2020
Age-Related Structural and Functional Changes of the Hippocampus and the Relationship with Inhibitory Control
Hu S, Li CR. Age-Related Structural and Functional Changes of the Hippocampus and the Relationship with Inhibitory Control. Brain Sciences 2020, 10: 1013. PMID: 33352718, PMCID: PMC7766783, DOI: 10.3390/brainsci10121013.Peer-Reviewed Original ResearchStop-signal reaction timeGray matter volumeHippocampal gray matter volumePosterior hippocampusSequential effectsAge-related changesAnterior hippocampal activationTrial reaction timeStop-signal taskDistinct neural markersRight posterior hippocampusSignal reaction timeStop-signal probabilityRegional activityReaction timeAge-Related StructuralCognitive controlCognitive agingHippocampal activationProactive controlSignal taskBehavioral performanceAge-related reductionInhibitory controlHippocampal activity
2019
Neural correlates of enhanced response inhibition in the aftermath of stress
Chang J, Hu J, Li CR, Yu R. Neural correlates of enhanced response inhibition in the aftermath of stress. NeuroImage 2019, 204: 116212. PMID: 31546050, PMCID: PMC7509808, DOI: 10.1016/j.neuroimage.2019.116212.Peer-Reviewed Original ResearchConceptsInhibitory controlAcute stressMagnetic resonance imaging studySignal taskResonance imaging studyFunctional magnetic resonance imaging studyMiddle frontal gyrusTrier Social Stress TestControl conditionSignal reaction timeAftermath of stressSocial Stress TestImaging studiesCognitive functionDynamic causal modelingStress exposureEnhanced response inhibitionPilot studyFrontal gyrusLife stressNeural mechanismsStriatumResponse inhibitionNeural correlatesImmediate effects
2018
Structural and functional cerebral bases of diminished inhibitory control during healthy aging
Hu S, Ide JS, Chao HH, Castagna B, Fischer KA, Zhang S, Li C. Structural and functional cerebral bases of diminished inhibitory control during healthy aging. Human Brain Mapping 2018, 39: 5085-5096. PMID: 30113124, PMCID: PMC6287913, DOI: 10.1002/hbm.24347.Peer-Reviewed Original ResearchConceptsProlonged stop signal reaction timeStop-signal reaction timeAge-related reductionInhibitory controlFunctional changesPrefrontal cortexAge-related diminutionSignal taskRight dorsolateral prefrontal cortexSame brain regionsFunctional magnetic resonance imagingMagnetic resonance imagingMedial prefrontal cortexInferior parietal cortexResponse inhibitionDorsolateral prefrontal cortexInferior frontal cortexDiminished inhibitory controlCerebral changesStructure-function associationsSignal reaction timeCaudate headAge-related differencesStop-signal taskFrontal cortexMotor Preparation Disrupts Proactive Control in the Stop Signal Task
Wang W, Hu S, Ide JS, Zhornitsky S, Zhang S, Yu AJ, Li CR. Motor Preparation Disrupts Proactive Control in the Stop Signal Task. Frontiers In Human Neuroscience 2018, 12: 151. PMID: 29780308, PMCID: PMC5945807, DOI: 10.3389/fnhum.2018.00151.Peer-Reviewed Original ResearchStop-signal taskGranger causal connectivityMotor preparationSignal taskMotor preparatory activityFP activationCausal connectivityMotor responseTrial reaction timeDirect neural evidenceConflict anticipationBrain activationTrialsSequential effectsSuccess rateRegional activationResponse slowingActivationPreparatory activityCertain individualsDifferent patternsHigh levelsControlSlowingNeural evidenceTime scale properties of task and resting-state functional connectivity: Detrended partial cross-correlation analysis
Ide JS, Li CR. Time scale properties of task and resting-state functional connectivity: Detrended partial cross-correlation analysis. NeuroImage 2018, 173: 240-248. PMID: 29454934, PMCID: PMC5911227, DOI: 10.1016/j.neuroimage.2018.02.029.Peer-Reviewed Original ResearchConceptsDefault mode networkResting-state functional connectivityPre-supplementary motor areaPrefrontal cortical structuresFunctional connectivity analysisFunctional connectivity measuresSignal reaction timeMotor areaBrain regionsBrain functionFunctional connectivityBarratt impulsivityCortical structuresInterest analysisLow-frequency fluctuationsMode networkBOLD signalSignal taskBrain networksConnectivity analysisConnectivity measuresFMRI dataRestPrevious studies
