Antariksh Tyagi, PhD
Associate Research Scientist in GeneticsCards
Appointments
Genetics
Primary
Contact Info
Yale Center for Genome Analysis (YCGA)
830 West campus Dr
West Haven, CT 06516
United States
About
Titles
Associate Research Scientist in Genetics
Appointments
Genetics
Associate Research ScientistPrimary
Other Departments & Organizations
Education & Training
- Postdoctoral Scientist
- Kansas State University
- PhD
- CSIR-National Botanical Research Institute, India (2017)
Research
Research at a Glance
Yale Co-Authors
Frequent collaborators of Antariksh Tyagi's published research.
Publications Timeline
A big-picture view of Antariksh Tyagi's research output by year.
Bony De Kumar, PhD
Ann Haberman, PhD
Brent Vander Wyk, PhD
Brett Lindenbach, PhD
Caroline Zeiss, DACVP, DACLAM
Emanuela Bruscia, PhD
14Publications
12Citations
Publications
2024
A scalable and cost-efficient rRNA depletion approach to enrich RNAs for molecular biology investigations
Singh A, Xue A, Tai J, Mbadugha F, Obi P, Mascarenhas R, Tyagi A, Siena A, Chen Y. A scalable and cost-efficient rRNA depletion approach to enrich RNAs for molecular biology investigations. RNA 2024, 30: rna.079761.123. PMID: 38485192, PMCID: PMC11098455, DOI: 10.1261/rna.079761.123.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsDepleting rRNACellular processesAbundance of rRNAMolecular biological investigationsNon-rRNA transcriptsComplex regulatory networkInvestigate gene expressionRRNA removalRRNA moleculesHistone mRNARegulatory networksSmall RNAsPositive selectionRRNARNA inputBiological investigationsTranscriptome analysisLong noncoding RNAsGene expressionRegulatory mechanismsRNAOff-target effectsNoncoding RNAsCircular RNAsTranscriptionShort peptides based on the conserved regions of MIEN1 protein exhibit anticancer activity by targeting the MIEN1 signaling pathway.
Tripathi AK, Desai PP, Tyagi A, Lampe JB, Srivastava Y, Donkor M, Jones HP, Dzyuba SV, Crossley E, Williams NS, Vishwanatha JK. Short peptides based on the conserved regions of MIEN1 protein exhibit anticancer activity by targeting the MIEN1 signaling pathway. J Biol Chem 2024, 300: 105680. PMID: 38272230, DOI: 10.1016/j.jbc.2024.105680.Peer-Reviewed Original ResearchPrior Influenza Infection Mitigates SARS-CoV-2 Disease in Syrian Hamsters
Di Pietro C, Haberman A, Lindenbach B, Smith P, Bruscia E, Allore H, Vander Wyk B, Tyagi A, Zeiss C. Prior Influenza Infection Mitigates SARS-CoV-2 Disease in Syrian Hamsters. Viruses 2024, 16: 246. PMID: 38400021, PMCID: PMC10891789, DOI: 10.3390/v16020246.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsTransient gene expressionSARS-CoV-2Viral replication pathwayReplication pathwayAntiviral pathwaysEndemism patternsUpregulation of innateGene expressionQuantitative RT-PCRMitigated weight lossDual-infected animalsSARS-CoV-2 viral loadSARS-CoV-2 infectionSyrian hamstersSeasonal infection ratesSARS-CoV-2 inoculationLungs of animalsIndividual virusesSARS-CoV-2 diseaseUpper respiratory tractH1N1 infectionRT-PCRBronchoalveolar lavageViral loadCytokine levelsEditorial: The molecular basis of programmed cell death and neuroinflammation in neurodegenerative diseases.
Soni C, Tyagi A, Wang X, Mathur R. Editorial: The molecular basis of programmed cell death and neuroinflammation in neurodegenerative diseases. Front Immunol 2024, 14: 1359136. PMID: 38283364, DOI: 10.3389/fimmu.2023.1359136.Commentaries, Editorials and Letters
2023
Transcriptome analysis reveals temporally regulated genetic networks during Drosophila border cell collective migration.
Burghardt E, Rakijas J, Tyagi A, Majumder P, Olson BJSC, McDonald JA. Transcriptome analysis reveals temporally regulated genetic networks during Drosophila border cell collective migration. BMC Genomics 2023, 24: 728. PMID: 38041052, DOI: 10.1186/s12864-023-09839-8.Peer-Reviewed Original ResearchTranscriptional responses of cancer cells to heat shock-inducing stimuli involve amplification of robust HSF1 binding
Dastidar S, De Kumar B, Lauckner B, Parrello D, Perley D, Vlasenok M, Tyagi A, Koney N, Abbas A, Nechaev S. Transcriptional responses of cancer cells to heat shock-inducing stimuli involve amplification of robust HSF1 binding. Nature Communications 2023, 14: 7420. PMID: 37973875, PMCID: PMC10654513, DOI: 10.1038/s41467-023-43157-7.Peer-Reviewed Original ResearchCitationsAltmetricGene loss during a transition to multicellularity.
