Ernie Chen
About
Research
Publications
2025
MTHFR allele and one-carbon metabolic profile predict severity of COVID-19
Petrova B, Syphurs C, Culhane A, Chen J, Chen E, Cotsapas C, Esserman D, Montgomery R, Kleinstein S, Smolen K, Mendez K, Network I, Lasky-Su J, Steen H, Levy O, Diray-Arce J, Kanarek N. MTHFR allele and one-carbon metabolic profile predict severity of COVID-19. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2509118122. PMID: 41410771, PMCID: PMC12745694, DOI: 10.1073/pnas.2509118122.Peer-Reviewed Original ResearchConceptsSevere COVID-19High riskPublic health burdenHigh risk of severe diseaseEarly detection of patientsC677T alleleRisk of severe diseaseStudy of COVID-19 patientsEarly identificationRisk of severe COVID-19Early detectionDetection of patientsVaccine-acquired immunityHigher risk of severe COVID-19One-carbon metabolism pathwayBurden of SARS-CoV-2 infectionSARS-CoV-2 infectionSeverity of COVID-19COVID-19 patientsTargeted metabolite profilingVariant statusC677TRespiratory statusOne-carbon metabolismT alleleIdentifying one-carbon metabolism as a predictor of COVID-19 severity in the IMPACC cohort 3975
Syphurs C, Petrova B, Diray-Arce J, Culhane A, Chen J, Chen E, Montgomery R, Kleinstein S, Smolen K, Mendez K, Lasky-Su J, Steen H, Levy O, Kanarek N. Identifying one-carbon metabolism as a predictor of COVID-19 severity in the IMPACC cohort 3975. The Journal Of Immunology 2025, 214 DOI: 10.1093/jimmun/vkaf283.1713.Peer-Reviewed Original ResearchSevere SARS-CoV-2 infectionAdult COVID-19 patientsOne-carbon metabolism pathwaySARS-CoV-2 infectionCOVID-19 cohortCOVID-19 patientsEarly indicatorMTHFR geneMethionine cycleImmunophenotypic assessmentOne-carbon metabolismMTHFR variantsTrajectory groupsDisease progressionLongitudinal analysisMetabolic profilePredictors of COVID-19Respiratory illnessPatientsMetabolic characterizationLiquid chromatography-mass spectrometryCOVID-19 managementGenetic contributorsMethylation of DNACohort