Brandon Lee, MD/PhD
Clinical FellowDownloadHi-Res Photo
About
Titles
Clinical Fellow
Biography
Dr. Brandon Lee completed his MD and PhD in Immunology at the University of Chicago. He conducted his research with Dr. Juliane Bubeck Wardenburg and showed that Staphylococcus aureus hemolysin-alpha expression suppressed the formation of T cell memory and cytokine production during skin infection, impeding the development of protective, adaptive immunity to S. aureus infection. His research interests are focused on host-microbe communication and interactions; specifically, how microbes may interpret and adapt to signaling by the host immune response.
Appointments
Departments & Organizations
Education & Training
- MD/PhD
- University of Chicago, Immunology (2020)
- BA
- University of Chicago, Chemistry (2011)
Research
Publications
2022
Enterococcus faecalis promotes a migratory and invasive phenotype in colon cancer cells
Williamson AJ, Jacobson R, van Praagh JB, Gaines S, Koo HY, Lee B, Chan WC, Weichselbaum R, Alverdy JC, Zaborina O, Shogan BD. Enterococcus faecalis promotes a migratory and invasive phenotype in colon cancer cells. Neoplasia 2022, 27: 100787. PMID: 35366466, PMCID: PMC8971311, DOI: 10.1016/j.neo.2022.100787.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsE. faecalisTumor progressionCollagenolytic bacteriaPost-surgical recoveryHuman colon cancer specimensMurine colon cancer cell lineEnterococcus faecalisColon cancer developmentColon cancer specimensColon cancer cell linesCancer cell invasionCurative resectionCancer cell linesColon cancer cellsCancer specimensMouse modelIntestinal microbesCT26 cellsCancer developmentTumor developmentCollagenase productionTumor formationCancer cellsInvasive phenotypeCell invasion
2020
Staphylococcus aureus α-toxin suppresses antigen-specific T cell responses
Lee B, Olaniyi R, Kwiecinski JM, Wardenburg JB. Staphylococcus aureus α-toxin suppresses antigen-specific T cell responses. Journal Of Clinical Investigation 2020, 130: 1122-1127. PMID: 31873074, PMCID: PMC7269593, DOI: 10.1172/jci130728.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsT cell responsesSkin infectionsCell responsesAntigen-specific T cell responsesOVA-specific T cell responsesT cell-mediated immunityS. aureusΑ-toxinAntigen-specific modelChicken egg OVACell-mediated immunityT cell memoryAntigen-specific memoryPrimary skin infectionsInvasive staphylococcal diseaseStaphylococcus aureus α-toxinDevelopment of immunityΑ-toxin expressionAureus α-toxinProtective immunityInvasive infectionsLeading causeLoss of DCsStaphylococcal diseaseLong-term protection
2018
A common approach to toxin specificity
Lee B, Bubeck Wardenburg J. A common approach to toxin specificity. Nature Microbiology 2018, 3: 644-645. PMID: 29795538, DOI: 10.1038/s41564-018-0173-z.Peer-Reviewed Original ResearchCitationsAltmetric
Academic Achievements and Community Involvement
honor AAI Young Investigator Award
National AwardDetails11/22/2013United States
Links & Media
News
- August 10, 2022
Welcome New Staff, Faculty, Fellows, Postgrads (August 2022)
- June 07, 2021
Resident Roundup: Brandon Lee
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