Carly Therese Thaxton, MD
Hospital ResidentCards
About
Research
Publications
2026
Variation in Management of Blunt Splenic Injury by Trauma Center Training Status.
Hellmann Z, Sohi G, Thaxton C, Jones A, Christison-Lagay E, Solomon D. Variation in Management of Blunt Splenic Injury by Trauma Center Training Status. Journal Of The American College Of Surgeons 2026, 242: 1498-1504. PMID: 41562442, DOI: 10.1097/xcs.0000000000001779.Peer-Reviewed Original ResearchBlunt splenic injuryNon-operative managementManagement of blunt splenic injuryPediatric Health Information SystemSplenic injuryInjury Severity ScoreSurgical managementPatient demographicsNon-operative management of blunt splenic injuryFailure of non-operative managementPediatric blunt splenic injuryPercutaneous endovascular embolizationSevere splenic injuriesPediatric trauma surgeonICD-10 diagnostic codesHealth information systemsInjury severityMultivariate logistic regressionRates of interventionSplenic interventionEndovascular embolizationFellowship training programsSurgical fellowshipsSurgical interventionInterinstitutional variability
2025
A declining incidence of gastroschisis parallels trends in maternal smoking rates in the United States
Hellmann Z, Haynes C, Fortoul M, Thaxton C, Buu L, Solomon D, Cowles R. A declining incidence of gastroschisis parallels trends in maternal smoking rates in the United States. Journal Of Pediatric Surgery 2025, 61: 162861. PMID: 41349788, DOI: 10.1016/j.jpedsurg.2025.162861.Peer-Reviewed Original ResearchMaternal smoking ratesSmoking ratesLive birthsGastroschisis rateMaternal smokingDeclining incidenceDiagnosis of gastroschisisIncidence of gastroschisisNumbers of cigarettesDepartment of HealthDaily numberUnited StatesGastroschisisPrimary outcomeRisk factorsNewbornsBirthSmokingYoung adultsDiagnosisMothersIndependent variablesConcurrent decreasePregnancyComplete informationTurbulence drives arteriovenous remodeling: an experimentally validated multi-scale model of neointimal hyperplasia
Varsanik M, Thaxton C, Nguyen D, Pugar J, Dhara S, Li W, Nguyen N, Dardik A, Pocivavsek L. Turbulence drives arteriovenous remodeling: an experimentally validated multi-scale model of neointimal hyperplasia. Physics In Medicine And Biology 2025, 70: 10.1088/1361-6560/ae1ac8. PMID: 41183446, PMCID: PMC12915627, DOI: 10.1088/1361-6560/ae1ac8.Peer-Reviewed Original ResearchConceptsComputational fluid dynamicsTurbulence intensityMulti-scale modelComputational fluid dynamics resultsComputational fluid dynamics simulationsBoundary conditionsFluid dynamicsFluid domainArteriovenous fistulaThickness gradientVelocity measurementsTurbulenceNeointimal hyperplasiaInput parametersLong-term dialysis accessThrombus depositionProliferation of vascular smooth muscle cellsArteriovenous fistula creationEnd stage renal patientsVascular smooth muscle cellsFrequent clinical problemVenous outflow stenosisSmooth muscle cellsPost-AVF creationVelocityArnold Schwarzenegger or Danny DeVito? The fate of twins with necrotizing enterocolitis in the NICU
Hellmann Z, Thaxton C, Sapir N, Rehman S, Cowles R, Christison-Lagay E, Solomon D. Arnold Schwarzenegger or Danny DeVito? The fate of twins with necrotizing enterocolitis in the NICU. Journal Of Pediatric Surgery 2025, 61: 162526. PMID: 40812408, DOI: 10.1016/j.jpedsurg.2025.162526.Peer-Reviewed Original ResearchMultiple gestation pregnanciesGestation pregnanciesSingleton birthsUncontrolled cohortIncidence of necrotizing enterocolitisNeonatal intensive care unitDevelopment of NECIncidence of NECPediatric Health Information SystemIntensive care unitSingleton gestationsGestational ageMultiple gestationsNICU populationSingleton infantsNecrotizing enterocolitisNICU infantsLow birthweightAverage birthweightInternal validityPrimary outcomeGestationCare unitShort gestationInfantsWhy did the children cross the road? The relationship between roadway design and severe pediatric trauma in pedestrians struck by motor vehicle
Hellmann Z, Jones A, Thaxton C, Bergus K, Mansfield A, Solomon D, Mansfield S, Christison-Lagay E. Why did the children cross the road? The relationship between roadway design and severe pediatric trauma in pedestrians struck by motor vehicle. Journal Of Pediatric Surgery 2025, 61: 162522. PMID: 40812397, DOI: 10.1016/j.jpedsurg.2025.162522.Peer-Reviewed Original ResearchInjury Severity ScorePediatric pedestriansSchool zonesIntersection densityMotor vehiclesICD-10 diagnostic codesRoadway designMultivariable Poisson regressionLower Injury Severity ScoreWalking IndexSevere pediatric traumaOhio DepartmentSeverity of injuryPoisson regressionDiagnostic codesCensus tractsPediatric traumaICD-10Children's HospitalPediatric hospitalPrimary outcomeSlow trafficSpeed limitDriving speedSeverity scorePrevalence of Critical Congenital Heart Defects Among Neonates Born With Abdominal Wall Defects
