Evgeniy Potapenko
Associate Research ScientistCards
About
Research
Publications
2026
Amino Acid Sensing by the α-Cell Mitochondrial Phosphoenolpyruvate Cycle Regulates Intracellular Ca2+ Levels Without Affecting Glucagon Secretion.
Jin E, Foster H, Potapenko E, Huang S, Dong X, Hughes J, Merrins M. Amino Acid Sensing by the α-Cell Mitochondrial Phosphoenolpyruvate Cycle Regulates Intracellular Ca2+ Levels Without Affecting Glucagon Secretion. Diabetes 2026, 75: 483-493. PMID: 41525135, PMCID: PMC12928745, DOI: 10.2337/db25-0510.Peer-Reviewed Original ResearchThis study investigates how amino acid sensing in pancreatic α-cells via the mitochondrial phosphoenolpyruvate cycle regulates calcium levels but does not influence glucagon secretion, which is crucial for understanding diabetes-related glucagon dysregulation.
2023
Architecture of androgen receptor pathways amplifying glucagon-like peptide-1 insulinotropic action in male pancreatic β cells
Xu W, Qadir M, Nasteska D, de P, Gorvin C, Blandino-Rosano M, Evans C, Ho T, Potapenko E, Veluthakal R, Ashford F, Bitsi S, Fan J, Bhondeley M, Song K, Sure V, Sakamuri S, Schiffer L, Beatty W, Wyatt R, Frigo D, Liu X, Katakam P, Arlt W, Buck J, Levin L, Hu T, Kolls J, Burant C, Tomas A, Merrins M, Thurmond D, Bernal-Mizrachi E, Hodson D, Mauvais-Jarvis F. Architecture of androgen receptor pathways amplifying glucagon-like peptide-1 insulinotropic action in male pancreatic β cells. Cell Reports 2023, 42: 112529. PMID: 37200193, PMCID: PMC10312392, DOI: 10.1016/j.celrep.2023.112529.Peer-Reviewed Original ResearchA plasma membrane-associated glycolytic metabolon is functionally coupled to KATP channels in pancreatic α and β cells from humans and mice
Ho T, Potapenko E, Davis D, Merrins M. A plasma membrane-associated glycolytic metabolon is functionally coupled to KATP channels in pancreatic α and β cells from humans and mice. Cell Reports 2023, 42: 112394. PMID: 37058408, PMCID: PMC10513404, DOI: 10.1016/j.celrep.2023.112394.Peer-Reviewed Original Research
2020
Pyruvate Kinase Controls Signal Strength in the Insulin Secretory Pathway
Lewandowski SL, Cardone RL, Foster HR, Ho T, Potapenko E, Poudel C, VanDeusen HR, Sdao SM, Alves TC, Zhao X, Capozzi ME, de Souza AH, Jahan I, Thomas CJ, Nunemaker CS, Davis DB, Campbell JE, Kibbey RG, Merrins MJ. Pyruvate Kinase Controls Signal Strength in the Insulin Secretory Pathway. Cell Metabolism 2020, 32: 736-750.e5. PMID: 33147484, PMCID: PMC7685238, DOI: 10.1016/j.cmet.2020.10.007.Peer-Reviewed Original Research