Deus Thindwa, PhD
Associate Research Scientist in Epidemiology (Microbial Diseases)About
Research
Publications
2025
Leveraging paired serology to estimate the incidence of typhoidal Salmonella infection in the STRATAA study
Walker J, Russell P, Kermack L, Van T, Nga T, Mylona E, Camara S, Kim Y, Shrestha S, Gehlhaar A, Scott J, Khanam F, Shakya M, Thindwa D, Gordon M, Basnyat, Clemens J, Qadri F, Heyderman R, Dolecek C, Tonks S, Darton T, Pollard A, Baker S, Meiring J, Voysey M, Pitzer V, Group A. Leveraging paired serology to estimate the incidence of typhoidal Salmonella infection in the STRATAA study. PLOS Neglected Tropical Diseases 2025, 19: e0013612. PMID: 41066482, PMCID: PMC12527133, DOI: 10.1371/journal.pntd.0013612.Peer-Reviewed Original ResearchConceptsEnteric fever incidenceBlood culture surveillanceSalmonella infectionAntigenic targetsAge groupsStudy sitesEnteric fever casesMultiplex bead assaySalmonella serotypesPaired blood samplesConcentrations of IgG antibodiesSeroincidence estimatesSerological surveillanceSample of healthy childrenBlood culturesFever incidenceInfected participantsHealthy childrenSeroincidenceAt-risk populationsEndemic settingsBead assayPaired serologyIgG antibodiesBlood samplesHigh Propensity for Multidrug-Resistant Pneumococcal Shedding Among Adults Living With HIV on Stable Antiretroviral Therapy in Malawi
Sibale L, Kalata N, Mitole N, Nyazika T, Phiri J, Kusakala A, Khwiya M, Sagawa G, Lo S, Chaguza C, Thindwa D, Swarthout T, French N, Malisita K, Kamng'ona A, Ferreira D, Bentley S, Heyderman R, Kwambana-Adams B, Jambo K. High Propensity for Multidrug-Resistant Pneumococcal Shedding Among Adults Living With HIV on Stable Antiretroviral Therapy in Malawi. Open Forum Infectious Diseases 2025, 12: ofaf422. PMID: 40799787, PMCID: PMC12343114, DOI: 10.1093/ofid/ofaf422.Peer-Reviewed Original ResearchRisk of pneumococcal diseaseAntiretroviral therapyAntimicrobial resistancePneumococcal diseaseDay 3Carriage densityHIV- adultsPrevalence of pneumococcal carriageRisk factorsHigh riskMultidrug-resistant pneumococciPneumococcal carriage densityStable antiretroviral therapyCD4 cell countHIV viral loadHuman immunodeficiency virusAntimicrobial resistance profilesPneumococcal carriage prevalencePeripheral blood samplesHigh risk of pneumococcal diseaseStandard bacterial cultureAsymptomatic PLHIVHIV-uninfectedNasopharyngeal swab samplesImmunodeficiency virusThe Role of Viral Interference in Shaping RSV Epidemics Following the 2009 H1N1 Influenza Pandemic
Li K, Thindwa D, Weinberger D, Pitzer V. The Role of Viral Interference in Shaping RSV Epidemics Following the 2009 H1N1 Influenza Pandemic. Influenza And Other Respiratory Viruses 2025, 19: e70111. PMID: 40275825, PMCID: PMC12022500, DOI: 10.1111/irv.70111.Peer-Reviewed Original ResearchConceptsRespiratory syncytial virusRespiratory syncytial virus activityRespiratory syncytial virus epidemicsInfluenza pandemicViral interferenceLaboratory-confirmed RSV casesRSV epidemicsDecreased RSV infectionH1N1 influenza pandemicRSV infectionRSV seasonRSV casesSyncytial virusPandemic influenzaInfluenzaRSV activityCo-InfectionSurveillance dataEpidemicUnited StatesUS regionsH1N1The role of viral interference in shaping RSV epidemics following the 2009 H1N1 influenza pandemic.