2017
Distinct neural processes support post-success and post-error slowing in the stop signal task
Zhang Y, Ide JS, Zhang S, Hu S, Valchev NS, Tang X, Li CR. Distinct neural processes support post-success and post-error slowing in the stop signal task. Neuroscience 2017, 357: 273-284. PMID: 28627420, PMCID: PMC6359720, DOI: 10.1016/j.neuroscience.2017.06.011.Peer-Reviewed Original Research
2016
The Right Superior Frontal Gyrus and Individual Variation in Proactive Control of Impulsive Response
Hu S, Ide JS, Zhang S, Li CR. The Right Superior Frontal Gyrus and Individual Variation in Proactive Control of Impulsive Response. Journal Of Neuroscience 2016, 36: 12688-12696. PMID: 27974616, PMCID: PMC5157110, DOI: 10.1523/jneurosci.1175-16.2016.Peer-Reviewed Original ResearchConceptsStop-signal reaction timeRight superior frontal gyrusSuperior frontal gyrusConflict anticipationProactive controlFrontal gyrusImpulsive responsesCognitive controlSignal taskInhibitory controlImpulse controlRegional activationEfficient response inhibitionReaction time differencesMotor urgencyVentromedial prefrontal cortexStop-signal taskYoung adultsSignal reaction timePosterior cingulate cortexIndividual variationError RTAction restraintNeural basisResponse inhibitionNovelty Seeking, Harm Avoidance, and Cerebral Responses to Conflict Anticipation: An Exploratory Study
Hu J, Hu S, Maisano JR, Chao HH, Zhang S, Li CR. Novelty Seeking, Harm Avoidance, and Cerebral Responses to Conflict Anticipation: An Exploratory Study. Frontiers In Human Neuroscience 2016, 10: 546. PMID: 27857686, PMCID: PMC5093128, DOI: 10.3389/fnhum.2016.00546.Peer-Reviewed Original ResearchInferior parietal lobuleConflict anticipationProactive controlLateral orbitofrontal cortexMiddle frontal gyrusHarm avoidancePre-supplementary motor areaBilateral inferior parietal lobuleRight inferior parietal lobuleCognitive control circuitsWhole-brain linear regressionTrial reaction timeStop-signal taskRegional brain activationRight lateral orbitofrontal cortexCerebral responsesIndividual differencesSignal taskBrain activationFMRI studyTridimensional Personality QuestionnaireFrontal gyrusGreater activationHA traitExploratory studyA dual but asymmetric role of the dorsal anterior cingulate cortex in response inhibition and switching from a non-salient to salient action
Manza P, Hu S, Chao HH, Zhang S, Leung HC, Li CS. A dual but asymmetric role of the dorsal anterior cingulate cortex in response inhibition and switching from a non-salient to salient action. NeuroImage 2016, 134: 466-474. PMID: 27126003, PMCID: PMC4912860, DOI: 10.1016/j.neuroimage.2016.04.055.Peer-Reviewed Original ResearchConceptsDorsal anterior cingulate cortexStop-signal reaction timeAnterior cingulate cortexSignal reaction timeCingulate cortexResponse inhibitionMotor inhibitionPre-supplementary motor areaRegional activationPre-SMA functionRegional brain activationMotor response inhibitionMotor areaStop trialsSalience processingBrain activationSalience detectionSuccess trialsSignal taskTrialsInhibitionSuccessful inhibitionInfrequent stimuliCortexActivationPower spectrum scale invariance as a neural marker of cocaine misuse and altered cognitive control
Ide JS, Hu S, Zhang S, Mujica-Parodi LR, Li CS. Power spectrum scale invariance as a neural marker of cocaine misuse and altered cognitive control. NeuroImage Clinical 2016, 11: 349-356. PMID: 27294029, PMCID: PMC4888196, DOI: 10.1016/j.nicl.2016.03.004.Peer-Reviewed Original ResearchConceptsPower spectrum scale invarianceCognitive controlInferior frontal gyrusNeural markersBehavioral adjustmentSupramarginal gyrusLeft inferior frontal gyrusFunctional magnetic resonance imagingFronto-parietal areasBlood oxygenation level-dependent (BOLD) signalCocaine misuseLevel-dependent signalCocaine-dependent adultsSignal taskFrontal gyrusFrontoparietal regionsPrefrontal cortexMagnetic resonance imagingConnectivity dynamicsBehavioral variablesCerebral activityCocaine addictionCocaine exposureCocaine dependenceDependent adults
2015
