2010
Adaptive Unfolded Protein Response Attenuates Alcohol-Induced Pancreatic Damage
Lugea A, Tischler D, Nguyen J, Gong J, Gukovsky I, French SW, Gorelick FS, Pandol SJ. Adaptive Unfolded Protein Response Attenuates Alcohol-Induced Pancreatic Damage. Gastroenterology 2010, 140: 987-997.e8. PMID: 21111739, PMCID: PMC3057335, DOI: 10.1053/j.gastro.2010.11.038.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalAnimalsApoptosisApoptosis Regulatory ProteinsDisease Models, AnimalDNA-Binding ProteinsEndoplasmic ReticulumEthanolMaleMiceMice, Inbred BALB CMice, KnockoutPancreas, ExocrinePancreatitis, AlcoholicProtein Disulfide-IsomerasesRatsRats, WistarRegulatory Factor X Transcription FactorsStress, PhysiologicalTissue Culture TechniquesTranscription FactorsUnfolded Protein ResponseX-Box Binding Protein 1ConceptsProtein disulfide isomeraseX-box binding protein 1ER stressUPR regulatorOxidation of PDIER protein foldingDisulfide bond formationBinding protein 1Reticulum stress responseDisulfide isomeraseProtein foldingER functionProapoptotic signalsStress responseHuman disordersXBP1 deficiencyAcinar cell deathER dysfunctionCell deathXBP1 levelsAlcohol-induced ER stressPDI levelsProtein 1UPRWild-type mice
2002
Neutrophils and NADPH oxidase mediate intrapancreatic trypsin activation in murine experimental acute pancreatitis
Gukovskaya AS, Vaquero E, Zaninovic V, Gorelick FS, Lusis AJ, Brennan M, Holland S, Pandol SJ. Neutrophils and NADPH oxidase mediate intrapancreatic trypsin activation in murine experimental acute pancreatitis. Gastroenterology 2002, 122: 974-984. PMID: 11910350, DOI: 10.1053/gast.2002.32409.Peer-Reviewed Original ResearchConceptsIntrapancreatic trypsin activationAcute pancreatitisNADPH oxidaseTrypsin activationAdenine Dinucleotide Phosphate OxidaseParenchymal cell injuryExperimental acute pancreatitisNADPH oxidase activityPancreatic acinar tissueDigestive enzymesWestern blot analysisAntineutrophil serumPathologic activationCell injuryPancreatitisExperimental pancreatitisHigh dosesMarked attenuationNeutrophilsAbstractTextAcinar tissuePancreatic homogenatesReactive oxygen speciesMyeloperoxidaseMice