2025
Phenome-wide association studies between SERINC2 and neuropsychiatric disorders
Liu P, Luo X, Cao L, Zhang Y, Ji J, Wang X, Wang K, Pan X, Yang R, Tan Z, Tan Y, Li C, Guo X, Wang Z, Luo X. Phenome-wide association studies between SERINC2 and neuropsychiatric disorders. Frontiers In Psychiatry 2025, 15: 1420395. DOI: 10.3389/fpsyt.2024.1420395.Peer-Reviewed Original ResearchGray matter volumeBipolar disorderNeuropsychiatric disordersDisease-risk alleleSubcortical gray matter volumesSubstance use disordersMRNA expressionCortical surface areaAssociated with alcoholCocaine dependenceMarijuana dependencePolysubstance dependenceMatter volumeNicotine dependenceBrain regionsSchizophreniaSubcortical structuresSNP-disease associationsPhenome-wide association studyAutismOCDFDR correctionDisordersRegulatory effectsAssociation studies
2016
Associations of rare nicotinic cholinergic receptor gene variants to nicotine and alcohol dependence
Zuo L, Tan Y, Li C, Wang Z, Wang K, Zhang X, Lin X, Chen X, Zhong C, Wang X, Wang J, Lu L, Luo X. Associations of rare nicotinic cholinergic receptor gene variants to nicotine and alcohol dependence. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2016, 171: 1057-1071. PMID: 27473937, PMCID: PMC5587505, DOI: 10.1002/ajmg.b.32476.Peer-Reviewed Original ResearchMeSH KeywordsAlcoholismAnimalsBlack or African AmericanCase-Control StudiesDatabases, Nucleic AcidFemaleGene FrequencyGenetic Predisposition to DiseaseGenetic VariationGenome-Wide Association StudyHumansMaleMiceNicotinePolymorphism, Single NucleotideReceptors, NicotinicTobacco Use DisorderWhite PeopleConceptsCHRN genesGenomic regionsNicotine dependenceAD risk genesAlcohol dependenceRare variantsNicotinic cholinergic receptor genesRewarding effectsDistinct subunitsMouse brainGenesMicroarray platformRisk genesNicotine's rewarding effectsCholinergic receptor genesReceptor geneSpecific brain areasDifferent neuropsychiatric disordersIndependent cohortDiscrete regionsWhole mouse brainBrain areasNeuropsychiatric disordersMRNA expressionBrain
2012
Genome‐Wide Significant Association Signals in IPO11‐HTR1A Region Specific for Alcohol and Nicotine Codependence
Zuo L, Zhang X, Wang F, Li C, Lu L, Ye L, Zhang H, Krystal JH, Deng H, Luo X. Genome‐Wide Significant Association Signals in IPO11‐HTR1A Region Specific for Alcohol and Nicotine Codependence. Alcohol Clinical And Experimental Research 2012, 37: 730-739. PMID: 23216389, PMCID: PMC3610804, DOI: 10.1111/acer.12032.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcoholismBeta KaryopherinsBlack or African AmericanCase-Control StudiesChromosomes, Human, Pair 5FemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansMaleMiddle AgedPolymorphism, Single NucleotideQuantitative Trait LociReceptor, Serotonin, 5-HT1ATobacco Use DisorderWhite PeopleConceptsGenome-wide significance levelSingle nucleotide polymorphismsReplication cohortDiscovery cohortAlcohol dependenceExpression quantitative loci (eQTL) analysisPeripheral blood mononuclear cell samplesNeuropsychiatric disordersWide significant association signalsMononuclear cell samplesGenome-wide association studiesQuantitative loci analysisGene-disease association analysisCis-eQTL analysisTop single nucleotide polymorphismsCis-acting regulatory effectsSignificant association signalsBrain tissue samplesAmerican controlsEuropean American controlsRisk single nucleotide polymorphismsAfrican-American controlsSevere subtypeGenomic regionsAfrican American cases