Independent component analysis of functional networks for response inhibition: Inter‐subject variation in stop signal reaction time
Zhang S, Tsai S, Hu S, Xu J, Chao HH, Calhoun VD, Li C. Independent component analysis of functional networks for response inhibition: Inter‐subject variation in stop signal reaction time. Human Brain Mapping 2015, 36: 3289-3302. PMID: 26089095, PMCID: PMC4545723, DOI: 10.1002/hbm.22819.Peer-Reviewed Original ResearchConceptsStop-signal reaction timeStop-signal taskCognitive controlSignal reaction timeResponse inhibitionStop successBeta weightsReaction timeCritical executive functionFunctional networksIndependent component analysisExecutive functionError trialsSignal taskComponent processesMotor preparationBrain networksBehavioral validityMotor regionsRace modelLinear modelingGeneral linear modelingLarge sampleIndependent componentsFMRIAnticipating conflict: Neural correlates of a Bayesian belief and its motor consequence
Hu S, Ide JS, Zhang S, Li CS. Anticipating conflict: Neural correlates of a Bayesian belief and its motor consequence. NeuroImage 2015, 119: 286-295. PMID: 26095091, PMCID: PMC4564311, DOI: 10.1016/j.neuroimage.2015.06.032.Peer-Reviewed Original ResearchConceptsProactive controlMedial prefrontal cortexNeural correlatesPrefrontal cortexPre-supplementary motor areaTrial reaction timeStop-signal taskBilateral anterior insulaProlonged response timeReaction timeMotor consequencesCognitive controlConflict anticipationRT slowingSignal taskAnterior insulaTarget onsetLarge fMRI data setsPrediction errorBehavioral paradigmsBehavioral consequencesGranger causality analysisFMRI data setsBayesian beliefFMRI signalsBarratt Impulsivity and Neural Regulation of Physiological Arousal
Zhang S, Hu S, Hu J, Wu PL, Chao HH, Li CS. Barratt Impulsivity and Neural Regulation of Physiological Arousal. PLOS ONE 2015, 10: e0129139. PMID: 26079873, PMCID: PMC4469608, DOI: 10.1371/journal.pone.0129139.Peer-Reviewed Original ResearchConceptsSkin conductance responsesImpulsive individualsNeural basisPhysiological arousalArousal regulationHigh impulsivityBarratt impulsivitySkin conductanceGreater skin conductance responsesFunctional magnetic resonance imagingVentromedial prefrontal cortexStop-signal taskTheory of personalityBarratt Impulsivity ScalePoor impulse controlVmPFC activitySalient stimuliExternal stimulationImpulsive womenNeural processesNeural substratesSignal taskConductance responsesImpulsivity ScaleImpulsivityIndividual variation in the neural processes of motor decisions in the stop signal task: the influence of novelty seeking and harm avoidance personality traits
Hu J, Lee D, Hu S, Zhang S, Chao H, Li CS. Individual variation in the neural processes of motor decisions in the stop signal task: the influence of novelty seeking and harm avoidance personality traits. Brain Structure And Function 2015, 221: 2607-2618. PMID: 25989852, PMCID: PMC4654717, DOI: 10.1007/s00429-015-1061-4.Peer-Reviewed Original ResearchConceptsStop-signal taskHarm avoidanceNeural processesSignal taskPersonality traitsStudy of cognitionWhole-brain regressionRegional brain activationRisk-taking processesCognitive controlExecutive controlStop errorBrain activationFMRI studyBehavioral tasksMotor decisionsFrontopolar cortexMonetary rewardsNovelty seekingRisk-taking responsesBilateral orbitofrontalExplicit manipulationDorsomedial prefrontalRegional activationParahippocampal gyrusConflict anticipation in alcohol dependence — A model-based fMRI study of stop signal task
Hu S, Ide JS, Zhang S, Sinha R, Li CS. Conflict anticipation in alcohol dependence — A model-based fMRI study of stop signal task. NeuroImage Clinical 2015, 8: 39-50. PMID: 26106526, PMCID: PMC4473266, DOI: 10.1016/j.nicl.2015.03.008.Peer-Reviewed Original ResearchConceptsStop-signal reaction timeHealthy control individualsConflict anticipationAlcohol dependenceCognitive controlProactive controlSignal taskSequential effectsModel-based fMRI studyAlcohol consumptionStop signalPre-supplementary motor areaBilateral inferior parietal cortexPerigenual anterior cingulate cortexSignificant sequential effectInferior parietal cortexSignal reaction timeWhole-brain responsesAnterior cingulate cortexRecent alcohol consumptionNeural correlatesFMRI studyNeural markersMotor areaTrial onset
