024 PMID: 38905489, DOI: 10.1097/qad.0000000000003967.Peer-Reviewed Original ResearchArterial infiltrationCardiovascular diseaseIncreased risk of cardiovascular diseaseHuman immunodeficiency virusT cell subtypesT lymphocyte subpopulationsRisk of cardiovascular diseaseSystemic monocyte activationCardiovascular disease riskImmunodeficiency virusMonocyte activationHIV statusIncreased riskRelevant to atherogenesisHIVInfiltrationGeneral populationPWHEvidence of interactionSubtypesDiseaseSubpopulationsAtherogenesisDiffusion Model-Based Posterior Distribution Prediction for Kinetic Parameter Estimation in Dynamic PET
Djebra Y, Liu X, Marin T, Tiss A, Dhaynaut M, Guehl N, Johnson K, Fakhri G, Ma C, Ouyang J. Diffusion Model-Based Posterior Distribution Prediction for Kinetic Parameter Estimation in Dynamic PET. 2024, 00: 1-5. DOI: 10.1109/isbi56570.2024.10635805.Peer-Reviewed Original ResearchPosterior distributions of kinetic parametersDenoising diffusion probabilistic modelHyperphosphorylated tauP-tauDiffusion probabilistic modelAlzheimer's diseaseNeurodegenerative diseasesKinetic parametersPosterior distributionInference efficiencyComputational needsEstimate kinetic parametersProbabilistic modelComputation time