Li K, Thindwa D, Weinberger DM, Pitzer VE. The role of viral interference in shaping RSV epidemics following the 2009 H1N1 influenza pandemic. MedRxiv 2025 PMID: 38464193, DOI: 10.1101/2024.02.25.24303336.Peer-Reviewed Original ResearchThe Complex Landscape of Updated Pneumococcal Conjugate Vaccines
Thindwa D, Shapiro E, Weinberger D. The Complex Landscape of Updated Pneumococcal Conjugate Vaccines. Open Forum Infectious Diseases 2025, 12: ofaf050. PMID: 39968305, PMCID: PMC11834978, DOI: 10.1093/ofid/ofaf050.Peer-Reviewed Original Research
2024
Estimating pneumococcal carriage dynamics in adults living with HIV in a mature infant pneumococcal conjugate vaccine programme in Malawi, a modelling study
Phiri J, Sibale L, Mlongoti L, Mitole N, Kusakala A, Khwiya M, Kayembe T, Lisimba E, Kapwata P, Malisita K, Chaguza C, Ferreira D, Thindwa D, Jambo K. Estimating pneumococcal carriage dynamics in adults living with HIV in a mature infant pneumococcal conjugate vaccine programme in Malawi, a modelling study. BMC Medicine 2024, 22: 419. PMID: 39334289, PMCID: PMC11438070, DOI: 10.1186/s12916-024-03631-5.Peer-Reviewed Original ResearchConceptsNon-PCV13 serotypesAntiretroviral therapyPneumococcal carriage prevalencePneumococcal carriageCarriage prevalenceHIV- adultsStudy groupCarriage acquisitionDetect pneumococcal carriageAntiretroviral therapy durationHuman immunodeficiency virusSocial economic statusPneumococcal conjugate vaccination programmeMultivariate longitudinal analysesPCV13 serotypesProlonged carriageImmunodeficiency virusMedian ageHIV individualsNasopharyngeal clearancePneumococcal serotypesALWHIVLatex agglutinationCulture microbiologyPoint prevalenceModelling Salmonella Typhi in high-density urban Blantyre neighbourhood, Malawi, using point pattern methods
Khaki J, Meiring J, Thindwa D, Henrion M, Jere T, Msuku H, Heyderman R, Gordon M, Giorgi E. Modelling Salmonella Typhi in high-density urban Blantyre neighbourhood, Malawi, using point pattern methods. Scientific Reports 2024, 14: 17164. PMID: 39060281, PMCID: PMC11282181, DOI: 10.1038/s41598-024-66436-9.Peer-Reviewed Original ResearchConceptsOrganism of typhoid feverHuman-restricted pathogenTyphoid riskPoint pattern methodsSalmonella typhiPoint pattern modelsTyphoid casesTyphoid feverFecal-oral routeCausative organismTyphoidHealth facility dataEnvironmental risk factorsRisk factorsTyphoid incidenceSpatial variationTyphiFacility dataIndividual-levelPathogensTemporal variationIncidencePathogen diversity and antimicrobial resistance transmission of Salmonella enterica serovars Typhi and Paratyphi A in Bangladesh, Nepal, and Malawi: a genomic epidemiological study
Dyson Z, Ashton P, Khanam F, Chirambo A, Shakya M, Meiring J, Tonks S, Karkey A, Msefula C, Clemens J, Dunstan S, Baker S, Dougan G, Pitzer V, Basnyat, Qadri F, Heyderman R, Gordon M, Pollard A, Holt K, Group S, Banda H, Biswas P, Bhuiyan A, Blohmke C, Darton T, Dolecek C, Dongol S, Mujadidi Y, Hill J, Hoang N, Jere T, Mbewe M, Msuku H, Nga T, Nkhata R, Rahman S, Rahman N, Saad N, Tan T, Thindwa D, Voysey M, Wachepa R. Pathogen diversity and antimicrobial resistance transmission of Salmonella enterica serovars Typhi and Paratyphi A in Bangladesh, Nepal, and Malawi: a genomic epidemiological study. The Lancet Microbe 2024, 5: 100841. PMID: 38996496, PMCID: PMC11300424, DOI: 10.1016/s2666-5247(24)00047-8.Peer-Reviewed Original ResearchParatyphi ASerovars TyphiPathogenic variantsAntimicrobial resistanceSalmonella enterica serovar TyphiEnteric feverAncestral state reconstructionS paratyphi ADeterminants of antimicrobial resistanceSingle-nucleotide variantsAntimicrobial resistance determinantsQuinolone-resistance mutationsAntimicrobial resistance transmissionCore genomePhylogenomic analysisAzithromycin resistance mutationsPhylogenetic analysisGenomic dataPopulation structurePathogen diversityS typhiTransmission of resistant strainsGenomic epidemiologyAntimicrobial resistant infectionsAge groupsGlobal patterns of rebound to normal RSV dynamics following COVID-19 suppression
Thindwa D, Li K, Cooper-Wootton D, Zheng Z, Pitzer V, Weinberger D. Global patterns of rebound to normal RSV dynamics following COVID-19 suppression. BMC Infectious Diseases 2024, 24: 635. PMID: 38918718, PMCID: PMC11201371, DOI: 10.1186/s12879-024-09509-4.Peer-Reviewed Original ResearchWorkshop on the design and use of clinical trials with multiple endpoints, with a focus on prevention of RSV
O. Prunas, J. Willemsen, J.L. Warren, L. et al.Peer-Reviewed Case Reports and Technical Notes
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