2014
Event-Related Potentials for Post-Error and Post-Conflict Slowing
Chang A, Chen CC, Li HH, Li CS. Event-Related Potentials for Post-Error and Post-Conflict Slowing. PLOS ONE 2014, 9: e99909. PMID: 24932780, PMCID: PMC4059667, DOI: 10.1371/journal.pone.0099909.Peer-Reviewed Original ResearchConceptsPost-error slowingPost-conflict slowingError-related negativityEvent-related potentialsStop-signal taskReaction time taskYoung adult participantsAmplitude of N2Cognitive controlCognitive mechanismsNeural correlatesError trialsSignal taskTime taskNeural responsesPost errorsAdult participantsParticipants' awarenessPeak latencyTaskSlowingNegativityAwarenessParticipantsCorrelatesCognitive Control in Opioid Dependence and Methadone Maintenance Treatment
Liao DL, Huang CY, Hu S, Fang SC, Wu CS, Chen WT, Lee TS, Chen PC, Li CS. Cognitive Control in Opioid Dependence and Methadone Maintenance Treatment. PLOS ONE 2014, 9: e94589. PMID: 24727743, PMCID: PMC3984179, DOI: 10.1371/journal.pone.0094589.Peer-Reviewed Original ResearchConceptsMethadone maintenance treatmentOpioid dependencePost-error slowingStop-signal reaction timePsychiatric comorbidityMaintenance treatmentCognitive controlAbstinence durationOpioid-dependent individualsResponse inhibitionHealthy control participantsMethadone treatmentSignal reaction timeCognitive dysfunctionMMT groupPsychiatric clinicSubstance misuseLonger abstinenceComorbiditiesHC participantsControl participantsDependent individualsSignal taskBehavioral adjustmentPublic health
2013
Neural bases of individual variation in decision time
Hu S, Tseng Y, Winkler AD, Li C. Neural bases of individual variation in decision time. Human Brain Mapping 2013, 35: 2531-2542. PMID: 24027122, PMCID: PMC4511156, DOI: 10.1002/hbm.22347.Peer-Reviewed Original ResearchConceptsStop-signal reaction timeSupplementary motor areaNeural basisSignal taskMovement timeTrial reaction timeStop-signal taskSignal reaction timeCaudate headReaction timeCognitive controlResponse inhibitionResponse selectionIndividual variationAccumulator modelBehavioral performanceComponent processesDecision timeLonger movement timesHuman behaviorMotor areaSimple taskBrain imagingSuccessful goTaskError processing and gender-shared and -specific neural predictors of relapse in cocaine dependence
Luo X, Zhang S, Hu S, Bednarski SR, Erdman E, Farr OM, Hong KI, Sinha R, Mazure CM, Li CS. Error processing and gender-shared and -specific neural predictors of relapse in cocaine dependence. Brain 2013, 136: 1231-1244. PMID: 23485852, PMCID: PMC3613717, DOI: 10.1093/brain/awt040.Peer-Reviewed Original ResearchConceptsDorsal anterior cingulate cortexFunctional magnetic resonance imagingCognitive controlError-related activationError processingCocaine-dependent individualsAnterior cingulate cortexSignal taskCingulate cortexCocaine dependenceFunctional magnetic resonance imaging (fMRI) dataStop-signal taskTreatment-seeking individualsCross-sectional findingsModerate-sized cohortsBrain activationBehavioral treatmentNeural predictorsDrug useMagnetic resonance imaging dataStatistical Parametric Mapping 8Regional activationPsychosocial factorsSuccess trialsMagnetic resonance imaging
2012
Saliency Processing and Obesity: A Preliminary Imaging Study of the Stop Signal Task
Hendrick OM, Luo X, Zhang S, Li C. Saliency Processing and Obesity: A Preliminary Imaging Study of the Stop Signal Task. Obesity 2012, 20: 1796-1802. PMID: 21720427, PMCID: PMC3653271, DOI: 10.1038/oby.2011.180.Peer-Reviewed Original ResearchConceptsStop-signal taskObese femalesBrain activationCognitive controlAltered cerebral functionSupplementary motor areaSignal taskRegional brain activationInferior parietal cortexSaliency processingCerebral functionLean femalesMotor areaFunctional magnetic resonance imagesParietal cortexSimilar behavioral performanceImaging studiesStop trialsPreliminary imaging studyObesityMagnetic resonance imagesTrialsGreater activationResonance imagesResponse inhibition