About
Titles
Postdoctoral Fellow
Biography
Arthur Stem received his Ph.D. in Toxicology from the University of Colorado Anschutz Medical Campus. His dissertation centered on contributions of environmental toxicants to the pathogenesis of chronic kidney disease of unknown etiology. He joined the Vasilis lab in 2024 and is using his background in environmental and mechanistic toxicology to elucidate how environmental exposures influence the development of liver disease.
Last Updated on February 07, 2025.
Education & Training
- PhD
- University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Toxicology (2024)
- BS
- University of Arkansas at Little Rock, Biology (2014)
- AS
- National Park Community College, Science (2011)
Research
Publications
Featured Publications
Synergistic toxicity in alcohol-associated liver disease and PFAS exposure
Stem A, Tieghi R, Chatzi V, Kleinstreuer N, Valvi D, Thompson D, Vasiliou V. Synergistic toxicity in alcohol-associated liver disease and PFAS exposure. Toxicological Sciences 2025, kfaf110. PMID: 40737496, DOI: 10.1093/toxsci/kfaf110.Peer-Reviewed Original ResearchAlcohol-associated liver diseaseLiver diseaseChronic ethanol intakeCentral mechanismsHepatotoxic effectsPolyfluoroalkyl substancesHigh-risk populationOxidative stressDysregulated lipid metabolismEthanol intakeLiver functionLiver injuryAcetaldehyde-induced cytotoxicityHepatic functionHepatocellular damageOxidative stress inductionLiver pathologyGlobal morbidityPathogenic pathwaysPolyfluoroalkyl substances exposuresExposure to polyfluoroalkyl substancesFatty acid oxidationHealthcare accessEffects of polyfluoroalkyl substancesMultiple mechanisms
2025
Integrating gut microbiome and neuroplasticity genomics in alcohol use disorder therapy
Koutromanos I, Legaki E, Dovrolis N, Vassilopoulos E, Stem A, Vasiliou V, Tzavellas E, Gazouli M. Integrating gut microbiome and neuroplasticity genomics in alcohol use disorder therapy. Human Genomics 2025, 19: 78. PMID: 40646629, PMCID: PMC12255058, DOI: 10.1186/s40246-025-00793-y.Peer-Reviewed Original ResearchConceptsGut microbiotaShort-chain fatty acid (SCFA)-producing bacteriaMetabolic pathwaysStress-related metabolic pathwaysHost-microbiota interactionsMicrobial metabolic pathwaysMulti-omics approachGut barrier integrityGene expression changesGene expression profilesNeuroplasticity-related genesRRNA sequencingGut microbiomeFamily genesGenomic signaturesMicrobiome compositionMicrobial compositionAUD patientsMicrobial dysbiosisTreatment responseFunctional pathwaysGene expressionMicrobiomeGenesExpression changesModulation of the thiol redox proteome by sugarcane ash-derived silica nanoparticles: Insights into chronic kidney disease of unknown etiology
Stem A, Michel C, Harris P, Rogers K, Gibb M, Roncal-Jimenez C, Reisdorph R, Johnson R, Roede J, Fritz K, Brown J. Modulation of the thiol redox proteome by sugarcane ash-derived silica nanoparticles: Insights into chronic kidney disease of unknown etiology. Free Radical Biology And Medicine 2025, 233: s44. DOI: 10.1016/j.freeradbiomed.2025.05.158.Peer-Reviewed Original ResearchAdvancing translational exposomics: bridging genome, exposome and personalized medicine
Sarigiannis D, Karakitsios S, Anesti O, Stem A, Valvi D, Sumner S, Chatzi L, Snyder M, Thompson D, Vasiliou V. Advancing translational exposomics: bridging genome, exposome and personalized medicine. Human Genomics 2025, 19: 48. PMID: 40307849, PMCID: PMC12044731, DOI: 10.1186/s40246-025-00761-6.Peer-Reviewed Original ResearchConceptsExposome-wide association studyBridge genomicsLifestyle exposuresEnhancing causal inferencePublic health decision-makingEnvironmental health researchHealth decision-makingMulti-omics technologiesGenomic variationGenomic dataAssociation studiesHealth outcomesBioinformatics approachHealth researchPrecision preventionGenetic variabilityExposome dataExposure-response relationshipMulti-OmicsGenomeInternal exposomeVulnerable populationsComplex diseasesDisease phenotypePublic healthModulation of the thiol redox proteome by sugarcane ash-derived silica nanoparticles: insights into chronic kidney disease of unknown etiology