Hellmann Z, Buu L, Rehman S, Thaxton C, Solomon D, Cowles R. Prevalence of Critical Congenital Heart Defects Among Neonates Born With Abdominal Wall Defects. Prenatal Diagnosis 2025, 45: 1115-1121. PMID: 40670328, DOI: 10.1002/pd.6861.Peer-Reviewed Original ResearchConceptsCritical congenital heart defectsNeonatal intensive care unitPediatric Health Information SystemNeonatal intensive care unit admissionCongenital heart defectsOpen cardiac surgeryCardiac surgeryHeart defectsConcomitant diagnosisNeonatal intensive care unit populationPediatric Health Information System hospitalsDiagnosis of gastroschisisGeneral populationIntensive care unitRate of gastroschisisAbdominal wall defectsIndex hospital admissionHigher RatesLive birthsGastroschisisCare unitNeonatesWall defectsHospital admissionAdmissionAtypical presentation of occult congenital diaphragmatic hernia as intermittent obstructive symptoms: A case report
Haynes C, Thaxton C, Shaughnessy M, Stitelman D. Atypical presentation of occult congenital diaphragmatic hernia as intermittent obstructive symptoms: A case report. Journal Of Pediatric Surgery Case Reports 2025, 117: 103018. DOI: 10.1016/j.epsc.2025.103018.Peer-Reviewed Original ResearchCongenital diaphragmatic herniaLate-onset congenital diaphragmatic herniaDiaphragmatic herniaObstructive symptomsAbdominal painDifferential diagnosis of childrenIntermittent obstructive symptomsNormal stooling patternObstructive bowel symptomsRightward mediastinal shiftPost-operative courseFive-month historyNormal bowel movementsAcute respiratory distressMonths of lifeAcute intestinal obstructionDiagnosis of childrenPrenatal suspicionBands of scar tissueAtypical presentationCongenital anomaliesStool patternMediastinal shiftBowel obstructionFibrotic bandsSustained tenascin-C expression drives neointimal hyperplasia and promotes aortocaval fistula failure
Gonzalez L, Zhang W, Bai H, Taniguchi R, Ramachandra A, Jovin D, Ohashi Y, Nguyen M, Thaxton C, Yatsula B, Vazquez-Padron R, Humphrey J, Martin K, Kyriakides T, Dardik A. Sustained tenascin-C expression drives neointimal hyperplasia and promotes aortocaval fistula failure. AJP Heart And Circulatory Physiology 2025, 328: h1147-h1167. PMID: 40247455, PMCID: PMC12150301, DOI: 10.1152/ajpheart.00661.2024.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArteriovenous Shunt, SurgicalDisease Models, AnimalGraft Occlusion, VascularHuman Umbilical Vein Endothelial CellsHumansHyperplasiaMacrophagesMaleMiceMice, Inbred C57BLMice, KnockoutMyocytes, Smooth MuscleNeointimaNF-kappa BTenascinThrombomodulinVascular PatencyVascular RemodelingVena Cava, InferiorConceptsArteriovenous fistula patencyTenascin-C expressionArteriovenous fistulaTissue factor expressionEnd-stage kidney diseaseAnti-inflammatory macrophage polarizationNeointimal hyperplasiaWT miceTenascin-CInflammatory microenvironmentWild-typeFactor expressionMacrophage polarizationArteriovenous fistula outcomesArteriovenous fistula failurePatent arteriovenous fistulaVein smooth muscle cellsArteriovenous fistula maturationSmooth muscle cellsOccluded arteriovenous fistulaHuman umbilical vein smooth muscle cellsImprove dialysis outcomesHuman umbilical vein endothelial cellsRegulation of inflammationNF-kB activationChapter 2 Etiology, risk factors, and pathophysiology of carotid artery stenosis
Thaxton C, Dardik A. Chapter 2 Etiology, risk factors, and pathophysiology of carotid artery stenosis. 2025, 11-24. DOI: 10.1016/b978-0-443-13865-2.00005-6.Chapters
2024
Endothelial TGF-β Signaling Regulates Endothelial-Mesenchymal Transition During Arteriovenous Fistula Remodeling in Mice With Chronic Kidney Disease
Zhang W, Gonzalez L, Li X, Bai H, Li Z, Taniguchi R, Langford J, Ohashi Y, Thaxton C, Aoyagi Y, Yatsula B, Martin K, Goodwin J, Tellides G, Long X, Shu C, Dardik A. Endothelial TGF-β Signaling Regulates Endothelial-Mesenchymal Transition During Arteriovenous Fistula Remodeling in Mice With Chronic Kidney Disease. Arteriosclerosis Thrombosis And Vascular Biology 2024, 44: 2509-2526. PMID: 39297205, PMCID: PMC11593991, DOI: 10.1161/atvbaha.124.320933.Peer-Reviewed Original ResearchChronic kidney diseaseTGF-b signalingArteriovenous fistula patencyArteriovenous fistulaKidney diseaseAVF patencyEndothelial cellsAssociated with endothelial injuryArteriovenous fistula diameterImprove AVF patencyIncreased outward remodelingReduced patencyInduced endothelial-to-mesenchymal transitionAortocaval fistula modelSmooth muscle cell proliferationArteriovenous fistula failureAttenuated EndMTEnd-stage kidney diseaseHuman arteriovenous fistulaeSmooth muscle cellsMuscle cell proliferationEndothelial-to-mesenchymal transitionMouse endothelial cellsInhibition of EndMTEndothelial-mesenchymal transition