2021
Sex Differences in the Exocrine Pancreas and Associated Diseases
Wang M, Gorelick F, Bhargava A. Sex Differences in the Exocrine Pancreas and Associated Diseases. Cellular And Molecular Gastroenterology And Hepatology 2021, 12: 427-441. PMID: 33895424, PMCID: PMC8255941, DOI: 10.1016/j.jcmgh.2021.04.005.Peer-Reviewed Original ResearchConceptsPancreatic diseaseSex differencesExocrine pancreasLevels of estrogenAcute pancreatitis modelOverall health outcomesSex-specific mechanismsNormal exocrine pancreasG protein-coupled receptorsSex-specific changesMajor sex differencesObstructive etiologyPremenopausal womenProtein-coupled receptorsPancreatic surgeryAdrenal glandPancreatic histopathologyPancreatic secretionProtective effectLow prevalenceGranule numberDiagnostic criteriaPancreatitis modelPancreatic anatomyAssociated disease
2017
The serum protein renalase reduces injury in experimental pancreatitis
Kolodecik TR, Reed AM, Date K, Shugrue C, Patel V, Chung SL, Desir GV, Gorelick FS. The serum protein renalase reduces injury in experimental pancreatitis. Journal Of Biological Chemistry 2017, 292: 21047-21059. PMID: 29042438, PMCID: PMC5743078, DOI: 10.1074/jbc.m117.789776.Peer-Reviewed Original ResearchMeSH KeywordsAcinar CellsAnimalsAnti-Inflammatory Agents, Non-SteroidalBiomarkersCalcium SignalingCarbacholCell LineCeruletideEnzyme ActivationFluorescent Antibody Technique, IndirectGene Expression Regulation, EnzymologicHumansHypertensionLigandsMembrane Transport ModulatorsMiceMice, KnockoutMonoamine OxidasePancreasPancreatitisPlasma Membrane Calcium-Transporting ATPasesRecombinant Fusion ProteinsTaurolithocholic AcidConceptsRecombinant human renalaseAcute pancreatitisAcute injuryCell injuryAcinar cell injuryHuman acinar cellsCytosolic calcium levelsPlasma membrane calcium ATPasePancreatitis onsetIschemic injuryWT micePathological increaseHistological changesProtective effectSevere diseaseMurine modelMembrane calcium ATPasePancreatitisCalcium levelsExperimental pancreatitisBile acidsTissue damageRenalaseInjuryCerulein model