Stem A, Michel C, Harris P, Rogers K, Gibb M, Roncal-Jimenez C, Reisdorph R, Johnson R, Roede J, Fritz K, Brown J. Modulation of the thiol redox proteome by sugarcane ash-derived silica nanoparticles: insights into chronic kidney disease of unknown etiology. Particle And Fibre Toxicology 2025, 22: 3. PMID: 39910563, PMCID: PMC11800628, DOI: 10.1186/s12989-025-00619-8.Peer-Reviewed Original ResearchMeSH KeywordsBasic Helix-Loop-Helix Transcription FactorsCell LineChronic Kidney Diseases of Uncertain EtiologyHumansKidney Tubules, ProximalNanoparticlesOccupational ExposureOxidation-ReductionOxidative StressProteomeProteomicsReactive Oxygen SpeciesReceptors, Aryl HydrocarbonRenal Insufficiency, ChronicSaccharumSilicon DioxideSulfhydryl CompoundsConceptsProximal convoluted tubulesActivation of aryl hydrocarbon receptorExposure to silica nanoparticlesDisease of unknown etiologyReactive oxygen speciesKidney proximal convoluted tubuleIncreased reactive oxygen species generationChronic kidney diseaseSignaling pathwayIntroductionChronic kidney diseaseHK-2 cellsReactive oxygen species generationProfile in vitroPotential mechanisms of toxicityMembrane hyperpolarizationCKD progressionUnknown etiologyGeneration of reactive oxygen speciesMitochondrial membrane hyperpolarizationOxygen species generationAryl hydrocarbon receptorEnergy metabolismKidney diseaseConvoluted tubulesMechanisms of toxicity
2024
Response to Avoid Preclinical Errors When Using Urine Biomarkers of Exposure
Stem A, Brindley S, Rogers K, Salih A, Roncal-Jimenez C, Johnson R, Newman L, Butler-Dawson J, Krisher L, Brown J. Response to Avoid Preclinical Errors When Using Urine Biomarkers of Exposure. Kidney International Reports 2024, 10: 281-283. PMID: 39810784, PMCID: PMC11725806, DOI: 10.1016/j.ekir.2024.11.003.Peer-Reviewed Original ResearchP06-05 Exposomics analysis of agricultural workers at risk for Mesoamerican nephropathy
Stem A, Roncal C, Johnson R, Brown J. P06-05 Exposomics analysis of agricultural workers at risk for Mesoamerican nephropathy. Toxicology Letters 2024, 399: s153. DOI: 10.1016/j.toxlet.2024.07.389.Peer-Reviewed Original ResearchHealth burden of sugarcane burning on agricultural workers and nearby communities
Stem A, Gibb M, Roncal-Jimenez C, Johnson R, Brown J. Health burden of sugarcane burning on agricultural workers and nearby communities. Inhalation Toxicology 2024, 36: 327-342. PMID: 38349733, PMCID: PMC11260540, DOI: 10.1080/08958378.2024.2316875.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsExposome and Metabolome Analysis of Sugarcane Workers Reveals Predictors of Kidney Injury
Stem A, Brindley S, Rogers K, Salih A, Roncal-Jimenez C, Johnson R, Newman L, Butler-Dawson J, Krisher L, Brown J. Exposome and Metabolome Analysis of Sugarcane Workers Reveals Predictors of Kidney Injury. Kidney International Reports 2024, 9: 1458-1472. PMID: 38707825, PMCID: PMC11069010, DOI: 10.1016/j.ekir.2024.01.060.Peer-Reviewed Original ResearchKidney function declineChronic kidney diseaseKidney injuryIncreased incidence of CKDPredictor of kidney injuryKidney diseaseMetabolomic analysisIncidence of chronic kidney diseaseKidney injury marker-1Urine samplesPerturbing amino acid metabolismImpaired kidney functionInvestigate potential biomarkersRates of kidney diseaseUrine profilesKidney functionExposure to silicaIncreased incidencePotential biomarkersAmino acid metabolismUrineOccupational exposure to silicaElemental analysisMetabolomicsFunctional declineIntranasal administration of sugarcane ash causes chronic kidney disease in rats
Roncal-Jimenez C, Rogers K, Stem A, Wijkstrom J, Wernerson A, Fox J, Trabanino R, Brindley S, Garcia G, Miyazaki M, Miyazaki-Anzai S, Sasai F, Urra M, Cara-Fuentes G, Sánchez-Lozada L, Rodriguez-Iturbe B, Dawson J, Madero M, Brown J, Johnson R. Intranasal administration of sugarcane ash causes chronic kidney disease in rats. American Journal Of Physiology. Renal Physiology 2024, 326: f477-f484. PMID: 38234297, PMCID: PMC11207544, DOI: 10.1152/ajprenal.00251.2023.Peer-Reviewed Original ResearchChronic kidney diseaseKidney diseaseGroups of ratsSpleen of ratsChronic tubulointerstitial diseaseMild proteinuriaRenal functionTubulointerstitial inflammationIntranasal administrationDecreased stainingInduce CKDSegmental glomerulosclerosisKidney histologyTubulointerstitial diseaseKidney pathologyCollagen depositionRatsKidneyKidney tissueFibrosisWeeksCKDDiseaseInflammationLAMP-1
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