Jiménez-Marín B, Rakijas JB, Tyagi A, Pandey A, Hanschen ER, Anderson J, Heffel MG, Platt TG, Olson BJSC. Gene loss during a transition to multicellularity. Sci Rep 2023, 13: 5268. PMID: 37002250, DOI: 10.1038/s41598-023-29742-2.Peer-Reviewed Original Research
2021
Autocrine GMCSF Signaling Contributes to Growth of HER2+ Breast Leptomeningeal CarcinomatosisGMCSF Contributes to Breast Leptomeningeal Carcinomatosis
Ansari K, Bhan A, Saotome M, Tyagi A, De Kumar B, Chen C, Takaku M, Jandial R. Autocrine GMCSF Signaling Contributes to Growth of HER2+ Breast Leptomeningeal CarcinomatosisGMCSF Contributes to Breast Leptomeningeal Carcinomatosis. Cancer Research 2021, 81: 4723-4735. PMID: 34247146, PMCID: PMC8986153, DOI: 10.1158/0008-5472.can-21-0259.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAnimalsAutocrine CommunicationBreast NeoplasmsCell Line, TumorCell ProliferationCell SurvivalDisease Models, AnimalGene ExpressionGranulocyte-Macrophage Colony-Stimulating FactorHumansMeningeal CarcinomatosisMiceOncogene ProteinsProtein Kinase InhibitorsReceptor, ErbB-2Signal TransductionXenograft Model Antitumor AssaysConceptsOligodendrocyte progenitor cellsLeptomeningeal carcinomatosisLC growthPan-Aurora kinase inhibitorKinase inhibitorsSuppression of HER2Growth of HER2Central nervous system cell typesProliferation of HER2Nervous system cell typesBreast cancer cellsPrimary HER2Targetable axisOminous complicationIntrathecal deliveryMolecular mechanismsTreatment optionsDire prognosisSpinal cordBreast cancerHER2LC developmentLeptomeningesLC/MS-MSCarcinomatosis
2016
High light intensity plays a major role in emergence of population level variation in Arabidopsis thaliana along an altitudinal gradient.
Tyagi A, Yadav A, Tripathi AM, Roy S. High light intensity plays a major role in emergence of population level variation in Arabidopsis thaliana along an altitudinal gradient. Sci Rep 2016, 6: 26160. PMID: 27211014, DOI: 10.1038/srep26160.Peer-Reviewed Original Research
2015
Genetic diversity and population structure of Arabidopsis thaliana along an altitudinal gradient.
Tyagi A, Singh S, Mishra P, Singh A, Tripathi AM, Jena SN, Roy S. Genetic diversity and population structure of Arabidopsis thaliana along an altitudinal gradient. AoB Plants 2015, 8 PMID: 26672075, DOI: 10.1093/aobpla/plv145.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
activity Medicine (Wolters Kluwer)
Journal ServiceAssociate EditorDetails06/15/2022 - Presentactivity ifferential methylation analysis of Methyl‐seq data using Nanopore Sequencing
Poster Presentation7th ANNUAL EPIGENETICS & EPIGENOMICS SYMPOSIUM. University of North DakotaDetails05/13/2024 - PresentGrand Forks, ND, United Statesactivity Frontiers
Journal ServiceAssociate EditorDetails02/02/2022 - 01/10/2024activity Sensitive identification of variants and variant phasing in newborn genetic screening using Illumina Complete Long Read (ICLR) sequencing
Poster PresentationAGBT-Precision Health 2023Details09/07/2023 - 09/09/2023San Diego, CA, United StatesAbstract/SynopsisAccurate identification and phasing of variants are paramount for the detection of pathological genetic diseases and precision medicine. Long-read sequencing is significantly more powerful than conventional short-read sequencing in terms of its ability to detect structural variants, complex variant calling, and variant phasing. SNP phasing and sequencing of difficult regions, such as repeats and structural variants of clinical significance, are critical in newborn genetic screening. We used Illumina Complete Long Read (ICLR) to sequence DNA from fresh Blood samples and compared it with data obtained from Dry Blood Spots (DBS). We also studied the effect of down-sampling on variant identification in ICLR. Sequencing libraries were prepared following the manufacturer’s protocol and sequenced on the NovaSeq 6000 platform. The sequencing data was analyzed on the DRAGEN ICLR WGS App on the BaseSpace Sequence Hub. Sequencing metrics substitution rate, median coverage, insert size, N50 value, percentage biallelic variants, and phased heterozygous SNVs were analyzed. Additionally, the number of SNPs, nonSNPs, and structural variants obtained from ICLR was compared with PacBio SMRTTM sequencing and Illumina SNP array. The results of this study show that ICLR sequencing precision reads can provide high sensitivity for newborn genetic screening
activity Sensitive identification of variants and variant phasing in newborn genetic screening using Illumina Complete Long Read (ICLR) sequencing
Poster PresentationPrecision Health-AGBT 2023Details09/07/2023 - PresentSan Diego, CA, United StatesCollaborators
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Yale Center for Genome Analysis (YCGA)
830 West campus Dr
West Haven, CT 06516
United States