2023
The effects of age on the severity of problem drinking: Mediating effects of positive alcohol expectancy and neural correlates
Chaudhary S, Chen Y, Zhornitsky S, Le T, Zhang S, Chao H, Dominguez J, Li C. The effects of age on the severity of problem drinking: Mediating effects of positive alcohol expectancy and neural correlates. Addiction Biology 2023, 28: e13278. PMID: 37252876, DOI: 10.1111/adb.13278.Peer-Reviewed Original ResearchConceptsPositive alcohol expectanciesAlcohol Use Disorders Identification TestAlcohol expectanciesAlcohol use disorderNeural correlatesCue responsesPath analysisProblem drinkingAlcohol misuseEffect of ageAUDIT scoresRostral anterior cingulate cortexWhole-brain regressionAlcohol cue exposureMiddle occipital cortexModerate alcohol use disorderAlcohol Expectancy QuestionnaireAnterior cingulate cortexAlcohol use severityBilateral rostral anterior cingulate cortexPsychological mechanismsBilateral parahippocampal gyrusCue exposureNeural processesSeverity of problems
2022
Win and Loss Responses in the Monetary Incentive Delay Task Mediate the Link between Depression and Problem Drinking
Chen Y, Dhingra I, Le T, Zhornitsky S, Zhang S, Li C. Win and Loss Responses in the Monetary Incentive Delay Task Mediate the Link between Depression and Problem Drinking. Brain Sciences 2022, 12: 1689. PMID: 36552149, PMCID: PMC9775947, DOI: 10.3390/brainsci12121689.Peer-Reviewed Original ResearchSuperior temporal gyrusMonetary incentive delay taskAlcohol Use Disorders Identification TestParahippocampal gyrusAlcohol misuseNeural correlatesReward processingWhole-brain regressionAltered reward processingIncentive delay taskDepression InventoryBDI-II scoresRight parahippocampal gyrusAlcohol use disorderDelay taskDisorders Identification TestLoss processingTemporal gyrusFrontoparietal regionsNeural markersBeck Depression InventoryDrinking adultsMediation analysisProblem drinkingSeverity of drinking
2021
Cognitive dysfunction and cerebral volumetric deficits in individuals with Alzheimer's disease, alcohol use disorder, and dual diagnosis
Zhornitsky S, Chaudhary S, Le TM, Chen Y, Zhang S, Potvin S, Chao HH, van Dyck CH, Li CR. Cognitive dysfunction and cerebral volumetric deficits in individuals with Alzheimer's disease, alcohol use disorder, and dual diagnosis. Psychiatry Research Neuroimaging 2021, 317: 111380. PMID: 34482052, PMCID: PMC8579376, DOI: 10.1016/j.pscychresns.2021.111380.Peer-Reviewed Original ResearchConceptsAlcohol use disorderAlzheimer's diseaseHippocampal formationUse disordersHigher Clinical Dementia Rating Scale-SumVentricular volumeVolumetric deficitsCingulate cortexClinical Dementia Rating Scale SumCoordinating CenterSmaller hippocampal volumesLarger ventricular volumesNational Alzheimer's Coordinating CenterIsthmus cingulate cortexPosterior cingulate cortexMisuse of alcoholSuperior parietal cortexDistinct brain regionsCognitive dysfunctionHippocampal volumeInferior frontal gyrusRegional GMVHigh riskDementia severityDual diagnosisA Multimodal Mobile Sleep Intervention for Young Adults Engaged in Risky Drinking: Protocol for a Randomized Controlled Trial (Preprint)
Fucito LM, Ash GI, DeMartini KS, Pittman B, Barnett NP, Li CR, Redeker NS, O'Malley SS. A Multimodal Mobile Sleep Intervention for Young Adults Engaged in Risky Drinking: Protocol for a Randomized Controlled Trial (Preprint). JMIR Research Protocols 2021, 10: e26557. PMID: 33635276, PMCID: PMC7954653, DOI: 10.2196/26557.Peer-Reviewed Original ResearchSleep hygiene adviceINTERNATIONAL REGISTERED REPORT IDENTIFIERHeavy-drinking young adultsHygiene adviceSleep interventionsYoung adultsAlcohol diaryAlcohol use disorder riskRisky alcohol consumptionAlcohol use disorderLow-cost interventionAlcohol behavior changeControlled TrialsWeb-based sessionsBrief adviceHealth coachesRisk factorsPoor sleepRecent heavy drinkingSleep characteristicsUse disordersAlcohol consumptionAlcohol-related consequencesPriority populationsSecondary aim
2018
Mega-Analysis of Gray Matter Volume in Substance Dependence: General and Substance-Specific Regional Effects
Mackey S, Allgaier N, Chaarani B, Spechler P, Orr C, Bunn J, Allen NB, Alia-Klein N, Batalla A, Blaine S, Brooks S, Caparelli E, Chye YY, Cousijn J, Dagher A, Desrivieres S, Feldstein-Ewing S, Foxe JJ, Goldstein RZ, Goudriaan AE, Heitzeg MM, Hester R, Hutchison K, Korucuoglu O, Li CR, London E, Lorenzetti V, Luijten M, Martin-Santos R, May A, Momenan R, Morales A, Paulus MP, Pearlson G, Rousseau ME, Salmeron BJ, Schluter R, Schmaal L, Schumann G, Sjoerds Z, Stein DJ, Stein EA, Sinha R, Solowij N, Tapert S, Uhlmann A, Veltman D, van Holst R, Whittle S, Wiers R, Wright M, Yücel M, Zhang S, Yurgelun-Todd D, Hibar D, Jahanshad N, Evans A, Thompson P, Glahn D, Conrod P, Garavan H. Mega-Analysis of Gray Matter Volume in Substance Dependence: General and Substance-Specific Regional Effects. American Journal Of Psychiatry 2018, 176: 119-128. PMID: 30336705, PMCID: PMC6427822, DOI: 10.1176/appi.ajp.2018.17040415.Peer-Reviewed Original ResearchConceptsRegional brain volumesControl subjectsSubstance dependenceBrain volumeBrain regionsLower brain volumeAlcohol use disorderGray matter volumeTotal intracranial volumeMedial orbitofrontal cortexCommon neural substrateCortical thicknessUse disordersUseful biomarkerMatter volumeSubcortical volumesImaging biomarkersAlcohol dependenceIntracranial volumeOrbitofrontal cortexRegional volumesBrain structuresRelevant imaging biomarkersLow volumeNeural substrates