Arumugam Suyavaran, MSc, PhD
Associate Research ScientistCards
Appointments
Digestive Diseases
Primary
Contact Info
About
Titles
Associate Research Scientist
Appointments
Digestive Diseases
Associate Research ScientistPrimary
Other Departments & Organizations
Education & Training
- PhD
- Pondicherry University, Biochemistry and Molecular Biology (2017)
- MSc
- Pondicherry University, Biochemistry and Molecular Biology (2009)
- BSc
- JIPMER, Medical Laboratory Technology (2007)
Research
Research at a Glance
Yale Co-Authors
Frequent collaborators of Arumugam Suyavaran's published research.
Publications Timeline
A big-picture view of Arumugam Suyavaran's research output by year.
Xinshou Ouyang, PhD
Wajahat Mehal, MD, DPhil
Huabing Li, PhD
Michael H Nathanson, MD, PhD
Yasuko Iwakiri, PhD
9Publications
139Citations
Publications
Featured Publications
GSK3β mediates the spatiotemporal dynamics of NLRP3 inflammasome activation
Arumugam S, Qin Y, Liang Z, Han SN, Boodapati SLT, Li J, Lu Q, Flavell RA, Mehal WZ, Ouyang X. GSK3β mediates the spatiotemporal dynamics of NLRP3 inflammasome activation. Cell Death & Differentiation 2022, 29: 2060-2069. PMID: 35477991, PMCID: PMC9525599, DOI: 10.1038/s41418-022-00997-y.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsInflammasome assemblyGlycogen synthase kinase-3βSynthase kinase-3βOrganelle dynamicsGolgi networkSubcellular machineryGolgi apparatusInflammasome activationMechanistic basisKinase-3βMolecular determinantsSpatiotemporal dynamicsGSK3β activationMitochondriaNLRP3 oligomerizationTGNSubsequent bindingGSK3βNLRP3 inflammasome activationActivationNew avenuesAssemblyStepwise processOrganellesPhosphatidylinositolPreconditioning methods in the management of hepatic ischemia reperfusion- induced injury: Update on molecular and future perspectives.
Suyavaran A, Thirunavukkarasu C. Preconditioning methods in the management of hepatic ischemia reperfusion- induced injury: Update on molecular and future perspectives. Hepatol Res 2017, 47: 31-48. PMID: 26990696, DOI: 10.1111/hepr.12706.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statementsm6A mRNA methylation-directed myeloid cell activation controls progression of NAFLD and obesity
Qin Y, Li B, Arumugam S, Lu Q, Mankash SM, Li J, Sun B, Li J, Flavell RA, Li HB, Ouyang X. m6A mRNA methylation-directed myeloid cell activation controls progression of NAFLD and obesity. Cell Reports 2021, 37: 109968. PMID: 34758326, PMCID: PMC8667589, DOI: 10.1016/j.celrep.2021.109968.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsNon-alcoholic fatty liver diseaseProgression of NAFLDLineage-restricted deletionFatty liver diseaseMultiple mRNA transcriptsMyeloid cell activationDiet-induced developmentMethyladenosine (m<sup>6</sup>A) RNA modificationMRNA metabolismProtein methyltransferaseLiver diseaseRNA modificationsCellular stressMetabolic reprogrammingDDIT4 mRNACell activationObesityDifferential expressionMammalian targetMRNA transcriptsSignificant downregulationCytokine stimulationPathway activityMetabolic phenotypeMRNA levelsMitochondrial DNA and the STING pathway are required for hepatic stellate cell activation
Arumugam S, Li B, Boodapati S, Nathanson M, Sun B, Ouyang X, Mehal W. Mitochondrial DNA and the STING pathway are required for hepatic stellate cell activation. Hepatology 2023, 78: 1448-1461. PMID: 37013923, PMCID: PMC10804318, DOI: 10.1097/hep.0000000000000388.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsVoltage-dependent anion channelBioenergetic capacityMitochondrial DNATranscriptional upregulationCyclic GMP-AMP synthaseGMP-AMP synthaseTranscriptional regulationBioenergetic organellesFunctional mitochondriaMitochondrial membraneExternal mitochondrial membraneAnabolic pathwaysMitochondrial massAnion channelInterferon genesHSC transdifferentiationSubsequent activationCGAS-STINGTransdifferentiationIRF3 pathwayPathwaySTING pathwayGenesMitochondriaQuiescent HSCs
2019
Digoxin improves steatohepatitis with differential involvement of liver cell subsets in mice through inhibition of PKM2 transactivation
Zhao P, Han SN, Arumugam S, Yousaf MN, Qin Y, Jiang JX, Torok NJ, Chen Y, Mankash MS, Liu J, Li J, Iwakiri Y, Ouyang X. Digoxin improves steatohepatitis with differential involvement of liver cell subsets in mice through inhibition of PKM2 transactivation. AJP Gastrointestinal And Liver Physiology 2019, 317: g387-g397. PMID: 31411894, PMCID: PMC6842989, DOI: 10.1152/ajpgi.00054.2019.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsHigh-fat dietSignificant clinical applicabilityHuman nonalcoholic steatohepatitisNonalcoholic steatohepatitisOral digoxinLiver injuryCell subsetsPathway activationMouse modelHigh-fat diet mouse modelLiver injury mouse modelHepatocyte mitochondrial dysfunctionClinical applicabilityDiet mouse modelInjury mouse modelDifferential involvementLarge clinical experienceNLRP3 inflammasome activationSignificant protective effectHIF-1α transactivationHepatic oxidative stress responseHypoxia-inducible factorLiver inflammationHFD miceWide dosage rangeHematology Safety Data for the Fermented Soy Beverage Q-CAN® Plus (P12-033-19)
Mehal W, Suyavaran A, Dioletis E, Paiva R, Secor E, Weiss T, Fields M, Ouyang X, Ali A. Hematology Safety Data for the Fermented Soy Beverage Q-CAN® Plus (P12-033-19). Current Developments In Nutrition 2019, 3: 3013529. PMCID: PMC6574472, DOI: 10.1093/cdn/nzz035.p12-033-19.Peer-Reviewed Original ResearchConceptsObese individualsMean corpuscular hemoglobin concentrationMean corpuscular hemoglobinTreatment periodHematological parametersVisit 1Red blood cell distribution widthC-reactive proteinMethods Prospective studyCell distribution widthYale New Haven HealthCorpuscular hemoglobin concentrationVisit 7Clinic visitsProspective studyVisit 3Significant changesWBC countPlatelet volumeVisit 8Safety dataHematology labCorpuscular volumeHemoglobin concentrationBlood indicesReduction in Serum Levels of Inflammatory Cytokines in Subjects Consuming the Fermented Soy Beverage Q-CAN® Plus (P19-010-19)
Mehal W, Suyavaran A, Dioletis E, Paiva R, Weiss T, Fields M, Ouyang X. Reduction in Serum Levels of Inflammatory Cytokines in Subjects Consuming the Fermented Soy Beverage Q-CAN® Plus (P19-010-19). Current Developments In Nutrition 2019, 3: nzz049.p19-010-19. PMCID: PMC6579392, DOI: 10.1093/cdn/nzz049.p19-010-19.Peer-Reviewed Original ResearchCitationsConceptsObese subjectsSerum levelsInflammatory cytokinesIL-1raVisit 1Obese individualsHuman magnetic LuminexPDGF-AA levelsMethods Prospective studyKey inflammatory cytokinesAB/BBConclusion ConsumptionGMCSF levelsMagnetic LuminexVisit 7Clinic visitsCytokine levelsLean subjectsProspective studyVisit 3Visit 8Healthy subjectsMetabolic disordersTherapeutic phasePDGF-AA
2018
Neutrophil extracellular traps in acrolein promoted hepatic ischemia reperfusion injury: Therapeutic potential of NOX2 and p38MAPK inhibitors.
Arumugam S, Girish Subbiah K, Kemparaju K, Thirunavukkarasu C. Neutrophil extracellular traps in acrolein promoted hepatic ischemia reperfusion injury: Therapeutic potential of NOX2 and p38MAPK inhibitors. J Cell Physiol 2018, 233: 3244-3261. PMID: 28884828, DOI: 10.1002/jcp.26167.Peer-Reviewed Original Research
2015
TNF-α suppression by glutathione preconditioning attenuates hepatic ischemia reperfusion injury in young and aged rats.
Suyavaran A, Ramamurthy C, Mareeswaran R, Subastri A, Lokeswara Rao P, Thirunavukkarasu C. TNF-α suppression by glutathione preconditioning attenuates hepatic ischemia reperfusion injury in young and aged rats. Inflamm Res 2015, 64: 71-81. PMID: 25420731, DOI: 10.1007/s00011-014-0785-6.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
honor Presidential poster of distinction
International AwardAASLDDetails11/10/2023United Stateshonor AGA Institute Council-Gastroenterology Research Group (GRG) Basic Science Trainee Award
International AwardAmerican Gastroenterological AssociationDetails05/08/2023United States